WIPI2 and HUWE1

Number of citations of the paper that reports this interaction (PubMedID 30340022)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		WIPI2	HUWE1
Description		WD repeat domain, phosphoinositide interacting 2	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Phagophore Assembly Site Nucleoplasm Autophagosome Cytosol Membrane Protein-containing Complex Phagophore Assembly Site Membrane	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Histone Ubiquitin Ligase Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Autophagy Response To Stress Cellular Response To Starvation Protein Localization To Phagophore Assembly Site Nucleophagy Glycophagy Autophagosome Maturation	Protein Polyubiquitination DNA Repair Base-excision Repair Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Golgi Organization Canonical NF-kappaB Signal Transduction Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Membrane Fusion Protein K48-linked Ubiquitination Protein Branched Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Type 2 Mitophagy
Pathways		Macroautophagy	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bone mineral density x blood lead interaction in current smokers (1df test) ( 29518117) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Red blood cell count ( 32888494)	Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)
Interacting Genes		18 interacting genes: ARL6IP1 ATG16L1 COPS6 CRYAA DDB1 DGAT2L6 FKBP7 HUWE1 MRRF MTOR OPTN POT1 RABAC1 REEP6 RPTOR STRN4 SYP TERF2IP	41 interacting genes: ABL1 ATOH1 CALM1 CASP1 CCL1 CD274 CDKN2A CLIC6 CREBBP CUL4B DDIT4 ERG H2AX H2BC3 LAPTM5 MCL1 MYCN NRIP1 PCNT PIAS2 POLB POLL PPP5C PTOV1 RNF10 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBA6 UBC UBE2D1 UBE2D2 UBE2G1 UBE2L3 UBE2Z WBP2 WIPI2
Entrez ID		26100	10075
HPRD ID		15679	06608
Ensembl ID		ENSG00000157954	ENSG00000086758
Uniprot IDs		Q9Y4P8	Q7Z6Z7
PDB IDs		7F69 7MU2 7XFR	2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL 7AZX 7JQ9 7MOP 7MWD 7MWE 7MWF 8R7O 8RD0 8RD1 8RD7
Enriched GO Terms of Interacting Partners?		Organelle Organization Positive Regulation Of Catabolic Process Positive Regulation Of Pentose-phosphate Shunt TORC1 Complex Regulation Of Pentose-phosphate Shunt Shelterin Complex Regulation Of NADP Metabolic Process Positive Regulation Of Autophagy Regulation Of Autophagy Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Regulation Of Cellular Component Organization Protein-macromolecule Adaptor Activity Cellular Response To L-leucine Telomere Capping Response To L-leucine Autophagosome Assembly Positive Regulation Of Transcription By RNA Polymerase III Autophagosome Organization Serine/threonine Protein Kinase Complex Positive Regulation Of Glycolytic Process Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase III Telomeric DNA Binding Protein-containing Complex Binding Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Growth Positive Regulation Of Small Molecule Metabolic Process Macroautophagy Regulation Of Cell Growth Chromosome, Telomeric Region Vacuole Organization Positive Regulation Of ATP Metabolic Process GTPase Binding Negative Regulation Of Telomere Maintenance DNA Damage Response Negative Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Vacuole-isolation Membrane Contact Site Negative Regulation Of Translational Initiation Cellular Response To Osmotic Stress Positive Regulation Of Translational Initiation Identical Protein Binding Regulation Of Glycolytic Process Cytoplasmic Vesicle	Post-translational Protein Modification Protein Modification Process Nucleoplasm Protein Modification By Small Protein Conjugation Protein-containing Complex Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Modification-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stress DNA Damage Response Protein Metabolic Process Negative Regulation Of Gliogenesis Intrinsic Apoptotic Signaling Pathway Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Enzyme Binding Protein Polyubiquitination Regulation Of Transcription By RNA Polymerase II Chromatin Ubiquitin-dependent Protein Catabolic Process Cytosol RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Apoptotic Signaling Pathway DNA Binding SUMO Transferase Activity Double-strand Break Repair Damaged DNA Binding Signal Transduction Catabolic Process DNA Repair SMAD Protein Signal Transduction Disordered Domain Specific Binding Regulation Of RNA Metabolic Process
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