APPL1 and FSHR

Number of citations of the paper that reports this interaction (PubMedID 15070827)
0

Data Source:
HPRD (two hybrid, in vivo)

		APPL1	FSHR
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	follicle stimulating hormone receptor
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Actin Cytoskeleton Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Cell Projection Macropinosome Phagocytic Vesicle Extracellular Exosome Intracellular Vesicle Glutamatergic Synapse	Endosome Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	G Protein-coupled Receptor Activity Follicle-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Peptide Hormone Binding Signaling Receptor Activity
	Biological Process	Protein Import Into Nucleus Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of D-glucose Import Positive Regulation Of D-glucose Import Positive Regulation Of Melanin Biosynthetic Process Positive Regulation Of Transport Maintenance Of Synapse Structure Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Ovarian Follicle Development Primary Ovarian Follicle Growth Regulation Of Systemic Arterial Blood Pressure Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Spermatid Development Female Gamete Generation Locomotory Behavior Gonad Development Male Gonad Development Female Gonad Development Response To Hormone Hormone-mediated Signaling Pathway Intracellular Water Homeostasis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase A Signaling Ovulation Cycle Process Neuron Projection Development Regulation Of Hormone Metabolic Process Regulation Of Chromosome Organization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Sperm DNA Condensation Follicle-stimulating Hormone Signaling Pathway Regulation Of MAPK Cascade Transcytosis Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Sertoli Cell Development Sertoli Cell Proliferation Uterus Development Regulation Of Acetylcholine Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Follicle-stimulating Hormone Stimulus Basement Membrane Organization
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	Hormone ligand-binding receptors G alpha (s) signalling events
Drugs			Menotropins Follitropin Urofollitropin Choriogonadotropin alfa Suramin Corifollitropin alfa
Diseases			Ovarian hyperstimulation syndrome (OHSS) Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) ( 23648065) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Chronotype ( 30696823) Daytime nap ( 33568662) Depressive symptoms (SSRI exposure interaction) ( 25649181) Erectile dysfunction and prostate cancer treatment ( 20932654) HDL cholesterol levels in HIV infection ( 33109212) Laterality in neovascular age-related macular degeneration ( 28775256) Lean body mass ( 28552196) Low density lipoprotein cholesterol levels ( 30498476) Lung cancer in ever smokers ( 28604730) Metabolite levels ( 23823483) Morning person ( 30696823) Plasma anti-thyroglobulin levels ( 29678681) Polycystic ovary syndrome ( 22885925 21151128) Radiation response ( 20923822) Recurrent major depressive disorder ( 34099189) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		72 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GABARAP GABARAPL1 GABARAPL2 GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RSPH1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBC UBE2O ZNF829	21 interacting genes: AKT2 APPL1 ARR3 CANX CBX5 CGA FSHB GRK2 GRK4 GRK6 MT-RNR2 RPS27A S100A10 SNCA TOP1 TUG1 UBA52 UBB UBC YWHAQ ZBTB16
Entrez ID		26060	2492
HPRD ID		05053	00639
Ensembl ID		ENSG00000157500	ENSG00000170820
Uniprot IDs		Q9UKG1	B4DXB5 P23945
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B	1XWD 4AY9 4MQW 8I2G 8I2H
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Phospholipid Binding Ubiquitin Protein Ligase Binding Autophagosome Maturation Cytosol Regulation Of Cellular Component Organization Autophagosome Membrane Signal Transduction Regulation Of D-glucose Import Endomembrane System Cell Surface Receptor Signaling Pathway Positive Regulation Of D-glucose Import Response To Starvation Macroautophagy Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of D-glucose Transmembrane Transport Positive Regulation Of D-glucose Transmembrane Transport Cellular Response To Starvation Autophagosome Regulation Of Growth Negative Regulation Of Multicellular Organismal Process Glucose Homeostasis Carbohydrate Homeostasis Intracellular Signaling Cassette Protein-containing Complex Disassembly Intracellular Signal Transduction Autophagosome Assembly Adiponectin-activated Signaling Pathway Cytoplasm Autophagy Autophagosome Organization Cellular Response To Stress Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Cellular Localization Rhythmic Process Cellular Response To Nutrient Levels Establishment Of Protein Localization Histone Deacetylase Binding Insulin Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Protein Localization To Membrane Response To Nutrient Levels Regulation Of Developmental Process	Protein Tag Activity G Protein-coupled Receptor Kinase Activity Receptor Internalization Receptor-mediated Endocytosis Follicle-stimulating Hormone Activity Follicle-stimulating Hormone Complex Endocytic Vesicle Membrane Follicle-stimulating Hormone Signaling Pathway Mitochondrial Outer Membrane Beta-adrenergic Receptor Kinase Activity Endosome Membrane Regulation Of G Protein-coupled Receptor Signaling Pathway Vesicle Protein Serine/threonine Kinase Activity Protein Domain Specific Binding Endocytosis Ubiquitin Protein Ligase Binding Negative Regulation Of Relaxation Of Smooth Muscle Import Into Cell Regulation Of Catecholamine Secretion Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Lipid Metabolic Process Cell Cortex Cellular Response To High Light Intensity Positive Regulation Of Lipid Metabolic Process Positive Regulation Of D-glucose Import Positive Regulation Of D-glucose Transmembrane Transport Phosphoprotein Binding Synaptic Vesicle Endocytosis Presynaptic Endocytosis Proteolysis Involved In Protein Catabolic Process Ovulation Cycle Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Extracellular Space Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Beta-tubulin Binding Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ribosome Negative Regulation Of Transport Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Edg-2 Lysophosphatidic Acid Receptor Binding Protein Modification Process Response To High Light Intensity
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