SMAD2 and ERBIN

Number of citations of the paper that reports this interaction (PubMedID 12650946)
0

Data Source:
HPRD (in vitro)

		SMAD2	ERBIN
Description		SMAD family member 2	erbb2 interacting protein
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Activin Responsive Factor Complex Protein-containing Complex SMAD Protein Complex Homomeric SMAD Protein Complex Heteromeric SMAD Protein Complex	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Neuromuscular Junction Nuclear Membrane Anchoring Junction Postsynapse Glutamatergic Synapse Postsynaptic Specialization
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding SMAD Binding Metal Ion Binding Tau Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Disordered Domain Specific Binding DNA-binding Transcription Factor Binding	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Ureteric Bud Development In Utero Embryonic Development Endoderm Formation Mesoderm Formation Regionalization Determination Of Left/right Asymmetry In Lateral Mesoderm Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis DNA-templated Transcription Regulation Of DNA-templated Transcription Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Gastrulation Pattern Specification Process Endoderm Development Mesoderm Development Heart Development Cell Population Proliferation Anatomical Structure Morphogenesis Response To Glucose Post-embryonic Development Embryonic Pattern Specification Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Secretion Cell Differentiation Negative Regulation Of Ossification Lung Development Positive Regulation Of BMP Signaling Pathway Pancreas Development Primary MiRNA Processing Activin Receptor Signaling Pathway Organ Growth Intracellular Signal Transduction Nodal Signaling Pathway Cell Fate Commitment Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Morphogenesis Developmental Growth Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Multicellular Organismal Process Pericardium Development SMAD Protein Signal Transduction Mesenchyme Development Trophoblast Cell Migration Secondary Palate Development Response To Cholesterol Response To Transforming Growth Factor Beta Odontoblast Differentiation	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide Intracellular Signal Transduction Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Germ layer formation at gastrulation Formation of axial mesoderm Formation of definitive endoderm Formation of definitive endoderm	Signaling by ERBB2 Downregulation of ERBB2 signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs		Dexfosfoserine
Diseases		Colorectal cancer
GWAS		Coronary artery disease in type 1 diabetes ( 29695241) Daytime nap ( 33568662) Lung cancer in ever smokers ( 28604730) Menarche (age at onset) ( 27182965)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		220 interacting genes: ABTB1 ACVR1B AFDN AKT1 ANAPC10 ANAPC2 ANK3 ANP32B ANP32E ANTXR2 AP1B1 ARFGAP3 ARHGEF6 ARL4D ATP5ME AXIN1 BAZ1A BECN1 BPTF BRCA1 BTBD2 C22orf46P CAMK2A CAMK2G CDC16 CDC27 CDC40 CDK2 CDK4 CDK8 CDK9 CISH COPS5 CORO2A CREBBP CSH1 CSH2 CSNK1D CTNNB1 CUL5 CYLC2 CYP11A1 DAB2 DCAF6 DCUN1D1 DENND2B DNAJB5 DNAJC7 DOCK8 DVL1 DYNC1H1 DYRK1A E2F4 EEF1A1 EID2 EIF3L ELAC2 EP300 ERBIN ESR1 ESR2 FAM161B FBN2 FBP2 FHL2 FHL3 FOXG1 FOXH1 FOXO3 GATAD2B GFER GLI3 GRIPAP1 GSC GTF2I HDAC1 HDAC2 HGS HIPK2 HNF4A HOXA13 HOXA9 HOXD13 HSD17B3 HUWE1 HYAL2 INSR IRAK2 ITCH JUN KAT2B KHDRBS1 KPNB1 LAMA5 LATS2 LCK LEF1 LEMD3 LHX9 LITAF LMO2 MAP2K1 MAPK1 MAPK3 MAPK8 MAPK9 MECOM MED15 MED6 MEF2A MEF2C MYC MYOCD NAGK NCOA6 NEDD4L NEDD9 NEFM NFIA NFYC NOTCH4 NUAK2 NUP153 NUP214 OS9 OTUB1 PAK1 PAPOLA PAPPA PARD3 PAXIP1 PEX19 PIAS3 PIAS4 PIK3CA PLIN3 POU2AF1 PPM1A PPP2R1A PRKAR1A PSAP PSG9 PSMD11 PSMD8 PTMS RAB34 RAB38 RAN RANBP6 RANBP9 RARB RASA1 RASD2 RASL12 RBL1 RHEBL1 RHOA RHOD RHOJ RIT1 RNF123 RNPC3 ROCK1 RPS14 RPS27A RUNX2 RXRA SKI SKIL SKOR2 SMAD1 SMAD3 SMAD4 SMAD7 SMAD9 SMURF1 SMURF2 SNAPIN SNIP1 SNRNP70 SNW1 SOD1 SP1 SQSTM1 SRI ST13 STAG1 STAMBP STAMBPL1 STRAP STUB1 SYT1 TBC1D1 TGFBR1 TGFBRAP1 TGIF1 TGM2 TNNT1 TOB1 TP53 TP73 TRIM62 TRMO TSC2 TUBA1B UBA52 UBR5 UCHL5 USP9X WASHC4 XPA YY1 ZEB1 ZEB2 ZFYVE9 ZMYND11 ZNF41 ZNF510 ZNF8 ZNHIT6	66 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9
Entrez ID		4087	55914
HPRD ID		03221	06090
Ensembl ID		ENSG00000175387	ENSG00000112851
Uniprot IDs		B7Z5N5 Q15796 Q53XR6	A0A8V8TML4 A0A8V8TPC7 Q96RT1
PDB IDs		1DEV 1KHX 1U7V 2LB3 5XOD 5ZOJ 6H3R 6M64 6YIA 6ZVQ 7CO1	1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBH 7LUL
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Nucleoplasm SMAD Binding Regulation Of Signal Transduction Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signaling Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Transcription Regulator Complex Regulation Of Primary Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Communication Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Signaling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Developmental Process Positive Regulation Of Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Intracellular Signal Transduction Chromatin Negative Regulation Of Signaling Negative Regulation Of Cell Communication Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process	Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Heteromeric SMAD Protein Complex Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Basolateral Plasma Membrane Cell Junction Organization Adherens Junction Trophoblast Cell Migration SMAD Protein Complex Regulation Of Signal Transduction Regulation Of System Process Gastrulation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Protein Signal Transduction Embryonic Foregut Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anchoring Junction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Cell Junction Assembly Cell Junction Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Protein Kinase Binding Positive Regulation Of RNA Metabolic Process MAPK Cascade Cell-substrate Junction Assembly Response To Growth Factor Metal Ion Transport Transcription Regulator Complex Gastrulation With Mouth Forming Second Cell-substrate Junction Organization Positive Regulation Of Developmental Process Negative Regulation Of Developmental Process Negative Regulation Of Ossification Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Cell Projection Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation
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