APPL1 and ADIPOR2

Number of citations of the paper that reports this interaction (PubMedID 16622416)
0

Data Source:
BioGRID (two hybrid)

		APPL1	ADIPOR2
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	adiponectin receptor 2
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Actin Cytoskeleton Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Cell Projection Macropinosome Phagocytic Vesicle Extracellular Exosome Intracellular Vesicle Glutamatergic Synapse	Plasma Membrane Membrane
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Adiponectin Binding Adipokinetic Hormone Receptor Activity
	Biological Process	Protein Import Into Nucleus Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of D-glucose Import Positive Regulation Of D-glucose Import Positive Regulation Of Melanin Biosynthetic Process Positive Regulation Of Transport Maintenance Of Synapse Structure Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Lipid Metabolic Process Fatty Acid Metabolic Process Hormone-mediated Signaling Pathway Fatty Acid Oxidation Adiponectin-activated Signaling Pathway Glucose Homeostasis Vascular Wound Healing Positive Regulation Of Cold-induced Thermogenesis
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	AMPK inhibits chREBP transcriptional activation activity
Drugs
Diseases
GWAS			Adverse response to lamotrigine and phenytoin ( 22379998) Red cell distribution width ( 32888494) Urate levels in lean individuals ( 25811787)
Interacting Genes		72 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GABARAP GABARAPL1 GABARAPL2 GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RSPH1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBC UBE2O ZNF829	3 interacting genes: ADIPOQ APPL1 TMBIM6
Entrez ID		26060	79602
HPRD ID		05053	06403
Ensembl ID		ENSG00000157500	ENSG00000006831
Uniprot IDs		Q9UKG1	Q86V24
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B	5LWY 5LX9 5LXA 6KS1 6YX9 6YXD 6YXF 6YXG
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Phospholipid Binding Ubiquitin Protein Ligase Binding Autophagosome Maturation Cytosol Regulation Of Cellular Component Organization Autophagosome Membrane Signal Transduction Regulation Of D-glucose Import Endomembrane System Cell Surface Receptor Signaling Pathway Positive Regulation Of D-glucose Import Response To Starvation Macroautophagy Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of D-glucose Transmembrane Transport Positive Regulation Of D-glucose Transmembrane Transport Cellular Response To Starvation Autophagosome Regulation Of Growth Negative Regulation Of Multicellular Organismal Process Glucose Homeostasis Carbohydrate Homeostasis Intracellular Signaling Cassette Protein-containing Complex Disassembly Intracellular Signal Transduction Autophagosome Assembly Adiponectin-activated Signaling Pathway Cytoplasm Autophagy Autophagosome Organization Cellular Response To Stress Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Cellular Localization Rhythmic Process Cellular Response To Nutrient Levels Establishment Of Protein Localization Histone Deacetylase Binding Insulin Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Protein Localization To Membrane Response To Nutrient Levels Regulation Of Developmental Process	Adiponectin-activated Signaling Pathway Negative Regulation Of Phagocytosis Negative Regulation Of Transport Positive Regulation Of D-glucose Import Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Cellular Localization Negative Regulation Of Immune System Process Regulation Of D-glucose Import Negative Regulation Of Endocytosis Regulation Of D-glucose Transmembrane Transport Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Phagocytosis Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Hormone-mediated Signaling Pathway Endoribonuclease Inhibitor Activity Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Detection Of Oxidative Stress Positive Regulation Of Macropinocytosis Response To Linoleic Acid Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cholesterol Import Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Receptor Binding Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Transport Regulation Of Immune System Process Regulation Of Cholesterol Import Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of CAMP-dependent Protein Kinase Activity Macropinosome Regulation Of Endocytosis Negative Regulation Of IRE1-mediated Unfolded Protein Response Response To Sucrose Response To Disaccharide Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Pinocytosis Negative Regulation Of Macrophage Differentiation Positive Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Melanin Biosynthetic Process IRE1-mediated Unfolded Protein Response Cytokine-mediated Signaling Pathway Negative Regulation Of Granulocyte Differentiation
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