TXN2 and RABGEF1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TXN2	RABGEF1
Gene Name		thioredoxin 2	RAB guanine nucleotide exchange factor (GEF) 1
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body	Early Endosome Vesicle Recycling Endosome
	Molecular Function	Peptide-methionine (S)-S-oxide Reductase Activity Protein Disulfide Oxidoreductase Activity Protein Complex Binding Peptide-methionine (R)-S-oxide Reductase Activity	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Response To Reactive Oxygen Species Response To Hypoxia Glycerol Ether Metabolic Process Response To Nutrient Response To Hormone Response To Glucose Response To Organic Cyclic Compound Cellular Response To Nutrient Levels Response To Drug Cell Redox Homeostasis Response To Axon Injury Oxidation-reduction Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Protein Ubiquitination Positive Regulation Of Rab GTPase Activity Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Kit Signaling Pathway
Pathways		Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS			Aortic root size ( 21223598)
Protein-Protein Interactions		34 interactors: AGTRAP ALDOB AP2B1 CCDC114 DCTD FAM9B GPRASP2 KRT18 KRT40 MAGEA11 MAPRE2 MAPRE3 MLH1 MRFAP1L1 MTUS2 PPCDC PSME3 RABAC1 RABGEF1 RBM45 REEP6 RPIA SCYL3 SHARPIN SSNA1 STUB1 THAP1 TIFA TRIM21 TRIP6 UCHL5 VIM VPS52 ZBTB14	30 interactors: AP1G1 BLOC1S6 CIPC DAZAP2 DGCR6 GGA1 GGA2 HRAS KXD1 L1CAM MON1A MON1B RAB21 RAB33B RAB4A RABEP1 RNF11 RNF168 RPS27A TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBB UBC UBE2D1 UBE2D3 YWHAB ZC2HC1C
Entrez ID		25828	27342
HPRD ID		07161	11477
Ensembl ID		ENSG00000100348	ENSG00000243335
Uniprot IDs		B4DX69 Q99757	B4DZM7 Q9UJ41
PDB IDs		1UVZ 1W4V 1W89	1TXU 2C7M 2C7N 2OT3
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Cell Cycle Protein Ubiquitination Protein Modification By Small Protein Conjugation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Autoubiquitination Negative Regulation Of Kit Signaling Pathway Meiotic Metaphase I Plate Congression Golgi To Plasma Membrane CFTR Protein Transport Meiotic Spindle Midzone Assembly Regulation Of Proteasomal Protein Catabolic Process I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Mitotic Recombination Positive Regulation Of Microtubule Plus-end Binding Fructose Catabolic Process Embryonic Ectodermal Digestive Tract Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Viral Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Execution Phase Of Apoptosis Nucleotide Metabolic Process Positive Regulation Of Ligase Activity Negative Regulation Of Protein Deubiquitination Regulation Of CD40 Signaling Pathway Protein Linear Polyubiquitination Positive Regulation Of Cell Cycle Apoptotic Process Signaling Nicotinamide Nucleotide Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Recombination Pentose-phosphate Shunt, Non-oxidative Branch Fructose 1,6-bisphosphate Metabolic Process Male Meiosis Chromosome Segregation Positive Regulation Of Viral Entry Into Host Cell Programmed Cell Death Cell Communication Protein Complex Assembly Cell Cycle Process Regulation Of Cytokine-mediated Signaling Pathway Cell Death Nucleobase-containing Small Molecule Metabolic Process Death Negative Regulation Of Interleukin-6 Secretion Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Immune Response Intracellular Transport Of Virus Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Intracellular Transport Positive Regulation Of Innate Immune Response Establishment Of Localization In Cell Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Protein Transport Innate Immune Response DNA-templated Transcription, Initiation Cellular Response To Growth Factor Stimulus Negative Regulation Of Type I Interferon Production Viral Protein Processing Response To Growth Factor Establishment Of Protein Localization Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Immune System Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Innate Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Immune Response-regulating Signaling Pathway Cellular Localization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Immune Response Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?			abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Difference) ?			abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Intersection) ?