SMAD2 and LEMD3

Number of citations of the paper that reports this interaction (PMID 15489854)
47

Data Source:
HPRD (two hybrid)

		SMAD2	LEMD3
Gene Name		SMAD family member 2	LEM domain containing 3
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Activin Responsive Factor Complex SMAD Protein Complex SMAD2-SMAD3 Protein Complex	Nuclear Inner Membrane Integral Component Of Nuclear Inner Membrane Membrane Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Transcription Factor Binding Phosphatase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Type I Transforming Growth Factor Beta Receptor Binding Enhancer Binding SMAD Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding	Nucleotide Binding DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development In Utero Embryonic Development Endoderm Formation Mesoderm Formation Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Complex Assembly Zygotic Specification Of Dorsal/ventral Axis Gastrulation Negative Regulation Of Cell Proliferation Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Lung Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Pancreas Development Primary MiRNA Processing Activin Receptor Signaling Pathway Somatic Stem Cell Maintenance Organ Growth Intracellular Signal Transduction Nodal Signaling Pathway Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Paraxial Mesoderm Morphogenesis Developmental Growth Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Binding Palate Development Pericardium Development SMAD Protein Signal Transduction Response To Cholesterol Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry	Blood Vessel Endothelial Cell Migration Involved In Intussusceptive Angiogenesis Nucleus Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Skeletal Muscle Cell Differentiation Regulation Of Cell Cycle Regulation Of Extracellular Matrix Organization
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer	Mitotic Prophase Nuclear Envelope Breakdown Depolymerisation of the Nuclear Lamina Nuclear Envelope Reassembly Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase Initiation of Nuclear Envelope Reformation Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		207 interactors: ABTB1 ACVR1B AKT1 ANAPC10 ANAPC2 ANK3 ANP32B ANP32E ANTXR2 AP1B1 ARFGAP3 ARHGEF6 ARL4D ATP5I AXIN1 BAZ1A BPTF BRCA1 BTBD2 C22orf46 CAMK2A CAMK2G CDC16 CDC27 CDC40 CDK2 CDK4 CDK8 CDK9 CISH COPS5 CREBBP CSH1 CSH2 CSNK1D CTNNB1 CUL5 CYP11A1 DAB2 DCAF6 DCUN1D1 DNAJC7 DOCK8 DVL1 DYNC1H1 E2F4 EEF1A1 EID2 EIF3L ELAC2 EP300 ERBB2IP ESR1 ESR2 FAM161B FBN2 FHL2 FHL3 FOXG1 FOXH1 FOXO3 GATAD2B GFER GLI3 GRIPAP1 GSC GTF2I HDAC1 HDAC2 HGS HIPK2 HNF4A HOXA13 HOXA9 HOXD13 HUWE1 INSR IRAK2 ITCH JUN KAT2B KHDRBS1 KIAA1033 KPNB1 LAMA5 LCK LEF1 LEMD3 LHX9 LITAF LMO2 MAPK1 MAPK3 MAPK8 MAPK9 MECOM MED15 MED6 MEF2A MEF2C MLLT4 MYC MYOCD NAGK NCOA6 NEDD4L NEDD9 NEFM NF1 NFYC NOTCH4 NUAK2 NUP153 NUP214 OS9 OTUB1 PAK1 PAPOLA PAPPA PARD3 PARD3B PAXIP1 PEX19 PIAS3 PIAS4 PIK3CA PLIN3 POU2AF1 PPM1A PPP2R1A PRKAR1A PSAP PSG9 PSMD11 PSMD8 PTMS RAB34 RAB38 RAN RANBP6 RANBP9 RARB RASD2 RASL12 RBL1 RHEBL1 RHOA RHOD RHOJ RIT1 RNF123 RNPC3 ROCK1 RPS14 RPS27A RUNX2 RXRA SKI SKIL SKOR2 SMAD1 SMAD3 SMAD4 SMAD7 SMAD9 SMURF1 SMURF2 SNAPIN SNIP1 SNRNP70 SNW1 SOD1 SP1 SQSTM1 SRI ST13 ST5 STAG1 STAMBP STAMBPL1 STRAP STUB1 SYT1 TBC1D1 TGFBR1 TGFBRAP1 TGIF1 TGM2 TNNT1 TOB1 TP53 TP73 TRIM62 TSC2 TUBA1B UBA52 UBR5 UCHL5 USP9X YY1 ZEB1 ZEB2 ZFYVE9 ZMYND11 ZNF41 ZNF8 ZNHIT6	4 interactors: BCLAF1 SMAD1 SMAD2 SMAD9
Entrez ID		4087	23592
HPRD ID		03221	09704
Ensembl ID		ENSG00000175387	ENSG00000174106
Uniprot IDs		B7Z5N5 Q15796 Q53XR6	Q9Y2U8
PDB IDs		1DEV 1KHX 1U7V 2LB3	2CH0
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Gene Expression Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Cell Communication Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Signaling Cellular Response To Stimulus Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Cellular Response To Growth Factor Stimulus Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Primary MiRNA Processing Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Epithelium Development SMAD Protein Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Production Of MiRNAs Involved In Gene Silencing By MiRNA Kidney Development Renal System Development Positive Regulation Of Transcription, DNA-templated Gene Silencing By MiRNA Cellular Response To DsRNA Urogenital System Development Posttranscriptional Gene Silencing Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Silencing By RNA Skeletal System Development Cellular Response To Growth Factor Stimulus Response To DsRNA BMP Signaling Pathway Response To Growth Factor Mesoderm Formation Midbrain Development Embryonic Pattern Specification Mesoderm Morphogenesis Organ Growth Transcription, DNA-templated Tube Development RNA Biosynthetic Process Gene Silencing Positive Regulation Of Cellular Metabolic Process Formation Of Primary Germ Layer Positive Regulation Of Cell Differentiation Mesoderm Development Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Hindbrain Development Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry RNA Metabolic Process Gastrulation Epithelium Development
Tagcloud ?		adenoviral cbp coactivators e1a enhancement fashion interacted interacting intrinsic lux mapped mediating minimal oncoprotein p300 p3tp possess possibility raise regulators rest signalling smad3 smads superfamily tgf transactivation transforming	12q13 12q14 3q14 3q15 atrial autism bands centres comprising delay deleted deletions ductus dysmorphism encompassing ended extends facial hmga2 microdeletions osteopoikilosis overlapping overlaps patent septal speech stature stenosis subtle
Tagcloud (Difference) ?		adenoviral cbp coactivators e1a enhancement fashion interacted interacting intrinsic lux mapped mediating minimal oncoprotein p300 p3tp possess possibility raise regulators rest signalling smad3 smads superfamily tgf transactivation transforming	12q13 12q14 3q14 3q15 atrial autism bands centres comprising delay deleted deletions ductus dysmorphism encompassing ended extends facial hmga2 microdeletions osteopoikilosis overlapping overlaps patent septal speech stature stenosis subtle
Tagcloud (Intersection) ?