PLEKHF2 and BLOC1S6

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		PLEKHF2	BLOC1S6
Gene Name		pleckstrin homology domain containing, family F (with FYVE domain) member 2	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane	Nucleoplasm Cytoplasm Endosome Cytosol Extrinsic Component Of Membrane Transport Vesicle BLOC-1 Complex SNARE Complex
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding Syntaxin Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding
	Biological Process	Protein Transport	Post-Golgi Vesicle-mediated Transport Blood Coagulation Anterograde Axon Cargo Transport Synaptic Vesicle Docking Melanocyte Differentiation Neuron Projection Development Melanosome Transport Melanosome Organization Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Endosome To Melanosome Transport Anterograde Synaptic Vesicle Transport Positive Regulation Of Pigment Cell Differentiation Membrane Organization Membrane Fusion
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Radiation response ( 20923822)
Protein-Protein Interactions		52 interactors: ACY3 AIMP2 APP APPL1 BEND7 BLOC1S6 BSCL2 CCDC85B CEP44 CHIC2 DTX2 DUT FBXO28 FHL3 FRMD8 GFER GLUL GNMT GPBP1 GPBP1L1 HSPB7 L3MBTL3 LDOC1 MAX MBIP MEAF6 NONO NPM2 PRKAR1A PRPSAP1 RABAC1 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SDPR SEPT2 SEPT6 SETBP1 SFN SPEF1 TNFAIP8 TRAF6 TRAPPC3 TSC22D3 TXNL4B UBE2Z ZNF250 ZNF263 ZNF398	38 interactors: ABI2 AGGF1 ANK1 APP BLOC1S1 BLOC1S2 BLOC1S4 CCDC136 CCDC22 CCDC53 CCHCR1 CDK5R1 CORO6 DCTN2 DTNBP1 EPS8 EXOC8 HAUS1 IFT20 KRT13 LURAP1 MED21 NDC80 NDN NUP62 OLFM2 PLEKHA5 PLEKHF2 RABGEF1 SKA1 SLC4A1 SMN2 SNAPIN STX11 STX12 SYCE3 TPM3 WDYHV1
Entrez ID		79666	26258
HPRD ID		15147	16055
Ensembl ID		ENSG00000175895	ENSG00000104164
Uniprot IDs		Q9H8W4	B3KY40 Q9UL45
PDB IDs
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Cellular Metabolic Process	Anterograde Synaptic Vesicle Transport Establishment Of Localization In Cell Axon Cargo Transport Melanosome Organization Pigment Granule Organization Organelle Organization Cellular Pigmentation Anterograde Axon Cargo Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Cellular Localization Organelle Localization Synaptic Vesicle Transport Movement Of Cell Or Subcellular Component Establishment Of Vesicle Localization Intracellular Transport Pigmentation Vesicle Organization Establishment Of Organelle Localization Vesicle Localization Membrane Organization Neuron Development Microtubule-based Process Neuron Projection Development Platelet Dense Granule Organization Microtubule-based Movement Cytoskeleton Organization Neuron Differentiation Cell Projection Organization Vesicle-mediated Transport Protein Localization Protein Transport Establishment Of Protein Localization Cell Development Post-Golgi Vesicle-mediated Transport Generation Of Neurons Cellular Protein Localization Neurogenesis Neuron Recognition Secretory Granule Organization Transport Endomembrane System Organization Golgi Vesicle Transport Vesicle Fusion Nervous System Development Mitotic Nuclear Division Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Exocytosis Organelle Fusion
Tagcloud ?		abnormally attempt cargo colocalized concert depleted dextran discover eea1 effectors egf endosomal endosome endosomes enlarged facilitating fyve interactor microdomains mtmr4 orchestrates phafin2 proteome ptdins3p px recruiting screen termination tethering
Tagcloud (Difference) ?		abnormally attempt cargo colocalized concert depleted dextran discover eea1 effectors egf endosomal endosome endosomes enlarged facilitating fyve interactor microdomains mtmr4 orchestrates phafin2 proteome ptdins3p px recruiting screen termination tethering
Tagcloud (Intersection) ?