TPP1 and STN1

Number of citations of the paper that reports this interaction (PubMedID 25172512)
38

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TPP1	STN1
Description		tripeptidyl peptidase 1	STN1 subunit of CST complex
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GO Annotations	Cellular Component	Lysosome Golgi Apparatus Melanosome Lysosomal Lumen Membrane Raft Recycling Endosome Extracellular Exosome	Chromosome, Telomeric Region Fibrillar Center Nucleus Nucleoplasm Chromosome Intermediate Filament Cytoskeleton CST Complex
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Hydrolase Activity Lysophosphatidic Acid Binding Peptide Binding Metal Ion Binding Sulfatide Binding	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding Protein Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding
	Biological Process	Proteolysis Lipid Metabolic Process Lysosome Organization Nervous System Development Central Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation Peptide Catabolic Process Bone Resorption Neuromuscular Process Controlling Balance Protein Localization To Chromosome, Telomeric Region Lysosomal Protein Catabolic Process	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Replication Regulation Of DNA Metabolic Process
Pathways		XBP1(S) activates chaperone genes	Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Malaria ( 31844061)	Chronic obstructive pulmonary disease ( 30804561) Leukocyte telomere length ( 32109421) Myocardial infarction ( 33532862) Systemic lupus erythematosus ( 33272962) Telomere length ( 33941849) Uterine fibroids ( 30194396 31488892) White matter integrity (mean diffusivity) ( 32358547)
Interacting Genes		9 interacting genes: CTC1 DSCR9 LCOR NMB OGT POT1 STN1 TERT TINF2	18 interacting genes: AIRIM APP C14orf119 CDK3 GOLGA2 LRRK2 MFHAS1 MKRN3 MVP NTAQ1 RCOR3 TEN1 TOLLIP TPP1 TRIML2 TUBGCP4 TXN2 ZDHHC17
Entrez ID		1200	79991
HPRD ID		06415	14872
Ensembl ID		ENSG00000166340	ENSG00000107960
Uniprot IDs		O14773	Q9H668
PDB IDs		3EDY 3EE6	4JOI 4JQF 6W6W 7U5C 8D0B 8D0K 8SOJ 8SOK
Enriched GO Terms of Interacting Partners?		Telomeric DNA Binding Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome, Telomeric Region Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Chromosome Organization Negative Regulation Of DNA Metabolic Process CST Complex Telomere Assembly Single-stranded Telomeric DNA Binding Shelterin Complex Regulation Of Chromosome Organization Establishment Of Protein Localization To Telomere Positive Regulation Of DNA Metabolic Process Chromosome G-rich Strand Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Biosynthetic Process DNA Metabolic Process Negative Regulation Of Biosynthetic Process Replicative Senescence Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process RNA-templated DNA Biosynthetic Process Regulation Of DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process DNA Binding Positive Regulation Of DNA Replication Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Neuromedin B Receptor Binding TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription	Golgi-associated Vesicle Protein Metabolic Process Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Recycling Endosome Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Notch Signaling Pathway Microtubule Nucleation Perforant Pathway To Dendrate Granule Cell Synapse Protein-N-terminal Glutamine Amidohydrolase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Negative Regulation Of Protein Localization To Nucleus
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