MADD and NPDC1

Number of citations of the paper that reports this interaction (PubMedID 10970871)
53

Data Source:
HPRD (in vitro, two hybrid)

		MADD	NPDC1
Description		MAP kinase activating death domain	neural proliferation, differentiation and control 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Axon Cell Projection	Plasma Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Death Receptor Binding Protein Binding Protein Kinase Activator Activity	Protein Binding
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Rab Protein Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) C-reactive protein levels ( 30388399) Chronic kidney disease ( 26831199) Chronotype ( 30696823) Corneal astigmatism ( 29422769) Fasting blood glucose ( 20081858 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 34059833) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 29891935) Glycemic traits (pleiotropy) ( 31021400) HDL cholesterol ( 25961943 19060911) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Insulin-related traits (multivariate analysis) ( 32002517) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Monocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Proinsulin levels ( 21873549) Refractive error ( 32231278)	Lymphocyte count ( 27863252) Monocyte percentage of white cells ( 27863252 32888494) White blood cell count ( 27863252 32888494)
Interacting Genes		12 interacting genes: NPDC1 PCNT PIDD1 POT1 PTPRN RB1CC1 RBM11 TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ	41 interacting genes: C3orf52 CCND1 CCND2 CCND3 CDK2 CPT1A CYSRT1 E2F1 EMD FHL5 HINFP HNRNPK KHDRBS2 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-1 KRTAP4-12 KRTAP4-4 KRTAP5-9 KRTAP9-3 MADD MAL MDFI MS4A13 NBPF19 NOTCH2NLA PLSCR1 RBMY1F RBMY1J TFDP1
Entrez ID		8567	56654
HPRD ID		04664	12048
Ensembl ID		ENSG00000110514	ENSG00000107281
Uniprot IDs		A0A0A0MRB5 A0A0U1RR25 A0A9L9PXF1 A0A9L9PXN0 A0A9L9PXZ0 A0A9L9PXZ3 A0A9L9PY18 A0A9L9PY22 Q8WXG6	Q9NQX5
PDB IDs
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Death Receptor Activity TRAIL Binding Cellular Response To Mechanical Stimulus TRAIL-activated Apoptotic Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Cell Death Programmed Cell Death Response To Mechanical Stimulus Activation Of Protein Kinase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death TRAIL Receptor Activity Ribophagy Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Signaling Receptor Activity Regulation Of Canonical NF-kappaB Signal Transduction Synaptic Target Recognition Positive Regulation Of Telomeric Loop Disassembly Dense Core Granule Maturation 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Endopeptidase Complex Response To Stress Secretory Granule Maturation Positive Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Telomeric D-loop Binding Telomere Assembly Protein Retention In Golgi Apparatus Cellular Response To Stress Golgi Reassembly Single-stranded Telomeric DNA Binding Positive Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Aortic Valve Development Semi-lunar Valve Development Phosphoserine Residue Binding Positive Regulation Of Kinase Activity Shelterin Complex Organelle Organization	Intermediate Filament Keratin Filament Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Cytosol Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of MRNA Processing Anoikis Positive Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Hair Cycle Protein Serine/threonine Kinase Activator Activity Identical Protein Binding Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Cell Cycle Regulation Of RNA Splicing Positive Regulation Of Cell Cycle Regulation Of MRNA Metabolic Process Regulation Of Mitotic Cell Cycle Microtubule Organizing Center Response To X-ray Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Cell Cycle Phase Transition Liver Regeneration TMEM240-body Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane
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