WIPI2 and DGAT2L6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		WIPI2	DGAT2L6
Description		WD repeat domain, phosphoinositide interacting 2	diacylglycerol O-acyltransferase 2 like 6
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleoplasm Autophagosome Cytosol Membrane Protein-containing Complex Phagophore Assembly Site Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Diacylglycerol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Autophagy Response To Stress Cellular Response To Starvation Protein Localization To Phagophore Assembly Site Nucleophagy Glycophagy Autophagosome Maturation	Lipid Metabolic Process Monoacylglycerol Biosynthetic Process Acylglycerol Acyl-chain Remodeling
Pathways		Macroautophagy	Acyl chain remodeling of DAG and TAG
Drugs
Diseases
GWAS		Bone mineral density x blood lead interaction in current smokers (1df test) ( 29518117) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Red blood cell count ( 32888494)
Interacting Genes		18 interacting genes: ARL6IP1 ATG16L1 COPS6 CRYAA DDB1 DGAT2L6 FKBP7 HUWE1 MRRF MTOR OPTN POT1 RABAC1 REEP6 RPTOR STRN4 SYP TERF2IP	45 interacting genes: ABHD4 ABHD5 ACSF2 AQP6 ARFIP2 BNIP2 CIAO2A DIABLO ECPAS FARS2 FBXL19 FCER1G GAD2 GPR152 HSD17B11 MCEMP1 MPP1 MTERF4 MYG1 NAPB NDRG4 PBX3 PGRMC2 PITPNC1 REEP4 RNF144A RNF5 RUSF1 SCAND1 SCN3B SLC10A1 SLC10A6 SMG9 SNX4 STAR THAP4 TMED8 TMEM143 TMEM14B TMEM255B TMEM31 TMX2 TTPA TUFM WIPI2
Entrez ID		26100	347516
HPRD ID		15679	13141
Ensembl ID		ENSG00000157954	ENSG00000184210
Uniprot IDs		Q9Y4P8	Q6ZPD8
PDB IDs		7F69 7MU2 7XFR
Enriched GO Terms of Interacting Partners?		Organelle Organization Positive Regulation Of Catabolic Process Positive Regulation Of Pentose-phosphate Shunt TORC1 Complex Regulation Of Pentose-phosphate Shunt Shelterin Complex Regulation Of NADP Metabolic Process Positive Regulation Of Autophagy Regulation Of Autophagy Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Regulation Of Cellular Component Organization Protein-macromolecule Adaptor Activity Cellular Response To L-leucine Telomere Capping Response To L-leucine Autophagosome Assembly Positive Regulation Of Transcription By RNA Polymerase III Autophagosome Organization Serine/threonine Protein Kinase Complex Positive Regulation Of Glycolytic Process Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase III Telomeric DNA Binding Protein-containing Complex Binding Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Growth Positive Regulation Of Small Molecule Metabolic Process Macroautophagy Regulation Of Cell Growth Chromosome, Telomeric Region Vacuole Organization Positive Regulation Of ATP Metabolic Process GTPase Binding Negative Regulation Of Telomere Maintenance DNA Damage Response Negative Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Vacuole-isolation Membrane Contact Site Negative Regulation Of Translational Initiation Cellular Response To Osmotic Stress Positive Regulation Of Translational Initiation Identical Protein Binding Regulation Of Glycolytic Process Cytoplasmic Vesicle
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