PLEKHF2 and S100A13

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PLEKHF2	S100A13
Description		pleckstrin homology and FYVE domain containing 2	S100 calcium binding protein A13
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Endoplasmic Reticulum Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Early Endosome Membrane	Extracellular Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding	Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Lipid Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity Metal Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Endosome Organization Endosome To Lysosome Transport Protein Transport	Positive Regulation Of Cytokine Production Protein Transport Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Mast Cell Degranulation
Pathways
Drugs			Olopatadine Amlexanox Calcium chloride Calcium Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Radiation response ( 20923822)	Plateletcrit ( 32888494)
Interacting Genes		168 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HSPB7 INO80 KCNAB3 KCNJ5-AS1 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581	10 interacting genes: FBXO7 FGF1 IGBP1 IL1A IRF9 PHYHIP PLEKHF2 S100A14 SYT1 TNF
Entrez ID		79666	6284
HPRD ID		15147	03586
Ensembl ID		ENSG00000175895	ENSG00000189171
Uniprot IDs		Q9H8W4	Q99584
PDB IDs			1YUR 1YUS 1YUT 1YUU 2EGD 2H2K 2K8M 2KI4 2KI6 2KOT 2L5X 2LE9
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Endoplasmic Reticulum Tubular Network Formation	Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Steroid Biosynthetic Process Regulation Of MAPK Cascade Branch Elongation Involved In Ureteric Bud Branching Cellular Response To Heat Positive Regulation Of Steroid Metabolic Process Immune System Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitotic Nuclear Division Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of MAP Kinase Activity Response To Lipopolysaccharide Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Anatomical Structure Morphogenesis Regulation Of Steroid Biosynthetic Process Response To Heat Regulation Of Morphogenesis Of An Epithelium Regulation Of Animal Organ Morphogenesis Response To Molecule Of Bacterial Origin Calcium-dependent Protein Binding Syntaxin-3 Binding Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Amine Transport Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Fractalkine Production Positive Regulation Of Blood Microparticle Formation Response To Gold Nanoparticle Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Cell Division Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Metabolic Process Fever Generation
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