TXN2 and ETHE1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TXN2	ETHE1
Description		thioredoxin 2	ETHE1 persulfide dioxygenase
Image
GO Annotations	Cellular Component	Nucleolus Mitochondrion Mitochondrial Matrix	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Protein-disulfide Reductase Activity	Iron Ion Binding Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Sulfur Dioxygenase Activity Dioxygenase Activity
	Biological Process	Cell Redox Homeostasis	Glutathione Metabolic Process Hydrogen Sulfide Metabolic Process
Pathways		Degradation of cysteine and homocysteine Detoxification of Reactive Oxygen Species	Sulfide oxidation to sulfate
Drugs
Diseases
GWAS
Interacting Genes		78 interacting genes: ABI3 AGTRAP ALDOB ANKRD36B AP2B1 BCAS2 CCDC197 CDCA4 CEP70 CGGBP1 CHMP1A CIB4 CRACR2B CSTPP1 DCTD DDIT3 ETHE1 FAM9B FHL5 GOLGA6L9 GPRASP2 GPRASP3 GTPBP2 GUCD1 HAUS1 HAUS8 KAZN KRT18 KRT27 KRT40 LCN2 MAGEA11 MAGEA4 MAGEB2 MAPRE2 MAPRE3 MDFI MEOX2 MIPOL1 MLH1 MRFAP1 MRFAP1L1 MTUS2 MYL9 NUTM1 ODAD1 PEX19 POMC PPCDC PPP1R16B PSME3 RABAC1 RABGEF1 RBM45 REEP6 RPIA SAT1 SCYL3 SHARPIN SPTA1 SSNA1 STN1 STUB1 SYCE1 TFIP11 THAP1 TIFA TMOD4 TRIM21 TRIP6 TTC32 UCHL5 UQCC2 VIM VPS52 ZBTB14 ZMYND12 ZSCAN32	9 interacting genes: APP ATG9A ATP6V1H GORASP2 IGSF21 KRTAP19-2 LRIF1 RELA TXN2
Entrez ID		25828	23474
HPRD ID		07161	09764
Ensembl ID		ENSG00000100348	ENSG00000105755
Uniprot IDs		Q99757	A0A0S2Z580 A0A0S2Z5B3 A0A0S2Z5N8 B2RCZ7 O95571
PDB IDs		1UVZ 1W4V 1W89	4CHL
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Microtubule Organizing Center Organelle Organization Cytoskeleton Organization Cytoskeleton Membraneless Organelle Assembly Spindle Assembly Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Synaptonemal Complex Microtubule Cytoskeleton Organization Cytoplasm Microtubule-based Process	Negative Regulation Of MiRNA Transcription Positive Regulation Of Amyloid Precursor Protein Catabolic Process Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Positive Regulation Of Interleukin-1 Production Response To Interleukin-1 Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Synaptic Membrane Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Regulation Of Interleukin-1 Production Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of Interleukin-6 Production Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Interleukin-1 Beta Production Lipoprotein Particle Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Regulation Of Interleukin-1 Beta Production NF-kappaB P50/p65 Complex Positive Regulation Of Schwann Cell Differentiation Response To Cobalamin Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Response To Purine-containing Compound Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Recycling Endosome Positive Regulation Of Amyloid Fibril Formation
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