APPL1 and DCC

Number of citations of the paper that reports this interaction (PMID 12011067)
28

Data Source:
HPRD (two hybrid, in vivo)

		APPL1	DCC
Gene Name		adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	DCC netrin 1 receptor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Endosome Membrane Vesicle Membrane NuRD Complex Early Endosome Membrane Extracellular Vesicular Exosome	Cytosol Plasma Membrane Integral Component Of Membrane Axon Growth Cone Membrane Membrane Raft
	Molecular Function	Protein Binding Identical Protein Binding Protein Kinase B Binding	Transcription Coactivator Activity Transmembrane Signaling Receptor Activity Netrin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Cell Cycle Signal Transduction Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Glucose Import Regulation Of Establishment Of Protein Localization To Plasma Membrane Apoptotic Signaling Pathway	Neuron Migration Response To Amphetamine Apoptotic Process Axonogenesis Axon Guidance Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Spinal Cord Ventral Commissure Morphogenesis Dorsal/ventral Axon Guidance Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Collateral Sprouting Positive Regulation Of ERK1 And ERK2 Cascade Apoptotic Signaling Pathway Regulation Of Neuron Death Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Dendrite Development
Pathways		Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway	DSCAM interactions Axon guidance Role of second messengers in netrin-1 signaling DCC mediated attractive signaling Programmed Cell Death Netrin mediated repulsion signals Netrin-1 signaling Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs
Diseases
GWAS			Alcoholism (alcohol use disorder factor score) ( 21529783) Body mass index (interaction) ( 23192594) Gallbladder cancer ( 22318345) Obesity-related traits ( 23251661)
Protein-Protein Interactions		25 interactors: ADIPOR1 AKT1 AKT2 APPL2 CMTM4 DCC DPYSL5 EGFR FARS2 FSHR HDAC1 HDAC2 KXD1 MAGEA9 MEOX1 MTA2 PIK3CA PLEKHF2 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 TRAF2 UBE2O	16 interactors: ADORA2B APPL1 AR BARD1 CASP3 CASP9 MAPK3 MAZ NCK1 NTN1 PITPNA PTK2 PTK2B RPL5 SIAH1 SIAH2
Entrez ID		26060	1630
HPRD ID		05053	00391
Ensembl ID		ENSG00000157500
Uniprot IDs		Q9UKG1	P43146 Q49AK4
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O	2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4
Enriched GO Terms of Interacting Partners?		ATP-dependent Chromatin Remodeling Chromatin Remodeling Regulation Of Growth Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Tongue Development Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cellular Ketone Metabolic Process Response To UV-A Cellular Response To Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Fungiform Papilla Formation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stimulus Histone Deacetylation Protein Deacetylation Signal Transduction Fungiform Papilla Morphogenesis Regulation Of Cellular Amino Acid Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Fungiform Papilla Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Gene Expression, Epigenetic Blood Coagulation Negative Regulation Of Gene Expression, Epigenetic Peripheral Nervous System Myelin Maintenance Eyelid Development In Camera-type Eye Hemostasis Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Glycogen Biosynthetic Process Hair Follicle Placode Formation Positive Regulation Of Macromolecule Biosynthetic Process Signaling Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Growth Hair Follicle Development Response To Organic Substance Hair Cycle Process Regulation Of Signaling Tongue Morphogenesis Cell Communication Response To Stimulus Glial Cell Development Regulation Of Receptor Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process	Cell Morphogenesis Involved In Differentiation Apoptotic Process Axon Guidance Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Cell Morphogenesis Regulation Of Cell Death Neuron Differentiation Signal Complex Assembly Neuron Projection Development Axonogenesis Cell Development Response To External Stimulus Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Projection Organization Neurogenesis Positive Regulation Of Protein Metabolic Process Locomotion Vascular Endothelial Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Peptidyl-tyrosine Autophosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Regulation Of Protein Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process ERBB Signaling Pathway Nervous System Development Regulation Of Protein Kinase Activity Glial Cell Apoptotic Process Regulation Of Kinase Activity System Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process
Tagcloud ?		characterised colocalisation colocalises compartments eea1 employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		characterised colocalisation colocalises compartments eea1 employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?