TPP1 and TINF2

Number of citations of the paper that reports this interaction (PMID 25172512)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TPP1	TINF2
Gene Name		tripeptidyl peptidase I	TERF1 (TRF1)-interacting nuclear factor 2
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Lysosome Melanosome Lysosomal Lumen Extracellular Vesicular Exosome	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Peptide Binding Metal Ion Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Proteolysis Lipid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Lysosome Organization Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Peptide Catabolic Process Cellular Protein Metabolic Process Bone Resorption Neuromuscular Process Controlling Balance	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein ADP-ribosylation Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CTC1 NMB OBFC1 POT1 TERT TINF2	88 interactors: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFRL1 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM POT1 PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		1200	26277
HPRD ID		06415	16056
Ensembl ID		ENSG00000166340	ENSG00000092330
Uniprot IDs		O14773	B4DFJ1 Q9BSI4
PDB IDs		1R60 3EDY 3EE6	3BQO 3BU8
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Telomere Assembly Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Homeostatic Process Telomere Formation Via Telomerase Positive Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization DNA Metabolic Process Negative Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Replicative Senescence Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Replication Cell Aging Negative Regulation Of Chromosome Organization Organelle Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Negative Regulation Of Production Of SiRNA Involved In RNA Interference Positive Regulation Of Metabolic Process Negative Regulation Of RNA Interference Regulation Of Protein ADP-ribosylation Transcription, RNA-templated Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Negative Regulation Of Protein Glycosylation Regulation Of Chromosome Organization Nucleobase-containing Compound Metabolic Process Positive Regulation Of Helicase Activity Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Bone Marrow Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process DNA Replication Cellular Nitrogen Compound Metabolic Process Replicative Cell Aging Negative Regulation Of Telomerase Activity Regulation Of Protein Glycosylation	Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Glycolytic Process Protection From Non-homologous End Joining At Telomere Carbohydrate Catabolic Process Negative Regulation Of DNA Replication Telomere Assembly Catabolic Process Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Catalytic Activity Positive Regulation Of Telomerase Activity Pyruvate Metabolic Process Telomere Maintenance Telomere Maintenance Via Telomerase Pathogenesis Generation Of Precursor Metabolites And Energy Glucose Metabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Catalytic Activity Carboxylic Acid Metabolic Process Age-dependent Telomere Shortening Telomeric Loop Formation Nervous System Development Regulation Of Signaling Positive Regulation Of DNA Biosynthetic Process Glycogen Metabolic Process RNA-dependent DNA Replication Nucleoside Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Signal Transduction Hexose Metabolic Process Cellular Process Regulation Of DNA Replication Monocarboxylic Acid Metabolic Process Cellular Carbohydrate Metabolic Process Response To Stimulus Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomere Lengthening Polysaccharide Metabolic Process
Tagcloud ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum pot1 propodium ptop telomere telomeric tint1 trastuzumab trf2 trf2ip	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Difference) ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 trastuzumab trf2 trf2ip	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Intersection) ?		pot1