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TXN2 and MLH1
Number of citations of the paper that reports this interaction (PMID
20706999
)
2
Data Source:
BioGRID
(two hybrid)
TXN2
MLH1
Gene Name
thioredoxin 2
mutL homolog 1
Image
Gene Ontology Annotations
Cellular Component
Nucleolus
Mitochondrion
Mitochondrial Matrix
Dendrite
Neuronal Cell Body
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chiasma
Membrane
MutLalpha Complex
Molecular Function
Peptide-methionine (S)-S-oxide Reductase Activity
Protein Disulfide Oxidoreductase Activity
Protein Complex Binding
Peptide-methionine (R)-S-oxide Reductase Activity
Single-stranded DNA Binding
Protein Binding
ATP Binding
ATPase Activity
Guanine/thymine Mispair Binding
MutSalpha Complex Binding
Biological Process
Response To Reactive Oxygen Species
Response To Hypoxia
Glycerol Ether Metabolic Process
Response To Nutrient
Response To Hormone
Response To Glucose
Response To Organic Cyclic Compound
Cellular Response To Nutrient Levels
Response To Drug
Cell Redox Homeostasis
Response To Axon Injury
Oxidation-reduction Process
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Resolution Of Meiotic Recombination Intermediates
DNA Repair
Mismatch Repair
Double-strand Break Repair Via Nonhomologous End Joining
Male Meiosis Chromosome Segregation
Synapsis
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Somatic Hypermutation Of Immunoglobulin Genes
Meiotic Metaphase I Plate Congression
Isotype Switching
Negative Regulation Of Mitotic Recombination
Oogenesis
Meiotic Spindle Midzone Assembly
Pathways
Detoxification of Reactive Oxygen Species
Meiotic recombination
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions
34 interactors:
AGTRAP
ALDOB
AP2B1
CCDC114
DCTD
FAM9B
GPRASP2
KRT18
KRT40
MAGEA11
MAPRE2
MAPRE3
MLH1
MRFAP1L1
MTUS2
PPCDC
PSME3
RABAC1
RABGEF1
RBM45
REEP6
RPIA
SCYL3
SHARPIN
SSNA1
STUB1
THAP1
TIFA
TRIM21
TRIP6
UCHL5
VIM
VPS52
ZBTB14
74 interactors:
ABCC3
ABHD16A
ACER3
ACTG2
AGR2
AIFM1
ALDOA
ANXA6
AP2B1
APRT
ARAF
ASS1
ATF2
BLM
BRCA1
CAB39L
CAPN5
CASP3
CKAP4
CKB
CXorf57
DDX47
EEF1G
EEF2
EIF2A
ELP6
EXO1
EXOC3
FBXO32
FCGBP
FLNB
FRMD6
GABARAP
GSTP1
IGKC
KPNA2
LGALS4
MAP2K6
MBD4
MLH3
MSH3
MSH4
MUC2
MYC
MYL6
MYOG
NDRG1
NT5C3B
ORC4
PARP12
PARVA
PCNA
PMS1
PMS2
PSMA1
PTGDS
PTPRH
RAD23B
RAD9A
RAPGEFL1
SEC61A1
SELENBP1
SERPINF1
SPERT
SQSTM1
STAP2
TRIM23
TRIM29
TXN
TXN2
UBOX5
VAMP8
ZC3H11A
ZER1
Entrez ID
25828
4292
HPRD ID
07161
00390
Ensembl ID
ENSG00000100348
ENSG00000076242
Uniprot IDs
B4DX69
Q99757
P40692
Q59EG3
PDB IDs
1UVZ
1W4V
1W89
3NA3
3RBN
Enriched GO Terms of Interacting Partners
?
Protein Polyubiquitination
Cell Cycle
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Protein Autoubiquitination
Negative Regulation Of Kit Signaling Pathway
Meiotic Metaphase I Plate Congression
Golgi To Plasma Membrane CFTR Protein Transport
Meiotic Spindle Midzone Assembly
Regulation Of Proteasomal Protein Catabolic Process
I-kappaB Kinase/NF-kappaB Signaling
Signal Transduction
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Negative Regulation Of Mitotic Recombination
Positive Regulation Of Microtubule Plus-end Binding
Fructose Catabolic Process
Embryonic Ectodermal Digestive Tract Development
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Viral Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Ubiquitin-protein Transferase Activity
Execution Phase Of Apoptosis
Nucleotide Metabolic Process
Positive Regulation Of Ligase Activity
Negative Regulation Of Protein Deubiquitination
Regulation Of CD40 Signaling Pathway
Protein Linear Polyubiquitination
Positive Regulation Of Cell Cycle
Apoptotic Process
Signaling
Nicotinamide Nucleotide Metabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Mitotic Recombination
Pentose-phosphate Shunt, Non-oxidative Branch
Fructose 1,6-bisphosphate Metabolic Process
Male Meiosis Chromosome Segregation
Positive Regulation Of Viral Entry Into Host Cell
Programmed Cell Death
Cell Communication
Protein Complex Assembly
Cell Cycle Process
Regulation Of Cytokine-mediated Signaling Pathway
Cell Death
Nucleobase-containing Small Molecule Metabolic Process
Death
Negative Regulation Of Interleukin-6 Secretion
Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway
Cellular Response To Stress
Cellular Response To DNA Damage Stimulus
Cellular Response To Stimulus
Response To Stimulus
Mismatch Repair
Response To Stress
DNA Metabolic Process
DNA Catabolic Process
DNA Recombination
Negative Regulation Of Cell Cycle
DNA Repair
Cell Cycle
Cell Cycle Process
Cellular Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Response To Organic Substance
DNA Damage Checkpoint
Mitotic DNA Damage Checkpoint
Mucus Secretion
Regulation Of Cell Cycle
Mitotic DNA Integrity Checkpoint
Nitrogen Compound Metabolic Process
Cellular Response To Organic Substance
Apoptotic Process
Programmed Cell Death
Nucleic Acid Phosphodiester Bond Hydrolysis
Cell Death
Death
Response To Abiotic Stimulus
Cell Cycle Checkpoint
Apoptotic Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Cellular Response To Dexamethasone Stimulus
Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Response To Dexamethasone
Homeostatic Process
Mitotic Cell Cycle Checkpoint
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Catabolic Process, Exonucleolytic
Somatic Recombination Of Immunoglobulin Gene Segments
G2 DNA Damage Checkpoint
DNA Catabolic Process, Endonucleolytic
Regulation Of Apoptotic DNA Fragmentation
Somatic Diversification Of Immunoglobulins
Reciprocal Meiotic Recombination
Anatomical Structure Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Actin-mediated Cell Contraction
Tagcloud
?
9p24
actionable
arid1a
atlas
barr
bystander
cd274
cdkn2a
classifier
comes
comprises
cpg
ebv
enrollment
epstein
fail
gastrogenus
genomically
harbor
innocent
instability
intimately
l2
lytic
microsatellite
msi
noncoding
pdcd1lg2
qualify
Tagcloud (Difference)
?
9p24
actionable
arid1a
atlas
barr
bystander
cd274
cdkn2a
classifier
comes
comprises
cpg
ebv
enrollment
epstein
fail
gastrogenus
genomically
harbor
innocent
instability
intimately
l2
lytic
microsatellite
msi
noncoding
pdcd1lg2
qualify
Tagcloud (Intersection)
?