TPP1 and CTC1

Number of citations of the paper that reports this interaction (PubMedID 25172512)
38

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TPP1	CTC1
Description		tripeptidyl peptidase 1	CST telomere replication complex component 1
Image
GO Annotations	Cellular Component	Lysosome Golgi Apparatus Melanosome Lysosomal Lumen Membrane Raft Recycling Endosome Extracellular Exosome	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytosol CST Complex
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Hydrolase Activity Lysophosphatidic Acid Binding Peptide Binding Metal Ion Binding Sulfatide Binding	DNA Binding Single-stranded DNA Binding Protein Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Proteolysis Lipid Metabolic Process Lysosome Organization Nervous System Development Central Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation Peptide Catabolic Process Bone Resorption Neuromuscular Process Controlling Balance Protein Localization To Chromosome, Telomeric Region Lysosomal Protein Catabolic Process	Telomere Maintenance DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Multicellular Organism Growth Positive Regulation Of DNA Replication Positive Regulation Of Fibroblast Proliferation Spleen Development Thymus Development Bone Marrow Development Chromosome Organization Hematopoietic Stem Cell Proliferation Replicative Senescence
Pathways		XBP1(S) activates chaperone genes	Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Malaria ( 31844061)	Bipolar disorder ( 28115744) Telomere length ( 23001564)
Interacting Genes		9 interacting genes: CTC1 DSCR9 LCOR NMB OGT POT1 STN1 TERT TINF2	2 interacting genes: APPBP2 TPP1
Entrez ID		1200	80169
HPRD ID		06415	07980
Ensembl ID		ENSG00000166340	ENSG00000178971
Uniprot IDs		O14773	A0A8V8TP86 A0A8V8TQB6 J3KSZ1 Q2NKJ3
PDB IDs		3EDY 3EE6	5W2L 6W6W 7U5C 8D0B 8D0K 8SOJ 8SOK
Enriched GO Terms of Interacting Partners?		Telomeric DNA Binding Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome, Telomeric Region Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Chromosome Organization Negative Regulation Of DNA Metabolic Process CST Complex Telomere Assembly Single-stranded Telomeric DNA Binding Shelterin Complex Regulation Of Chromosome Organization Establishment Of Protein Localization To Telomere Positive Regulation Of DNA Metabolic Process Chromosome G-rich Strand Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Biosynthetic Process DNA Metabolic Process Negative Regulation Of Biosynthetic Process Replicative Senescence Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process RNA-templated DNA Biosynthetic Process Regulation Of DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process DNA Binding Positive Regulation Of DNA Replication Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Neuromedin B Receptor Binding TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription	Protein Localization To Chromosome, Telomeric Region Lysosomal Protein Catabolic Process Sulfatide Binding Peptide Catabolic Process Protein Catabolic Process Lysophosphatidic Acid Binding Tripeptidyl-peptidase Activity Protein Catabolic Process In The Vacuole Cul2-RING Ubiquitin Ligase Complex Bone Resorption Macromolecule Catabolic Process Peptide Binding Microtubule Associated Complex Proteolysis Neuromuscular Process Controlling Balance Lysosome Organization Peptide Metabolic Process Microtubule Motor Activity Protein Localization To Chromosome Intracellular Protein Localization Melanosome Neuromuscular Process Catabolic Process Endopeptidase Activity Lysosomal Lumen Ubiquitin-like Ligase-substrate Adaptor Activity Serine-type Peptidase Activity
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