TPP1

Gene Name		tripeptidyl peptidase I
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Lysosome Melanosome Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Peptide Binding Metal Ion Binding
	Biological Process	Proteolysis Lipid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Lysosome Organization Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Peptide Catabolic Process Cellular Protein Metabolic Process Bone Resorption Neuromuscular Process Controlling Balance
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: CTC1 NMB OBFC1 POT1 TERT TINF2
Entrez ID		1200
HPRD ID		06415
Ensembl ID		ENSG00000166340
Uniprot IDs		O14773
PDB IDs		1R60 3EDY 3EE6
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Telomere Assembly Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Homeostatic Process Telomere Formation Via Telomerase Positive Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization DNA Metabolic Process Negative Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Replicative Senescence Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Replication Cell Aging Negative Regulation Of Chromosome Organization Organelle Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Negative Regulation Of Production Of SiRNA Involved In RNA Interference Positive Regulation Of Metabolic Process Negative Regulation Of RNA Interference Regulation Of Protein ADP-ribosylation Transcription, RNA-templated Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Negative Regulation Of Protein Glycosylation Regulation Of Chromosome Organization Nucleobase-containing Compound Metabolic Process Positive Regulation Of Helicase Activity Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Bone Marrow Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process DNA Replication Cellular Nitrogen Compound Metabolic Process Replicative Cell Aging Negative Regulation Of Telomerase Activity Regulation Of Protein Glycosylation
Tagcloud ?		0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum pot1 propodium ptop telomere telomeric tint1 trastuzumab trf2 trf2ip