MADD and VPS13D

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		MADD	VPS13D
Gene Name		MAP-kinase activating death domain	vacuolar protein sorting 13 homolog D (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane	Intracellular Extrinsic Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Death Receptor Binding Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Protein Kinase Activator Activity
	Biological Process	Activation Of MAPK Activity Cell Surface Receptor Signaling Pathway Regulation Of Rab Protein Signal Transduction Positive Regulation Of Rab GTPase Activity Regulation Of Apoptotic Process Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Targeting To Vacuole Protein Retention In Golgi Apparatus
Pathways
Drugs
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 19060911) Proinsulin levels ( 21873549)
Protein-Protein Interactions		9 interactors: NPDC1 PIDD1 POT1 PTPRN TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ	1 interactors: MADD
Entrez ID		8567	55187
HPRD ID		04664	10593
Ensembl ID		ENSG00000110514	ENSG00000048707
Uniprot IDs		Q8WXG6	J3KP14 Q5THJ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Zymogen Activation Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Cell Death Death Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Response To Mechanical Stimulus Regulation Of Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Protein Processing Regulation Of Cell Death Positive Regulation Of NIK/NF-kappaB Signaling NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Proteolysis Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Hormone Secretion Positive Regulation Of DNA Strand Elongation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hormone Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Dense Core Granule Maturation Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Telomere Formation Via Telomerase TRAIL-activated Apoptotic Signaling Pathway Regulation Of Proteolysis
Tagcloud ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Difference) ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Intersection) ?