APPL1 and RHEBL1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		APPL1	RHEBL1
Gene Name		adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	Ras homolog enriched in brain like 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Endosome Membrane Vesicle Membrane NuRD Complex Early Endosome Membrane Extracellular Vesicular Exosome	Cytoplasm Endomembrane System Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Kinase B Binding	GTP Binding Metal Ion Binding
	Biological Process	Cell Cycle Signal Transduction Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Glucose Import Regulation Of Establishment Of Protein Localization To Plasma Membrane Apoptotic Signaling Pathway	Small GTPase Mediated Signal Transduction TOR Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ADIPOR1 AKT1 AKT2 APPL2 CMTM4 DCC DPYSL5 EGFR FARS2 FSHR HDAC1 HDAC2 KXD1 MAGEA9 MEOX1 MTA2 PIK3CA PLEKHF2 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 TRAF2 UBE2O	13 interactors: ACVR1 AKT1 APPL1 BMPR1B EIF4EBP1 FHL3 MTOR PRKAB2 SMAD1 SMAD2 SMAD4 TGFBR1 TXNL4A
Entrez ID		26060	121268
HPRD ID		05053	15245
Ensembl ID		ENSG00000157500	ENSG00000167550
Uniprot IDs		Q9UKG1	Q8TAI7
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O	3OES
Enriched GO Terms of Interacting Partners?		ATP-dependent Chromatin Remodeling Chromatin Remodeling Regulation Of Growth Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Tongue Development Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cellular Ketone Metabolic Process Response To UV-A Cellular Response To Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Fungiform Papilla Formation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stimulus Histone Deacetylation Protein Deacetylation Signal Transduction Fungiform Papilla Morphogenesis Regulation Of Cellular Amino Acid Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Fungiform Papilla Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Gene Expression, Epigenetic Blood Coagulation Negative Regulation Of Gene Expression, Epigenetic Peripheral Nervous System Myelin Maintenance Eyelid Development In Camera-type Eye Hemostasis Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Glycogen Biosynthetic Process Hair Follicle Placode Formation Positive Regulation Of Macromolecule Biosynthetic Process Signaling Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Growth Hair Follicle Development Response To Organic Substance Hair Cycle Process Regulation Of Signaling Tongue Morphogenesis Cell Communication Response To Stimulus Glial Cell Development Regulation Of Receptor Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process	Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Organic Substance Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Insulin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta SMAD Protein Complex Assembly Response To Organic Substance Intracellular Signal Transduction Cellular Response To Insulin Stimulus BMP Signaling Pathway Protein Phosphorylation Pattern Specification Process Positive Regulation Of Cell Differentiation Cell Fate Commitment Cellular Response To Hormone Stimulus Response To Insulin Regulation Of Cell Differentiation Activin Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Gamete Generation Cellular Response To Peptide Mesoderm Development Urogenital System Development Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Sexual Reproduction Peptidyl-threonine Phosphorylation Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Reproductive Process Gastrulation Response To Organonitrogen Compound Regulation Of Epithelial To Mesenchymal Transition Cell Cycle Multicellular Organism Reproduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Peptide Hormone Posttranscriptional Regulation Of Gene Expression Signal Transduction Cardiovascular System Development Mesenchyme Development Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Organonitrogen Compound Organ Development
Tagcloud ?		characterised colocalisation colocalises compartments eea1 employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst	aspartate binds cad carbamoyl consist de dihydroorotase effector farnesyltransferase gtp gtpases immunostaining knocking lysosomes mislocalized multifunctional novo nucleotides phosphate pronounced pyrimidine rheb2 superfamily synthetase transcarbamoylase tsc2 utp
Tagcloud (Difference) ?		characterised colocalisation colocalises compartments eea1 employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst	aspartate binds cad carbamoyl consist de dihydroorotase effector farnesyltransferase gtp gtpases immunostaining knocking lysosomes mislocalized multifunctional novo nucleotides phosphate pronounced pyrimidine rheb2 superfamily synthetase transcarbamoylase tsc2 utp
Tagcloud (Intersection) ?