PLEKHF2 and S100A1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PLEKHF2	S100A1
Gene Name		pleckstrin homology domain containing, family F (with FYVE domain) member 2	S100 calcium binding protein A1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane	Nucleus Sarcoplasmic Reticulum Z Disc M Band Neuron Projection Protein Complex
	Molecular Function	Protein Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding ATPase Binding
	Biological Process	Protein Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Positive Regulation Of Voltage-gated Calcium Channel Activity
Pathways
Drugs			Olopatadine
Diseases
GWAS		Radiation response ( 20923822)
Protein-Protein Interactions		52 interactors: ACY3 AIMP2 APP APPL1 BEND7 BLOC1S6 BSCL2 CCDC85B CEP44 CHIC2 DTX2 DUT FBXO28 FHL3 FRMD8 GFER GLUL GNMT GPBP1 GPBP1L1 HSPB7 L3MBTL3 LDOC1 MAX MBIP MEAF6 NONO NPM2 PRKAR1A PRPSAP1 RABAC1 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SDPR SEPT2 SEPT6 SETBP1 SFN SPEF1 TNFAIP8 TRAF6 TRAPPC3 TSC22D3 TXNL4B UBE2Z ZNF250 ZNF263 ZNF398	24 interactors: ACTA1 AGER ANXA6 ATP2A2 CACYBP CAPZA1 DES FKBP4 GFAP GJA1 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM RYR1 S100A2 S100A4 S100B S100P SYN1
Entrez ID		79666	6271
HPRD ID		15147	01489
Ensembl ID		ENSG00000175895	ENSG00000160678
Uniprot IDs		Q9H8W4	P23297
PDB IDs			2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Cellular Metabolic Process	Muscle System Process Response To Abiotic Stimulus Regulation Of Cardiac Muscle Cell Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Protein Complex Assembly Sarcoplasmic Reticulum Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Muscle Contraction Relaxation Of Cardiac Muscle Regulation Of Striated Muscle Contraction Glycogen Catabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Polysaccharide Catabolic Process Calcium Ion Transport Relaxation Of Muscle Striated Muscle Tissue Development Negative Regulation Of Heart Contraction Skeletal Muscle Fiber Development Response To Hormone Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Metal Ion Muscle Tissue Development Cellular Component Assembly Myotube Cell Development Regulation Of Cellular Localization Cellular Carbohydrate Catabolic Process Regulation Of The Force Of Heart Contraction Actin-myosin Filament Sliding Muscle Filament Sliding Response To Wounding Regulation Of Ion Homeostasis Regulation Of Actin Filament-based Process Cellular Metal Ion Homeostasis Cellular Response To Alkaloid Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Astrocyte Differentiation Cytosolic Calcium Ion Homeostasis Cellular Cation Homeostasis Actin-mediated Cell Contraction Cellular Ion Homeostasis Response To Peptide Hormone Cardiac Conduction Tissue Development Negative Regulation Of Striated Muscle Tissue Development Steroid Hormone Receptor Complex Assembly Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Positive Regulation Of Schwann Cell Proliferation
Tagcloud ?		abnormally attempt cargo colocalized concert depleted dextran discover eea1 effectors egf endosomal endosome endosomes enlarged facilitating fyve interactor microdomains mtmr4 orchestrates phafin2 proteome ptdins3p px recruiting screen termination tethering	ablation ad ascertain astrocytosis burden collectively demonstration detrimental elucidated gfap gsk3beta iba1 identifies indirectly microgliosis modulates neuroinflammation normalizing pathobiology pc12 plaque po4 psapp ryanodine ryr sensor twelve undetectable uses
Tagcloud (Difference) ?		abnormally attempt cargo colocalized concert depleted dextran discover eea1 effectors egf endosomal endosome endosomes enlarged facilitating fyve interactor microdomains mtmr4 orchestrates phafin2 proteome ptdins3p px recruiting screen termination tethering	ablation ad ascertain astrocytosis burden collectively demonstration detrimental elucidated gfap gsk3beta iba1 identifies indirectly microgliosis modulates neuroinflammation normalizing pathobiology pc12 plaque po4 psapp ryanodine ryr sensor twelve undetectable uses
Tagcloud (Intersection) ?