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MADD
Description
MAP kinase activating death domain
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Axon
Cell Projection
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Death Receptor Binding
Protein Binding
Protein Kinase Activator Activity
Biological Process
Apoptotic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Rab Protein Signal Transduction
Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Regulation Of Cell Cycle
Execution Phase Of Apoptosis
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
C-reactive protein levels (
30388399
)
Chronic kidney disease (
26831199
)
Chronotype (
30696823
)
Corneal astigmatism (
29422769
)
Fasting blood glucose (
20081858
22581228
25631608
)
Fasting blood glucose (BMI interaction) (
22581228
)
Fasting blood proinsulin levels (
23263489
)
Fasting glucose (
34059833
)
General factor of neuroticism (
30867560
)
Glaucoma (primary open-angle) (
29891935
)
Glycemic traits (pleiotropy) (
31021400
)
HDL cholesterol (
25961943
19060911
)
HDL cholesterol levels x long total sleep time interaction (2df test) (
31719535
)
HDL cholesterol levels x short total sleep time interaction (2df test) (
31719535
)
Insulin-related traits (multivariate analysis) (
32002517
)
Loneliness (
29970889
)
Loneliness (MTAG) (
29970889
)
Monocyte percentage of white cells (
32888494
)
Neuroticism (
29255261
)
Proinsulin levels (
21873549
)
Refractive error (
32231278
)
Interacting Genes
12 interacting genes:
NPDC1
PCNT
PIDD1
POT1
PTPRN
RB1CC1
RBM11
TNFRSF10A
TNFRSF10B
TNFRSF1A
VPS13D
YWHAZ
Entrez ID
8567
HPRD ID
04664
Ensembl ID
ENSG00000110514
Uniprot IDs
A0A0A0MRB5
A0A0U1RR25
A0A9L9PXF1
A0A9L9PXN0
A0A9L9PXZ0
A0A9L9PXZ3
A0A9L9PY18
A0A9L9PY22
Q8WXG6
PDB IDs
Enriched GO Terms of Interacting Partners
?
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Death Receptor Activity
TRAIL Binding
Cellular Response To Mechanical Stimulus
TRAIL-activated Apoptotic Signaling Pathway
Activation Of NF-kappaB-inducing Kinase Activity
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Process
Cell Death
Programmed Cell Death
Response To Mechanical Stimulus
Activation Of Protein Kinase Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
TRAIL Receptor Activity
Ribophagy
Positive Regulation Of DNA Strand Elongation
Positive Regulation Of Telomeric D-loop Disassembly
G-rich Single-stranded DNA Binding
Signaling Receptor Activity
Regulation Of Canonical NF-kappaB Signal Transduction
Synaptic Target Recognition
Positive Regulation Of Telomeric Loop Disassembly
Dense Core Granule Maturation
8-hydroxy-2'-deoxyguanosine DNA Binding
Telomeric G-quadruplex DNA Binding
Endopeptidase Complex
Response To Stress
Secretory Granule Maturation
Positive Regulation Of Type B Pancreatic Cell Proliferation
Negative Regulation Of Extracellular Matrix Constituent Secretion
Pulmonary Valve Development
Tumor Necrosis Factor Receptor Superfamily Complex
Telomeric D-loop Binding
Telomere Assembly
Protein Retention In Golgi Apparatus
Cellular Response To Stress
Golgi Reassembly
Single-stranded Telomeric DNA Binding
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Metabolic Process
Aortic Valve Development
Semi-lunar Valve Development
Phosphoserine Residue Binding
Positive Regulation Of Kinase Activity
Shelterin Complex
Organelle Organization
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