ACOT7 and POU6F1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACOT7	POU6F1
Description		acyl-CoA thioesterase 7	POU class 6 homeobox 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Fatty-acyl-CoA Binding Protein Binding Hydrolase Activity Thiolester Hydrolase Activity Long-chain Fatty Acyl-CoA Binding Protein Homodimerization Activity Fatty Acyl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Long-chain Fatty Acyl-CoA Hydrolase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Fatty Acid Catabolic Process Coenzyme A Biosynthetic Process Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process Medium-chain Fatty Acid Biosynthetic Process Palmitic Acid Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Heart Development Muscle Organ Development
Pathways		Mitochondrial Fatty Acid Beta-Oxidation
Drugs
Diseases
GWAS		A body shape index ( 34021172) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) HDL cholesterol levels in HIV infection ( 33109212) Metabolite levels ( 31628463) QT interval ( 19305408) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Adult body size ( 32376654) Cisplatin-induced ototoxicity ( 28039263) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		26 interacting genes: ACOT12 ATXN1 ATXN1L BAG4 CAMK2B CDC42 CRYAB DAZAP2 DLC1 ENKD1 FXR1 HOXA1 LMNA MAGEA3 MAGEA6 NCOA5 POT1 POU6F1 SPATC1L TERF1 THAP1 TINF2 UBQLN1 UBQLN2 UBXN1 ZNF438	3 interacting genes: ACOT7 ERBB2 NFYC
Entrez ID		11332	5463
HPRD ID		12517	17883
Ensembl ID		ENSG00000097021	ENSG00000184271
Uniprot IDs		O00154	B3KT91 Q14863
PDB IDs		2QQ2	3D1N
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Shelterin Complex Negative Regulation Of Metabolic Process Nuclear Telomere Cap Complex Identical Protein Binding Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Telomere Capping Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Cellular Component Organization Nucleus Regulation Of ERAD Pathway Telomeric DNA Binding Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Telomere Maintenance Via Telomere Lengthening POZ Domain Binding Negative Regulation Of DNA Biosynthetic Process Telomere Assembly Regulation Of Metabolic Process Nuclear Pore Localization Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Polyubiquitin Modification-dependent Protein Binding Muscle Organ Development Regulation Of Telomere Maintenance Via Telomerase Muscle Structure Development Negative Regulation Of DNA-templated Transcription Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of RNA Biosynthetic Process Cellular Component Assembly Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Organelle Organization Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of Organelle Organization Regulation Of DNA Biosynthetic Process Positive Regulation Of ERAD Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Stress Fiber Assembly Regulation Of Chromosome Organization Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Telomere Maintenance Via Telomerase	Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway CCAAT-binding Factor Complex Long-chain Fatty Acyl-CoA Binding Medium-chain Fatty Acid Biosynthetic Process Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process Palmitic Acid Biosynthetic Process Fatty-acyl-CoA Catabolic Process Medium-chain Fatty-acyl-CoA Metabolic Process Negative Regulation Of Immature T Cell Proliferation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-EGFR Signaling Pathway Protein Heterodimerization Activity ERBB4 Signaling Pathway Thiolester Hydrolase Activity Medium-chain Fatty Acid Metabolic Process Coenzyme A Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Semaphorin Receptor Complex Regulation Of Immature T Cell Proliferation In Thymus Long-chain Fatty Acyl-CoA Hydrolase Activity Fatty-acyl-CoA Binding Coenzyme A Metabolic Process Fatty Acyl-CoA Hydrolase Activity Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Motor Neuron Axon Guidance Peripheral Nervous System Development Regulation Of T Cell Differentiation In Thymus ERBB2 Signaling Pathway Positive Regulation Of Protein Targeting To Membrane Long-chain Fatty-acyl-CoA Metabolic Process Positive Regulation Of Rho Protein Signal Transduction Protein Localization To Postsynapse Regulation Of Protein Targeting To Membrane Protein Localization To Postsynaptic Membrane Positive Regulation Of Transcription By RNA Polymerase I Myelin Sheath Positive Regulation Of MAP Kinase Activity Neuromuscular Junction Development Long-chain Fatty Acid Biosynthetic Process Carboxylic Ester Hydrolase Activity Oligodendrocyte Differentiation Regulation Of Transcription By RNA Polymerase I
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