SMAD2 and AXIN1

Number of citations of the paper that reports this interaction (PMID 11438668)
38

Data Source:
HPRD (in vivo)

		SMAD2	AXIN1
Gene Name		SMAD family member 2	axin 1
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Activin Responsive Factor Complex SMAD Protein Complex SMAD2-SMAD3 Protein Complex	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Microtubule Cell Cortex Postsynaptic Density Cytoplasmic Membrane-bounded Vesicle Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Transcription Factor Binding Phosphatase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Type I Transforming Growth Factor Beta Receptor Binding Enhancer Binding SMAD Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding	P53 Binding Signal Transducer Activity GTPase Activator Activity Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Enzyme Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity Ubiquitin Protein Ligase Binding Protein Complex Scaffold Identical Protein Binding Protein Homodimerization Activity Protein Self-association SMAD Binding Armadillo Repeat Domain Binding I-SMAD Binding R-SMAD Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development In Utero Embryonic Development Endoderm Formation Mesoderm Formation Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Complex Assembly Zygotic Specification Of Dorsal/ventral Axis Gastrulation Negative Regulation Of Cell Proliferation Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Lung Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Pancreas Development Primary MiRNA Processing Activin Receptor Signaling Pathway Somatic Stem Cell Maintenance Organ Growth Intracellular Signal Transduction Nodal Signaling Pathway Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Paraxial Mesoderm Morphogenesis Developmental Growth Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Binding Palate Development Pericardium Development SMAD Protein Signal Transduction Response To Cholesterol Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry	Protein Polyubiquitination In Utero Embryonic Development Optic Placode Formation Positive Regulation Of Protein Phosphorylation Nucleocytoplasmic Transport Apoptotic Process Activation Of JUN Kinase Activity Determination Of Left/right Symmetry Sensory Perception Of Sound Cell Death Dorsal/ventral Axis Specification Positive Regulation Of Peptidyl-threonine Phosphorylation Forebrain Anterior/posterior Pattern Specification Wnt-activated Signaling Pathway Involved In Forebrain Neuron Fate Commitment Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Olfactory Placode Formation Cytoplasmic Microtubule Organization Positive Regulation Of Protein Ubiquitination Activation Of Protein Kinase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Catenin Import Into Nucleus Post-anal Tail Morphogenesis Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity Cellular Protein Complex Assembly Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Embryonic Eye Morphogenesis Axial Mesoderm Formation Negative Regulation Of Protein Metabolic Process Protein Homooligomerization Positive Regulation Of Ubiquitin-protein Transferase Activity Muscle Cell Development Canonical Wnt Signaling Pathway Embryonic Skeletal Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Cellular Response To Organic Cyclic Compound Genetic Imprinting Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer	misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling degradation of AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS			Bone mineral density ( 22504420)
Protein-Protein Interactions		207 interactors: ABTB1 ACVR1B AKT1 ANAPC10 ANAPC2 ANK3 ANP32B ANP32E ANTXR2 AP1B1 ARFGAP3 ARHGEF6 ARL4D ATP5I AXIN1 BAZ1A BPTF BRCA1 BTBD2 C22orf46 CAMK2A CAMK2G CDC16 CDC27 CDC40 CDK2 CDK4 CDK8 CDK9 CISH COPS5 CREBBP CSH1 CSH2 CSNK1D CTNNB1 CUL5 CYP11A1 DAB2 DCAF6 DCUN1D1 DNAJC7 DOCK8 DVL1 DYNC1H1 E2F4 EEF1A1 EID2 EIF3L ELAC2 EP300 ERBB2IP ESR1 ESR2 FAM161B FBN2 FHL2 FHL3 FOXG1 FOXH1 FOXO3 GATAD2B GFER GLI3 GRIPAP1 GSC GTF2I HDAC1 HDAC2 HGS HIPK2 HNF4A HOXA13 HOXA9 HOXD13 HUWE1 INSR IRAK2 ITCH JUN KAT2B KHDRBS1 KIAA1033 KPNB1 LAMA5 LCK LEF1 LEMD3 LHX9 LITAF LMO2 MAPK1 MAPK3 MAPK8 MAPK9 MECOM MED15 MED6 MEF2A MEF2C MLLT4 MYC MYOCD NAGK NCOA6 NEDD4L NEDD9 NEFM NF1 NFYC NOTCH4 NUAK2 NUP153 NUP214 OS9 OTUB1 PAK1 PAPOLA PAPPA PARD3 PARD3B PAXIP1 PEX19 PIAS3 PIAS4 PIK3CA PLIN3 POU2AF1 PPM1A PPP2R1A PRKAR1A PSAP PSG9 PSMD11 PSMD8 PTMS RAB34 RAB38 RAN RANBP6 RANBP9 RARB RASD2 RASL12 RBL1 RHEBL1 RHOA RHOD RHOJ RIT1 RNF123 RNPC3 ROCK1 RPS14 RPS27A RUNX2 RXRA SKI SKIL SKOR2 SMAD1 SMAD3 SMAD4 SMAD7 SMAD9 SMURF1 SMURF2 SNAPIN SNIP1 SNRNP70 SNW1 SOD1 SP1 SQSTM1 SRI ST13 ST5 STAG1 STAMBP STAMBPL1 STRAP STUB1 SYT1 TBC1D1 TGFBR1 TGFBRAP1 TGIF1 TGM2 TNNT1 TOB1 TP53 TP73 TRIM62 TSC2 TUBA1B UBA52 UBR5 UCHL5 USP9X YY1 ZEB1 ZEB2 ZFYVE9 ZMYND11 ZNF41 ZNF8 ZNHIT6	43 interactors: AMER1 ANP32A APC BTRC CARM1 CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 GAK GNAS GSK3B JUP LMO2 LRP5 LRP6 MAP3K4 MYC MYOT NCK2 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 RNF111 RUNX2 SENP2 SH3GL1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 UTP14A
Entrez ID		4087	8312
HPRD ID		03221	04819
Ensembl ID		ENSG00000175387	ENSG00000103126
Uniprot IDs		B7Z5N5 Q15796 Q53XR6	O15169
PDB IDs		1DEV 1KHX 1U7V 2LB3	1DK8 1EMU 1O9U 3ZDI 4B7T
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Gene Expression Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Cell Communication Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Signaling Cellular Response To Stimulus Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Cellular Response To Growth Factor Stimulus Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Wnt Signaling Pathway Regulation Of Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Signaling Cell Communication Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Signaling Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Regulation Of Gene Expression Canonical Wnt Signaling Pathway Response To Growth Factor Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Tissue Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Positive Regulation Of Metabolic Process Organ Morphogenesis Anatomical Structure Development System Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Developmental Process Organ Development Multicellular Organismal Development Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus
Tagcloud ?		adenoviral cbp coactivators e1a enhancement fashion interacted interacting intrinsic lux mapped mediating minimal oncoprotein p300 p3tp possess possibility raise regulators rest signalling smad3 smads superfamily tgf transactivation transforming	aberrations applying arid2 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently rps6ka3 seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs
Tagcloud (Difference) ?		adenoviral cbp coactivators e1a enhancement fashion interacted interacting intrinsic lux mapped mediating minimal oncoprotein p300 p3tp possess possibility raise regulators rest signalling smad3 smads superfamily tgf transactivation transforming	aberrations applying arid2 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently rps6ka3 seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs
Tagcloud (Intersection) ?