MADD

Name	MAP kinase activating death domain
Structure	No pdb structure
Interactors	12 interactors: NPDC1 PCNT PIDD1 POT1 PTPRN RB1CC1 RBM11 TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Axon Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Death Receptor Binding Protein Binding Protein Kinase Activator Activity
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Rab Protein Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway
GWAS	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Autism spectrum disorder or schizophrenia ( 28540026 ) C-reactive protein levels ( 30388399 ) Chronic kidney disease ( 26831199 ) Chronotype ( 30696823 ) Corneal astigmatism ( 29422769 ) Fasting blood glucose ( 20081858 22581228 25631608 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting blood proinsulin levels ( 23263489 ) Fasting glucose ( 34059833 ) General factor of neuroticism ( 30867560 ) Glaucoma (primary open-angle) ( 29891935 ) Glycemic traits (pleiotropy) ( 31021400 ) HDL cholesterol ( 25961943 19060911 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Insulin-related traits (multivariate analysis) ( 32002517 ) Loneliness ( 29970889 ) Loneliness (MTAG) ( 29970889 ) Monocyte percentage of white cells ( 32888494 ) Neuroticism ( 29255261 ) Proinsulin levels ( 21873549 ) Refractive error ( 32231278 )
Entrez ID	8567
HPRD ID	04664
Ensembl ID	ENSG00000110514
Uniprot IDs	A0A0A0MRB5 A0A0U1RR25 A0A9L9PXF1 A0A9L9PXN0 A0A9L9PXZ0 A0A9L9PXZ3 A0A9L9PY18 A0A9L9PY22 Q8WXG6
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Death Receptor Activity TRAIL Binding Cellular Response To Mechanical Stimulus TRAIL-activated Apoptotic Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Cell Death Programmed Cell Death Response To Mechanical Stimulus Activation Of Protein Kinase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death TRAIL Receptor Activity Ribophagy Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Signaling Receptor Activity Regulation Of Canonical NF-kappaB Signal Transduction Synaptic Target Recognition Positive Regulation Of Telomeric Loop Disassembly Dense Core Granule Maturation 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Endopeptidase Complex Response To Stress Secretory Granule Maturation Positive Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Telomeric D-loop Binding Telomere Assembly Protein Retention In Golgi Apparatus Cellular Response To Stress Golgi Reassembly Single-stranded Telomeric DNA Binding Positive Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Aortic Valve Development Semi-lunar Valve Development Phosphoserine Residue Binding Positive Regulation Of Kinase Activity Shelterin Complex Organelle Organization