WIPI2 and CRYAA

Number of citations of the paper that reports this interaction (PubMedID 24453475)
30

Data Source:
BioGRID (pull down)

		WIPI2	CRYAA
Description		WD repeat domain, phosphoinositide interacting 2	crystallin alpha A
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleoplasm Autophagosome Cytosol Membrane Protein-containing Complex Phagophore Assembly Site Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Autophagy Response To Stress Cellular Response To Starvation Protein Localization To Phagophore Assembly Site Nucleophagy Glycophagy Autophagosome Maturation	Response To Hypoxia Lens Development In Camera-type Eye Lens Morphogenesis In Camera-type Eye Apoptotic Process Mitochondrion Organization Actin Filament Organization Microtubule-based Process Tubulin Complex Assembly Visual Perception Response To Heat Negative Regulation Of Gene Expression Positive Regulation Of Cell Growth Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Embryonic Camera-type Eye Morphogenesis Protein Stabilization Apoptotic Process Involved In Morphogenesis Response To UV-A Lens Fiber Cell Morphogenesis
Pathways		Macroautophagy
Drugs
Diseases
GWAS		Bone mineral density x blood lead interaction in current smokers (1df test) ( 29518117) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Red blood cell count ( 32888494)	Age-related nuclear cataracts ( 24951543 33311586) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Metabolite levels ( 23823483) Systolic blood pressure ( 27618452 27841878 28739976)
Interacting Genes		18 interacting genes: ARL6IP1 ATG16L1 COPS6 CRYAA DDB1 DGAT2L6 FKBP7 HUWE1 MRRF MTOR OPTN POT1 RABAC1 REEP6 RPTOR STRN4 SYP TERF2IP	134 interacting genes: - ADPRHL1 AKT3 ALB ALDH1L2 ANKRD44 APPL2 ARFGAP1 ARMCX4 ARRDC1-AS1 ATG16L1 BCL2L1 BORA BTRC CAMKK2 CD209 CDC40 CEBPZ CENPH CER1 CNOT8 COPB2 CRTAC1 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS CSTF2T DCAF11 DCAF8 DCK DDX3X DUS4L E2F7 EEPD1 ETFB EYA4 FAM131B FAM131C FAM182A FASN GIGYF2 GLYATL1 GNAI2 GORASP2 GSTZ1 HABP4 HCLS1 HSPB1 HSPB2 IGHG1 IGKV1-5 JKAMP KBTBD12 KIZ KNG1 LALBA LARP6 LIMA1 MAP3K7CL MAPKBP1 MCM7 MCRS1 MINDY1 MIP MPHOSPH6 MTERF4 MYO5C NAT9 NCF4 NTAQ1 NUP43 OSBPL3 OTOGL OTULIN PABIR2 PAFAH1B1 PCYT2 PHC1 PLAUR PMS2 PRM2 PSMB6 PTPN2 PTTG2 QRICH1 RAB24 RAB29 RAB3C RAB40B RAB43 RAD51 RBBP7 RNASEH1 RNGTT RPS6KA5 SDCBP SEC24C SEH1L SESN2 SGCD SLC20A1 SLC25A25 SLC25A26 SLC25A28 SPG21 SSBP4 SULF1 SYK TASL TEAD4 TFDP1 TGOLN2 TLE4 TMEM254 TMEM52B TSR3 TTC27 TTC39B TUBAL3 TUBGCP5 UBR2 UPP1 WDR55 WDR83 WIPI2 WWC2 ZIM2 ZNF3 ZNF639 ZSCAN20
Entrez ID		26100	1409
HPRD ID		15679	00427
Ensembl ID		ENSG00000157954	ENSG00000160202
Uniprot IDs		Q9Y4P8	A0A8C8KJZ9 P02489
PDB IDs		7F69 7MU2 7XFR	6T1R
Enriched GO Terms of Interacting Partners?		Organelle Organization Positive Regulation Of Catabolic Process Positive Regulation Of Pentose-phosphate Shunt TORC1 Complex Regulation Of Pentose-phosphate Shunt Shelterin Complex Regulation Of NADP Metabolic Process Positive Regulation Of Autophagy Regulation Of Autophagy Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Regulation Of Cellular Component Organization Protein-macromolecule Adaptor Activity Cellular Response To L-leucine Telomere Capping Response To L-leucine Autophagosome Assembly Positive Regulation Of Transcription By RNA Polymerase III Autophagosome Organization Serine/threonine Protein Kinase Complex Positive Regulation Of Glycolytic Process Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase III Telomeric DNA Binding Protein-containing Complex Binding Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Growth Positive Regulation Of Small Molecule Metabolic Process Macroautophagy Regulation Of Cell Growth Chromosome, Telomeric Region Vacuole Organization Positive Regulation Of ATP Metabolic Process GTPase Binding Negative Regulation Of Telomere Maintenance DNA Damage Response Negative Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Vacuole-isolation Membrane Contact Site Negative Regulation Of Translational Initiation Cellular Response To Osmotic Stress Positive Regulation Of Translational Initiation Identical Protein Binding Regulation Of Glycolytic Process Cytoplasmic Vesicle	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye
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