APPL1 and FARS2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		APPL1	FARS2
Gene Name		adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	phenylalanyl-tRNA synthetase 2, mitochondrial
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Endosome Membrane Vesicle Membrane NuRD Complex Early Endosome Membrane Extracellular Vesicular Exosome	Mitochondrial Matrix
	Molecular Function	Protein Binding Identical Protein Binding Protein Kinase B Binding	TRNA Binding Magnesium Ion Binding Phenylalanine-tRNA Ligase Activity ATP Binding
	Biological Process	Cell Cycle Signal Transduction Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Glucose Import Regulation Of Establishment Of Protein Localization To Plasma Membrane Apoptotic Signaling Pathway	TRNA Aminoacylation For Protein Translation Phenylalanyl-tRNA Aminoacylation TRNA Processing Gene Expression
Pathways		Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway	tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs			L-Phenylalanine
Diseases
GWAS			Obesity (early onset extreme) ( 23563609)
Protein-Protein Interactions		25 interactors: ADIPOR1 AKT1 AKT2 APPL2 CMTM4 DCC DPYSL5 EGFR FARS2 FSHR HDAC1 HDAC2 KXD1 MAGEA9 MEOX1 MTA2 PIK3CA PLEKHF2 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 TRAF2 UBE2O	23 interactors: ADAMTSL4 AGTRAP APPL1 CALCOCO2 CMTM5 HMBOX1 IKZF3 KRT13 KRT31 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-9 MID2 MKRN3 NOTCH2NL RCBTB2 STX11 TADA2A TFCP2 TRIM27 TRIM54
Entrez ID		26060	10667
HPRD ID		05053	09946
Ensembl ID		ENSG00000157500	ENSG00000145982
Uniprot IDs		Q9UKG1	O95363
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O	3CMQ 3HFV 3TEG 3TUP
Enriched GO Terms of Interacting Partners?		ATP-dependent Chromatin Remodeling Chromatin Remodeling Regulation Of Growth Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Tongue Development Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cellular Ketone Metabolic Process Response To UV-A Cellular Response To Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Fungiform Papilla Formation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stimulus Histone Deacetylation Protein Deacetylation Signal Transduction Fungiform Papilla Morphogenesis Regulation Of Cellular Amino Acid Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Fungiform Papilla Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Gene Expression, Epigenetic Blood Coagulation Negative Regulation Of Gene Expression, Epigenetic Peripheral Nervous System Myelin Maintenance Eyelid Development In Camera-type Eye Hemostasis Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Glycogen Biosynthetic Process Hair Follicle Placode Formation Positive Regulation Of Macromolecule Biosynthetic Process Signaling Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Growth Hair Follicle Development Response To Organic Substance Hair Cycle Process Regulation Of Signaling Tongue Morphogenesis Cell Communication Response To Stimulus Glial Cell Development Regulation Of Receptor Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process	Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell
Tagcloud ?		characterised colocalisation colocalises compartments eea1 employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst
Tagcloud (Difference) ?		characterised colocalisation colocalises compartments eea1 employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst
Tagcloud (Intersection) ?