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MADD and PIDD1
Number of citations of the paper that reports this interaction (PMID
10825539
)
13
Data Source:
HPRD
(in vivo)
MADD
PIDD1
Gene Name
MAP-kinase activating death domain
p53-induced death domain protein 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Membrane
Nucleus
Cytoplasm
Golgi Apparatus
Molecular Function
Death Receptor Binding
Protein Binding
Rab Guanyl-nucleotide Exchange Factor Activity
Protein Kinase Activator Activity
Death Receptor Binding
Protein Binding
Biological Process
Activation Of MAPK Activity
Cell Surface Receptor Signaling Pathway
Regulation Of Rab Protein Signal Transduction
Positive Regulation Of Rab GTPase Activity
Regulation Of Apoptotic Process
Regulation Of Cell Cycle
Execution Phase Of Apoptosis
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
Drugs
Diseases
GWAS
Fasting glucose-related traits (
20081858
)
Fasting glucose-related traits (interaction with BMI) (
22581228
)
HDL cholesterol (
19060911
)
Proinsulin levels (
21873549
)
Protein-Protein Interactions
9 interactors:
NPDC1
PIDD1
POT1
PTPRN
TNFRSF10A
TNFRSF10B
TNFRSF1A
VPS13D
YWHAZ
12 interactors:
AFP
CASP2
CCDC85B
CRADD
EFEMP2
FADD
KEAP1
MADD
MAFG
MDFI
SOX8
TEAD3
Entrez ID
8567
55367
HPRD ID
04664
11284
Ensembl ID
ENSG00000110514
ENSG00000177595
Uniprot IDs
Q8WXG6
Q9HB75
PDB IDs
2OF5
Enriched GO Terms of Interacting Partners
?
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Cellular Response To Mechanical Stimulus
Apoptotic Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity
Extrinsic Apoptotic Signaling Pathway
Zymogen Activation
Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Programmed Cell Death
Positive Regulation Of Cysteine-type Endopeptidase Activity
Cell Death
Death
Positive Regulation Of Endopeptidase Activity
Positive Regulation Of Peptidase Activity
Positive Regulation Of Signal Transduction
Intrinsic Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Response To Mechanical Stimulus
Regulation Of Apoptotic Process
Activation Of NF-kappaB-inducing Kinase Activity
Protein Processing
Regulation Of Cell Death
Positive Regulation Of NIK/NF-kappaB Signaling
NIK/NF-kappaB Signaling
Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Proteolysis
Intracellular Signal Transduction
Positive Regulation Of Hydrolase Activity
Regulation Of Endopeptidase Activity
Regulation Of Peptidase Activity
Positive Regulation Of Cellular Protein Metabolic Process
Hormone Secretion
Positive Regulation Of DNA Strand Elongation
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Hormone Transport
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Dense Core Granule Maturation
Positive Regulation Of Transferase Activity
Regulation Of Signal Transduction
Positive Regulation Of Catalytic Activity
Telomere Formation Via Telomerase
TRAIL-activated Apoptotic Signaling Pathway
Regulation Of Proteolysis
Cellular Response To Mechanical Stimulus
Extrinsic Apoptotic Signaling Pathway
Regulation Of Cell Differentiation
Response To Stimulus
Reproductive Structure Development
Positive Regulation Of Cellular Metabolic Process
Reproductive System Development
In Utero Embryonic Development
Cellular Response To Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Cellular Protein Metabolic Process
Signal Transduction
Regulation Of Cysteine-type Endopeptidase Activity
Response To Mechanical Stimulus
Gonad Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Epidermal Cell Differentiation
Development Of Primary Sexual Characteristics
Protein Processing
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Signaling
Regulation Of Proteolysis
Regulation Of Cellular Process
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Reproductive Process
Cell Communication
Regulation Of Metabolic Process
Developmental Process Involved In Reproduction
Regulation Of Protein Metabolic Process
Neural Retina Development
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Sex Differentiation
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Proteolysis
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Chordate Embryonic Development
Regulation Of Apoptotic Process
Embryo Development Ending In Birth Or Egg Hatching
Regulation Of Epidermis Development
Positive Regulation Of Metabolic Process
Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation
Mitotic G1 DNA Damage Checkpoint
Regulation Of Cell Death
Apoptotic Signaling Pathway
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Tagcloud
?
abca1
abcg5
abcg8
atorvastatin
causal
challenging
chow
excised
fads1
gwas
hfd
hypertensive
list
loci
lpl
nominally
nr1h3
orthologs
overlapped
pcsk9
pltp
qpcr
qtl
responded
spontaneously
stac3
staged
suggestive
timd4
Tagcloud (Difference)
?
abca1
abcg5
abcg8
atorvastatin
causal
challenging
chow
excised
fads1
gwas
hfd
hypertensive
list
loci
lpl
nominally
nr1h3
orthologs
overlapped
pcsk9
pltp
qpcr
qtl
responded
spontaneously
stac3
staged
suggestive
timd4
Tagcloud (Intersection)
?