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SMAD2 and MYC
Number of citations of the paper that reports this interaction (PubMedID
28205554
)
55
Data Source:
BioGRID
(fluorescent resonance energy transfer)
HPRD
(in vivo, in vitro, two hybrid)
SMAD2
MYC
Description
SMAD family member 2
MYC proto-oncogene, bHLH transcription factor
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
SMAD Protein Complex
Homomeric SMAD Protein Complex
Heteromeric SMAD Protein Complex
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Spindle
Nuclear Body
Axon
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Myc-Max Complex
RNA Polymerase II Transcription Repressor Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Phosphatase Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
SMAD Binding
Metal Ion Binding
Tau Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
Core Promoter Sequence-specific DNA Binding
Transcription Coregulator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein-containing Complex Binding
Protein Dimerization Activity
E-box Binding
DNA-binding Transcription Factor Binding
SCF Ubiquitin Ligase Complex Binding
Biological Process
Ureteric Bud Development
In Utero Embryonic Development
Endoderm Formation
Mesoderm Formation
Regionalization
Determination Of Left/right Asymmetry In Lateral Mesoderm
Aortic Valve Morphogenesis
Pulmonary Valve Morphogenesis
Endocardial Cushion Morphogenesis
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Transforming Growth Factor Beta Receptor Signaling Pathway
Zygotic Specification Of Dorsal/ventral Axis
Gastrulation
Pattern Specification Process
Endoderm Development
Mesoderm Development
Heart Development
Cell Population Proliferation
Anatomical Structure Morphogenesis
Response To Glucose
Post-embryonic Development
Embryonic Pattern Specification
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Insulin Secretion
Cell Differentiation
Negative Regulation Of Ossification
Lung Development
Positive Regulation Of BMP Signaling Pathway
Pancreas Development
Primary MiRNA Processing
Activin Receptor Signaling Pathway
Organ Growth
Intracellular Signal Transduction
Nodal Signaling Pathway
Cell Fate Commitment
Negative Regulation Of Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Morphogenesis
Developmental Growth
Embryonic Foregut Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Multicellular Organismal Process
Pericardium Development
SMAD Protein Signal Transduction
Mesenchyme Development
Trophoblast Cell Migration
Secondary Palate Development
Response To Cholesterol
Response To Transforming Growth Factor Beta
Odontoblast Differentiation
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Branching Involved In Ureteric Bud Morphogenesis
B Cell Apoptotic Process
NK T Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of B Cell Apoptotic Process
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
DNA Damage Response
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Radiation
Response To Xenobiotic Stimulus
Regulation Of Gene Expression
Regulation Of Cell Cycle Process
Positive Regulation Of Gene Expression
Myotube Differentiation
Wnt Signaling Pathway
RRNA Metabolic Process
Protein Processing
Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Stress-activated MAPK Cascade
Protein-DNA Complex Disassembly
Cellular Response To UV
Cellular Response To Interferon-alpha
Skeletal Muscle Cell Differentiation
Middle Ear Morphogenesis
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Response To Alkaloid
Pigmentation
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Fibroblast Apoptotic Process
Negative Regulation Of Monocyte Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
Negative Regulation Of Fibroblast Proliferation
Skeletal System Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Chromosome Organization
Negative Regulation Of Cell Division
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Negative Regulation Of Transcription Initiation By RNA Polymerase II
ERK1 And ERK2 Cascade
Response To Growth Factor
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of MiRNA Transcription
Regulation Of Somatic Stem Cell Population Maintenance
Positive Regulation Of Acinar Cell Proliferation
Acinar Cell Proliferation
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Germ layer formation at gastrulation
Formation of axial mesoderm
Formation of definitive endoderm
Formation of definitive endoderm
Transcription of E2F targets under negative control by DREAM complex
Signaling by ALK
NOTCH1 Intracellular Domain Regulates Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Binding of TCF/LEF:CTNNB1 to target gene promoters
MAPK6/MAPK4 signaling
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
TFAP2 (AP-2) family regulates transcription of cell cycle factors
RUNX3 regulates WNT signaling
Estrogen-dependent gene expression
Transcriptional regulation of granulopoiesis
Regulation of CDH1 mRNA translation by microRNAs
Regulation of NFE2L2 gene expression
Regulation of PD-L1(CD274) transcription
Drugs
Dexfosfoserine
Acetylsalicylic acid
Dimethyl sulfoxide
Doconexent
Nadroparin
Diseases
Colorectal cancer
Penile cancer
Breast cancer
Laryngeal cancer
Oral cancer
Multiple myeloma
Kaposi's sarcoma
Ovarian cancer
Choriocarcinoma
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
Burkitt lymphoma
Small cell lung cancer
Osteosarcoma
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
Coronary artery disease in type 1 diabetes (
29695241
)
Daytime nap (
33568662
)
Lung cancer in ever smokers (
28604730
)
Menarche (age at onset) (
27182965
)
Alcohol use disorder (
30940813
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
30013184
)
Allergic sensitization (
23817571
)
Asthma (
34103634
32296059
30929738
)
Asthma (childhood onset) (
31036433
30929738
)
Bladder cancer (
20972438
)
Breast cancer (
29059683
23535729
)
Chronic lymphocytic leukemia (
23770605
)
Colorectal cancer (
24737748
25990418
26151821
23266556
)
Colorectal cancer or advanced adenoma (
30510241
)
Diffuse large B cell lymphoma (
25261932
)
Endometrial cancer (
30093612
27135401
)
Endometrial cancer (endometrioid histology) (
30093612
)
Endometrial endometrioid carcinoma (
27135401
)
Glioblastoma (
29743610
)
Glioma (
29743610
)
Height (
25429064
)
Multiple sclerosis (
21833088
)
Non-glioblastoma glioma (
29743610
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Ovarian cancer (
20852632
23535730
)
Pancreatic cancer (
27579533
29422604
25086665
)
Prostate cancer (
24753544
)
Prostate cancer (early onset) (
24740154
)
Prostate-specific antigen levels (
28139693
)
Prostate-specific antigen levels (conditioned on lead SNPs) (
28139693
)
Renal cell carcinoma (
24220699
)
Serum alkaline phosphatase levels (
33547301
)
Urinary bladder cancer (
24861552
18794855
20348956
)
Interacting Genes
220 interacting genes:
ABTB1
ACVR1B
AFDN
AKT1
ANAPC10
ANAPC2
ANK3
ANP32B
ANP32E
ANTXR2
AP1B1
ARFGAP3
ARHGEF6
ARL4D
ATP5ME
AXIN1
BAZ1A
BECN1
BPTF
BRCA1
BTBD2
C22orf46P
CAMK2A
CAMK2G
CDC16
CDC27
CDC40
CDK2
CDK4
CDK8
CDK9
CISH
COPS5
CORO2A
CREBBP
CSH1
CSH2
CSNK1D
CTNNB1
CUL5
CYLC2
CYP11A1
DAB2
DCAF6
DCUN1D1
DENND2B
DNAJB5
DNAJC7
DOCK8
DVL1
DYNC1H1
DYRK1A
E2F4
EEF1A1
EID2
EIF3L
ELAC2
EP300
ERBIN
ESR1
ESR2
FAM161B
FBN2
FBP2
FHL2
FHL3
FOXG1
FOXH1
FOXO3
GATAD2B
GFER
GLI3
GRIPAP1
GSC
GTF2I
HDAC1
HDAC2
HGS
HIPK2
HNF4A
HOXA13
HOXA9
HOXD13
HSD17B3
HUWE1
HYAL2
INSR
IRAK2
ITCH
JUN
KAT2B
KHDRBS1
KPNB1
LAMA5
LATS2
LCK
LEF1
LEMD3
LHX9
LITAF
LMO2
MAP2K1
MAPK1
MAPK3
MAPK8
MAPK9
MECOM
MED15
MED6
MEF2A
MEF2C
MYC
MYOCD
NAGK
NCOA6
NEDD4L
NEDD9
NEFM
NFIA
NFYC
NOTCH4
NUAK2
NUP153
NUP214
OS9
OTUB1
PAK1
PAPOLA
PAPPA
PARD3
PAXIP1
PEX19
PIAS3
PIAS4
PIK3CA
PLIN3
POU2AF1
PPM1A
PPP2R1A
PRKAR1A
PSAP
PSG9
PSMD11
PSMD8
PTMS
RAB34
RAB38
RAN
RANBP6
RANBP9
RARB
RASA1
RASD2
RASL12
RBL1
RHEBL1
RHOA
RHOD
RHOJ
RIT1
RNF123
RNPC3
ROCK1
RPS14
RPS27A
RUNX2
RXRA
SKI
SKIL
SKOR2
SMAD1
SMAD3
SMAD4
SMAD7
SMAD9
SMURF1
SMURF2
SNAPIN
SNIP1
SNRNP70
SNW1
SOD1
SP1
SQSTM1
SRI
ST13
STAG1
STAMBP
STAMBPL1
STRAP
STUB1
SYT1
TBC1D1
TGFBR1
TGFBRAP1
TGIF1
TGM2
TNNT1
TOB1
TP53
TP73
TRIM62
TRMO
TSC2
TUBA1B
UBA52
UBR5
UCHL5
USP9X
WASHC4
XPA
YY1
ZEB1
ZEB2
ZFYVE9
ZMYND11
ZNF41
ZNF510
ZNF8
ZNHIT6
182 interacting genes:
ACTL6A
AKT1
APP
ARAF
ARNT
ATAD2
ATG5
AURKA
AXIN1
BCL2
BIN1
BRCA1
BRD3
CBLC
CCAR2
CCNE1
CCNT1
CDC6
CDC73
CDCA7L
CDK1
CDK6
CDK8
CDKN1B
CDKN2A
CDKN2B
CDKN2C
CEBPA
CEBPB
CEP57
CHD8
CHUK
CIP2A
CREBBP
CSNK2A1
CSNK2A2
DACH1
DNMT3A
EFNB1
ELF3
ELP3
EP300
EP400
EPHA2
ERBB2
FBXO32
FBXO8
FBXW7
FBXW8
FGFR4
FZR1
GCN1
GLIS1
GLIS2
GPX2
GRM1
GSK3A
GSK3B
GTF2F1
GTF2I
HIF1A
HNRNPD
HSP90AA1
IKBKB
ING4
KAT2A
KAT2B
KAT5
KDELR2
KDM1A
KIDINS220
LATS2
LDOC1
MAP2K1
MAP2K5
MAPK1
MAPK14
MAPK3
MAPK7
MAPK8
MAX
MDM2
MED1
MED16
MEN1
MET
MLH1
MOK
MXD1
MXI1
MYCBP
MYCBP2
NDRG1
NEK11
NF2
NFIC
NFYB
NFYC
NMI
NONO
NOTCH3
NUCB1
OTUB1
PAK2
PARP10
PCGF6
PDGFRA
PFDN5
PIK3CA
PLAU
PLK1
PML
PPP2CA
PPP3R1
PRDX1
PSMC3
PTEN
RAF1
RASSF1
RB1
RBL1
RELA
RIOX2
SAP130
SENP2
SF3B1
SKP1
SKP2
SMAD2
SMAD3
SMARCA2
SMARCA4
SMARCB1
SMARCC1
SNIP1
SNRNP70
SOX3
SOX4
SP1
SPAG9
STK11
SUPT3H
TADA2A
TAF12
TAF1B
TAF9
TBP
TEAD2
TERT
TFAP2A
TFAP2B
TIAM1
TONSL
TP53
TP73
TRIB3
TRIM6
TRIM63
TRIP12
TRRAP
TSC1
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
UBB
UBE3B
UBR5
USP1
USP2
USP36
USP37
USP45
USP7
VDR
WT1
YAF2
YBX1
YY1
ZBTB17
ZNF281
Entrez ID
4087
4609
HPRD ID
03221
01818
Ensembl ID
ENSG00000175387
ENSG00000136997
Uniprot IDs
B7Z5N5
Q15796
Q53XR6
P01106
PDB IDs
1DEV
1KHX
1U7V
2LB3
5XOD
5ZOJ
6H3R
6M64
6YIA
6ZVQ
7CO1
1A93
1EE4
1MV0
1NKP
2A93
2OR9
4Y7R
5I4Z
5I50
6C4U
6E16
6E24
6G6J
6G6K
6G6L
7T1Y
7T1Z
8J2Q
8OTS
8OTT
8Q1N
8WLG
8X8S
8X8V
Enriched GO Terms of Interacting Partners
?
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleoplasm
SMAD Binding
Regulation Of Signal Transduction
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Transcription Regulator Complex
Regulation Of Primary Metabolic Process
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Communication
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Signaling
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Developmental Process
Positive Regulation Of Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Intracellular Signal Transduction
Chromatin
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Enzyme-linked Receptor Protein Signaling Pathway
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Nucleoplasm
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cell Population Proliferation
Cellular Response To Stress
Regulation Of Cellular Response To Stress
Regulation Of DNA Metabolic Process
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Regulation Of Apoptotic Process
DNA-binding Transcription Factor Binding
Regulation Of Signal Transduction
Negative Regulation Of Transcription By RNA Polymerase II
Intracellular Signal Transduction
Regulation Of Developmental Process
Regulation Of Cell Differentiation
Chromatin Organization
Regulation Of Cell Cycle Phase Transition
Regulation Of Protein Stability
Protein Modification Process
Regulation Of Protein Modification Process
Chromatin Binding
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Tagcloud (Intersection)
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