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SMAD2 and KHDRBS1
Number of citations of the paper that reports this interaction (PubMedID
15231748
)
54
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
SMAD2
KHDRBS1
Description
SMAD family member 2
KH RNA binding domain containing, signal transduction associated 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
SMAD Protein Complex
Homomeric SMAD Protein Complex
Heteromeric SMAD Protein Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Protein-containing Complex
Grb2-Sos Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Phosphatase Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
SMAD Binding
Metal Ion Binding
Tau Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
Nucleic Acid Binding
DNA Binding
RNA Binding
MRNA Binding
Protein Binding
Poly(A) Binding
Poly(U) RNA Binding
SH3 Domain Binding
Protein Domain Specific Binding
Signaling Adaptor Activity
SH2 Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Molecular Function Inhibitor Activity
Protein Tyrosine Kinase Binding
Biological Process
Ureteric Bud Development
In Utero Embryonic Development
Endoderm Formation
Mesoderm Formation
Regionalization
Determination Of Left/right Asymmetry In Lateral Mesoderm
Aortic Valve Morphogenesis
Pulmonary Valve Morphogenesis
Endocardial Cushion Morphogenesis
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Transforming Growth Factor Beta Receptor Signaling Pathway
Zygotic Specification Of Dorsal/ventral Axis
Gastrulation
Pattern Specification Process
Endoderm Development
Mesoderm Development
Heart Development
Cell Population Proliferation
Anatomical Structure Morphogenesis
Response To Glucose
Post-embryonic Development
Embryonic Pattern Specification
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Insulin Secretion
Cell Differentiation
Negative Regulation Of Ossification
Lung Development
Positive Regulation Of BMP Signaling Pathway
Pancreas Development
Primary MiRNA Processing
Activin Receptor Signaling Pathway
Organ Growth
Intracellular Signal Transduction
Nodal Signaling Pathway
Cell Fate Commitment
Negative Regulation Of Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Morphogenesis
Developmental Growth
Embryonic Foregut Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Multicellular Organismal Process
Pericardium Development
SMAD Protein Signal Transduction
Mesenchyme Development
Trophoblast Cell Migration
Secondary Palate Development
Response To Cholesterol
Response To Transforming Growth Factor Beta
Odontoblast Differentiation
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Alternative MRNA Splicing, Via Spliceosome
MRNA Processing
Cell Surface Receptor Signaling Pathway
Spermatogenesis
Regulation Of Protein Stability
Regulation Of Apoptotic Process
Regulation Of RNA Splicing
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Translational Initiation
Regulation Of RNA Export From Nucleus
Positive Regulation Of RNA Export From Nucleus
Regulation Of MRNA Splicing, Via Spliceosome
T Cell Receptor Signaling Pathway
Regulation Of Cell Cycle
Pathways
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Germ layer formation at gastrulation
Formation of axial mesoderm
Formation of definitive endoderm
Formation of definitive endoderm
PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Dexfosfoserine
Diseases
Colorectal cancer
GWAS
Coronary artery disease in type 1 diabetes (
29695241
)
Daytime nap (
33568662
)
Lung cancer in ever smokers (
28604730
)
Menarche (age at onset) (
27182965
)
Body mass index (
26426971
)
Interacting Genes
220 interacting genes:
ABTB1
ACVR1B
AFDN
AKT1
ANAPC10
ANAPC2
ANK3
ANP32B
ANP32E
ANTXR2
AP1B1
ARFGAP3
ARHGEF6
ARL4D
ATP5ME
AXIN1
BAZ1A
BECN1
BPTF
BRCA1
BTBD2
C22orf46P
CAMK2A
CAMK2G
CDC16
CDC27
CDC40
CDK2
CDK4
CDK8
CDK9
CISH
COPS5
CORO2A
CREBBP
CSH1
CSH2
CSNK1D
CTNNB1
CUL5
CYLC2
CYP11A1
DAB2
DCAF6
DCUN1D1
DENND2B
DNAJB5
DNAJC7
DOCK8
DVL1
DYNC1H1
DYRK1A
E2F4
EEF1A1
EID2
EIF3L
ELAC2
EP300
ERBIN
ESR1
ESR2
FAM161B
FBN2
FBP2
FHL2
FHL3
FOXG1
FOXH1
FOXO3
GATAD2B
GFER
GLI3
GRIPAP1
GSC
GTF2I
HDAC1
HDAC2
HGS
HIPK2
HNF4A
HOXA13
HOXA9
HOXD13
HSD17B3
HUWE1
HYAL2
INSR
IRAK2
ITCH
JUN
KAT2B
KHDRBS1
KPNB1
LAMA5
LATS2
LCK
LEF1
LEMD3
LHX9
LITAF
LMO2
MAP2K1
MAPK1
MAPK3
MAPK8
MAPK9
MECOM
MED15
MED6
MEF2A
MEF2C
MYC
MYOCD
NAGK
NCOA6
NEDD4L
NEDD9
NEFM
NFIA
NFYC
NOTCH4
NUAK2
NUP153
NUP214
OS9
OTUB1
PAK1
PAPOLA
PAPPA
PARD3
PAXIP1
PEX19
PIAS3
PIAS4
PIK3CA
PLIN3
POU2AF1
PPM1A
PPP2R1A
PRKAR1A
PSAP
PSG9
PSMD11
PSMD8
PTMS
RAB34
RAB38
RAN
RANBP6
RANBP9
RARB
RASA1
RASD2
RASL12
RBL1
RHEBL1
RHOA
RHOD
RHOJ
RIT1
RNF123
RNPC3
ROCK1
RPS14
RPS27A
RUNX2
RXRA
SKI
SKIL
SKOR2
SMAD1
SMAD3
SMAD4
SMAD7
SMAD9
SMURF1
SMURF2
SNAPIN
SNIP1
SNRNP70
SNW1
SOD1
SP1
SQSTM1
SRI
ST13
STAG1
STAMBP
STAMBPL1
STRAP
STUB1
SYT1
TBC1D1
TGFBR1
TGFBRAP1
TGIF1
TGM2
TNNT1
TOB1
TP53
TP73
TRIM62
TRMO
TSC2
TUBA1B
UBA52
UBR5
UCHL5
USP9X
WASHC4
XPA
YY1
ZEB1
ZEB2
ZFYVE9
ZMYND11
ZNF41
ZNF510
ZNF8
ZNHIT6
116 interacting genes:
ABI2
ACTB
AGO1
AHI1
AMPH
APBB1
ARHGEF4
ARHGEF9
AZIN1
BAIAP2L1
BTK
CBL
CD2AP
CDC42
CDK1
CEBPA
CIRBP
CLK1
CREB3L3
CREBBP
CRK
CRKL
CSK
DDX5
DHX9
DLG1
DLG2
DLG3
DLG4
DNMBP
DOCK2
DOCK3
DSCAM
EFEMP1
EMG1
FGR
FNBP4
FRK
FXR1
FXR2
FYN
GAS7
GPHN
GRAP
GRAP2
GRB2
HCK
HNRNPK
INSR
ITK
ITPRID2
ITSN1
ITSN2
JAK3
KHDRBS3
LCK
LYN
MAPK1
MYO1C
MYO7A
NCF1
NCK1
NCK2
NCKIPSD
NPHP1
OGT
OSTF1
PACSIN1
PALS2
PIK3R1
PIK3R3
PLCG1
PLCG2
POT1
PPP1R13B
PRMT1
PSTPIP1
PTBP2
PTK6
PTPN6
RALY
RAPSN
RASA1
RBFOX2
RBM7
RUSC2
SASH1
SCG5
SH3PXD2A
SH3YL1
SHANK3
SKAP2
SMAD2
SMARCA2
SNX30
SNX9
SORBS1
SPATA13
SRC
SRPK2
STAT3
STUB1
TBL1X
TJP1
TSPOAP1
TUBB3
UBA52
UBASH3B
UBC
USP7
VAV1
WBP4
YES1
YTHDC1
ZBTB7A
ZDHHC6
Entrez ID
4087
10657
HPRD ID
03221
03926
Ensembl ID
ENSG00000175387
ENSG00000121774
Uniprot IDs
B7Z5N5
Q15796
Q53XR6
Q07666
PDB IDs
1DEV
1KHX
1U7V
2LB3
5XOD
5ZOJ
6H3R
6M64
6YIA
6ZVQ
7CO1
2XA6
3QHE
7Z89
7Z8A
7Z9A
7Z9B
7ZAB
7ZAC
7ZAF
7ZAM
Enriched GO Terms of Interacting Partners
?
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleoplasm
SMAD Binding
Regulation Of Signal Transduction
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Transcription Regulator Complex
Regulation Of Primary Metabolic Process
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Communication
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Signaling
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Developmental Process
Positive Regulation Of Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Intracellular Signal Transduction
Chromatin
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Enzyme-linked Receptor Protein Signaling Pathway
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cytosol
Cytoplasm
Intracellular Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Cell-cell Junction
Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Immune Response-activating Signaling Pathway
Positive Regulation Of Cellular Component Organization
Regulation Of Cellular Component Organization
Fc Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
SH3 Domain Binding
Protein Binding
Activation Of Immune Response
Regulation Of Intracellular Signal Transduction
Antigen Receptor-mediated Signaling Pathway
Plasma Membrane
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Signal Transduction
T Cell Receptor Signaling Pathway
T Cell Costimulation
Regulation Of Endocytosis
Fc-gamma Receptor Signaling Pathway
Intracellular Signaling Cassette
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Phosphorylation
Regulation Of Transport
Protein Phosphorylation
Fc Receptor Mediated Stimulatory Signaling Pathway
Ephrin Receptor Binding
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Regulation Of Vesicle-mediated Transport
Developmental Process
Regulation Of Immune Response
Immune System Process
Ionotropic Glutamate Receptor Binding
Endocytosis
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Ephrin Receptor Signaling Pathway
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Tagcloud (Intersection)
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