PLEKHF2 and GNMT

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLEKHF2	GNMT
Gene Name		pleckstrin homology domain containing, family F (with FYVE domain) member 2	glycine N-methyltransferase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane	Cytoplasm
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding Folic Acid Binding Glycine Binding Glycine N-methyltransferase Activity
	Biological Process	Protein Transport	Glycogen Metabolic Process Regulation Of Gluconeogenesis Cellular Protein Modification Process Methionine Metabolic Process One-carbon Metabolic Process Methylation S-adenosylmethionine Metabolic Process Protein Homotetramerization
Pathways
Drugs			S-Adenosylmethionine Glycine S-Adenosyl-L-Homocysteine Citric Acid
Diseases
GWAS		Radiation response ( 20923822)
Protein-Protein Interactions		52 interactors: ACY3 AIMP2 APP APPL1 BEND7 BLOC1S6 BSCL2 CCDC85B CEP44 CHIC2 DTX2 DUT FBXO28 FHL3 FRMD8 GFER GLUL GNMT GPBP1 GPBP1L1 HSPB7 L3MBTL3 LDOC1 MAX MBIP MEAF6 NONO NPM2 PRKAR1A PRPSAP1 RABAC1 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SDPR SEPT2 SEPT6 SETBP1 SFN SPEF1 TNFAIP8 TRAF6 TRAPPC3 TSC22D3 TXNL4B UBE2Z ZNF250 ZNF263 ZNF398	18 interactors: ADAMTSL4 ARR3 ARRB1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NL NUDT18 PLEKHF2 POT1 PRKACA RPSA SDCBP TERF1 TERF2 TERF2IP TINF2 WDYHV1
Entrez ID		79666	27232
HPRD ID		15147	05970
Ensembl ID		ENSG00000175895	ENSG00000124713
Uniprot IDs		Q9H8W4	Q14749
PDB IDs			1R74 2AZT
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Cellular Metabolic Process	Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomerase Telomere Maintenance RNA-dependent DNA Replication Telomere Capping Negative Regulation Of Chromosome Organization Regulation Of Chromosome Organization Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Replication Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Localization To Chromosome Regulation Of Organelle Organization Telomeric Loop Formation Age-dependent Telomere Shortening Regulation Of DNA Replication Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Telomere Assembly Regulation Of Cellular Component Organization Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity DNA Replication Chromosome Organization Regulation Of Telomerase Activity Organelle Organization Negative Regulation Of DNA Biosynthetic Process Cellular Component Assembly Positive Regulation Of DNA Metabolic Process Protein Localization Homeostatic Process Negative Regulation Of Cellular Metabolic Process Protein Localization To Organelle Regulation Of DNA Biosynthetic Process DNA Metabolic Process Negative Regulation Of Protein ADP-ribosylation DGDP Catabolic Process DADP Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis GDP Catabolic Process Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		abnormally attempt cargo colocalized concert depleted dextran discover eea1 effectors egf endosomal endosome endosomes enlarged facilitating fyve interactor microdomains mtmr4 orchestrates phafin2 proteome ptdins3p px recruiting screen termination tethering	according classified dehydrogenase dfs differed glycine goal ihc luminal metabolism methyltransferase namely negativity null oxidase pipecolic pipox progesterone sarcosine sardh shorter showing stratified stromal subtype tnbc tumoral univariate varied
Tagcloud (Difference) ?		abnormally attempt cargo colocalized concert depleted dextran discover eea1 effectors egf endosomal endosome endosomes enlarged facilitating fyve interactor microdomains mtmr4 orchestrates phafin2 proteome ptdins3p px recruiting screen termination tethering	according classified dehydrogenase dfs differed glycine goal ihc luminal metabolism methyltransferase namely negativity null oxidase pipecolic pipox progesterone sarcosine sardh shorter showing stratified stromal subtype tnbc tumoral univariate varied
Tagcloud (Intersection) ?