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MADD
Gene Name
MAP-kinase activating death domain
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Membrane
Molecular Function
Death Receptor Binding
Protein Binding
Rab Guanyl-nucleotide Exchange Factor Activity
Protein Kinase Activator Activity
Biological Process
Activation Of MAPK Activity
Cell Surface Receptor Signaling Pathway
Regulation Of Rab Protein Signal Transduction
Positive Regulation Of Rab GTPase Activity
Regulation Of Apoptotic Process
Regulation Of Cell Cycle
Execution Phase Of Apoptosis
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Fasting glucose-related traits (
20081858
)
Fasting glucose-related traits (interaction with BMI) (
22581228
)
HDL cholesterol (
19060911
)
Proinsulin levels (
21873549
)
Protein-protein Interactions
9 interactors:
NPDC1
PIDD1
POT1
PTPRN
TNFRSF10A
TNFRSF10B
TNFRSF1A
VPS13D
YWHAZ
Entrez ID
8567
HPRD ID
04664
Ensembl ID
ENSG00000110514
Uniprot IDs
Q8WXG6
PDB IDs
Enriched GO Terms of Interacting Partners
?
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Cellular Response To Mechanical Stimulus
Apoptotic Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity
Extrinsic Apoptotic Signaling Pathway
Zymogen Activation
Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Programmed Cell Death
Positive Regulation Of Cysteine-type Endopeptidase Activity
Cell Death
Death
Positive Regulation Of Endopeptidase Activity
Positive Regulation Of Peptidase Activity
Positive Regulation Of Signal Transduction
Intrinsic Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Response To Mechanical Stimulus
Regulation Of Apoptotic Process
Activation Of NF-kappaB-inducing Kinase Activity
Protein Processing
Regulation Of Cell Death
Positive Regulation Of NIK/NF-kappaB Signaling
NIK/NF-kappaB Signaling
Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Proteolysis
Intracellular Signal Transduction
Positive Regulation Of Hydrolase Activity
Regulation Of Endopeptidase Activity
Regulation Of Peptidase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Hormone Secretion
Positive Regulation Of DNA Strand Elongation
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Hormone Transport
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Dense Core Granule Maturation
Positive Regulation Of Transferase Activity
Regulation Of Signal Transduction
Positive Regulation Of Catalytic Activity
Telomere Formation Via Telomerase
TRAIL-activated Apoptotic Signaling Pathway
Regulation Of Proteolysis
Tagcloud
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abca1
abcg5
abcg8
atorvastatin
causal
challenging
chow
excised
fads1
gwas
hfd
hypertensive
list
loci
lpl
nominally
nr1h3
orthologs
overlapped
pcsk9
pltp
qpcr
qtl
responded
spontaneously
stac3
staged
suggestive
timd4