APPL1 and GPC3

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		APPL1	GPC3
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	glypican 3
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Actin Cytoskeleton Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Cell Projection Macropinosome Phagocytic Vesicle Extracellular Exosome Intracellular Vesicle Glutamatergic Synapse	Lysosome Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Membrane Lysosomal Lumen Side Of Membrane
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding Peptidase Inhibitor Activity Peptidyl-dipeptidase Inhibitor Activity
	Biological Process	Protein Import Into Nucleus Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of D-glucose Import Positive Regulation Of D-glucose Import Positive Regulation Of Melanin Biosynthetic Process Positive Regulation Of Transport Maintenance Of Synapse Structure Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Smoothened Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Bacterium Anatomical Structure Morphogenesis Animal Organ Morphogenesis Anterior/posterior Axis Specification Regulation Of Signal Transduction Body Morphogenesis Cell Migration Bone Mineralization Osteoclast Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Embryonic Hindlimb Morphogenesis Regulation Of Growth Cell Migration Involved In Gastrulation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Growth Positive Regulation Of D-glucose Import Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesonephric Duct Morphogenesis Cell Proliferation Involved In Metanephros Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS			Educational attainment (years of education) ( 30038396) Relative hand skill ( 24068947)
Interacting Genes		72 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GABARAP GABARAPL1 GABARAPL2 GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RSPH1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBC UBE2O ZNF829	6 interacting genes: APPL1 FGF2 IGF2 PTPRS WNT3A WNT7B
Entrez ID		26060	2719
HPRD ID		05053	02074
Ensembl ID		ENSG00000157500	ENSG00000147257
Uniprot IDs		Q9UKG1	B4DTD8 I6QTG3 P51654 Q53H15
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B	7ZA1 7ZAW
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Phospholipid Binding Ubiquitin Protein Ligase Binding Autophagosome Maturation Cytosol Regulation Of Cellular Component Organization Autophagosome Membrane Signal Transduction Regulation Of D-glucose Import Endomembrane System Cell Surface Receptor Signaling Pathway Positive Regulation Of D-glucose Import Response To Starvation Macroautophagy Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of D-glucose Transmembrane Transport Positive Regulation Of D-glucose Transmembrane Transport Cellular Response To Starvation Autophagosome Regulation Of Growth Negative Regulation Of Multicellular Organismal Process Glucose Homeostasis Carbohydrate Homeostasis Intracellular Signaling Cassette Protein-containing Complex Disassembly Intracellular Signal Transduction Autophagosome Assembly Adiponectin-activated Signaling Pathway Cytoplasm Autophagy Autophagosome Organization Cellular Response To Stress Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Cellular Localization Rhythmic Process Cellular Response To Nutrient Levels Establishment Of Protein Localization Histone Deacetylase Binding Insulin Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Protein Localization To Membrane Response To Nutrient Levels Regulation Of Developmental Process	Positive Regulation Of Cell Fate Specification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Embryonic Placenta Morphogenesis Regulation Of Developmental Growth Canonical Wnt Signaling Pathway Embryonic Morphogenesis Osteoblast Differentiation Positive Regulation Of Cell Fate Commitment Receptor Ligand Activity Regulation Of Growth Positive Regulation Of Developmental Growth Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Collateral Sprouting Regulation Of Cell Fate Specification Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Regulation Of Skeletal Muscle Tissue Development Regulation Of Cell Differentiation Cytokine Activity Negative Regulation Of Axon Extension Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Growth Chordate Embryonic Development In Utero Embryonic Development Synapse Organization Frizzled Binding Regulation Of Cell Communication Regulation Of Signaling Wnt Signaling Pathway Regulation Of Fibroblast Migration Regulation Of Striated Muscle Tissue Development Cell Development Positive Chemotaxis Regulation Of Muscle Organ Development Regulation Of Cell Fate Commitment Cell Surface Receptor Signaling Pathway Positive Regulation Of Organ Growth Non-canonical Wnt Signaling Pathway Negative Regulation Of Axonogenesis Positive Regulation Of Neural Precursor Cell Proliferation Neuron Differentiation Regulation Of Neurogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Retinoic Acid Signal Transduction Tissue Morphogenesis Hippocampus Development
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