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SMAD2 and MEF2C
Number of citations of the paper that reports this interaction (PubMedID
11160896
)
93
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
SMAD2
MEF2C
Description
SMAD family member 2
myocyte enhancer factor 2C
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
SMAD Protein Complex
Homomeric SMAD Protein Complex
Heteromeric SMAD Protein Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Sarcoplasm
Nuclear Speck
Protein-containing Complex
Postsynapse
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Phosphatase Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
SMAD Binding
Metal Ion Binding
Tau Protein Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Minor Groove Of Adenine-thymine-rich DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Histone Deacetylase Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Ureteric Bud Development
In Utero Embryonic Development
Endoderm Formation
Mesoderm Formation
Regionalization
Determination Of Left/right Asymmetry In Lateral Mesoderm
Aortic Valve Morphogenesis
Pulmonary Valve Morphogenesis
Endocardial Cushion Morphogenesis
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Transforming Growth Factor Beta Receptor Signaling Pathway
Zygotic Specification Of Dorsal/ventral Axis
Gastrulation
Pattern Specification Process
Endoderm Development
Mesoderm Development
Heart Development
Cell Population Proliferation
Anatomical Structure Morphogenesis
Response To Glucose
Post-embryonic Development
Embryonic Pattern Specification
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Insulin Secretion
Cell Differentiation
Negative Regulation Of Ossification
Lung Development
Positive Regulation Of BMP Signaling Pathway
Pancreas Development
Primary MiRNA Processing
Activin Receptor Signaling Pathway
Organ Growth
Intracellular Signal Transduction
Nodal Signaling Pathway
Cell Fate Commitment
Negative Regulation Of Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Morphogenesis
Developmental Growth
Embryonic Foregut Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Multicellular Organismal Process
Pericardium Development
SMAD Protein Signal Transduction
Mesenchyme Development
Trophoblast Cell Migration
Secondary Palate Development
Response To Cholesterol
Response To Transforming Growth Factor Beta
Odontoblast Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Blood Vessel Development
Osteoblast Differentiation
Neuron Migration
B Cell Homeostasis
Heart Looping
Endochondral Ossification
Blood Vessel Remodeling
Chondrocyte Differentiation
Germinal Center Formation
Regulation Of Germinal Center Formation
Response To Ischemia
Primary Heart Field Specification
Secondary Heart Field Specification
Outflow Tract Morphogenesis
Sinoatrial Valve Morphogenesis
Cardiac Ventricle Formation
Regulation Of DNA-templated Transcription
Apoptotic Process
Humoral Immune Response
Nervous System Development
Heart Development
Muscle Organ Development
Skeletal Muscle Tissue Development
Muscle Cell Fate Determination
Learning Or Memory
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Neural Crest Cell Differentiation
Myotube Differentiation
Cell Differentiation
Neuron Differentiation
Platelet Formation
Negative Regulation Of Ossification
Melanocyte Differentiation
Positive Regulation Of Bone Mineralization
Positive Regulation Of B Cell Proliferation
Cellular Response To Trichostatin A
B Cell Proliferation
Positive Regulation Of MAPK Cascade
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Neurotransmitter Secretion
Regulation Of Synaptic Plasticity
Positive Regulation Of Skeletal Muscle Tissue Development
Neuron Development
Cell Morphogenesis Involved In Neuron Differentiation
B Cell Receptor Signaling Pathway
Smooth Muscle Cell Differentiation
Regulation Of Synapse Assembly
Regulation Of Synaptic Transmission, Glutamatergic
Ventricular Cardiac Muscle Cell Differentiation
Regulation Of Synaptic Activity
Positive Regulation Of Cardiac Muscle Cell Proliferation
Excitatory Postsynaptic Potential
Regulation Of Dendritic Spine Development
Renal Tubule Morphogenesis
Cellular Response To Lipopolysaccharide
Cellular Response To Calcium Ion
Cellular Response To Parathyroid Hormone Stimulus
Cellular Response To Xenobiotic Stimulus
Cellular Response To Fluid Shear Stress
Cellular Response To Transforming Growth Factor Beta Stimulus
Glomerulus Morphogenesis
Nephron Tubule Epithelial Cell Differentiation
NMDA Selective Glutamate Receptor Signaling Pathway
AMPA Selective Glutamate Receptor Signaling Pathway
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Cardiac Muscle Cell Differentiation
Positive Regulation Of Behavioral Fear Response
Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis
Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Signaling by Activin
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Germ layer formation at gastrulation
Formation of axial mesoderm
Formation of definitive endoderm
Formation of definitive endoderm
ERK/MAPK targets
Transcriptional activation of mitochondrial biogenesis
Myogenesis
MECP2 regulates transcription factors
Heme signaling
Cardiogenesis
Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs
Dexfosfoserine
Diseases
Colorectal cancer
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS
Coronary artery disease in type 1 diabetes (
29695241
)
Daytime nap (
33568662
)
Lung cancer in ever smokers (
28604730
)
Menarche (age at onset) (
27182965
)
Accelerometer-based physical activity measurement (average acceleration) (
29899525
)
Adult body size (
32376654
)
Alcohol consumption (
31358974
)
Alcohol consumption (drinks per week) (
30643258
)
Alzheimer's disease (
31473137
)
Alzheimer's disease (late onset) (
24162737
)
Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) (
31835028
)
Attention deficit hyperactivity disorder (
29325848
)
Bipolar disorder lithium response (categorical) or schizophrenia (
29121268
)
Body mass index (
26426971
)
Bone mineral density (
23572186
24249740
21533022
)
Bone mineral density (hip) (
19801982
)
Bone mineral density (total hip) (
29883787
)
Bone mineral density (Ward's triangle area) (
27397699
)
Caffeine consumption from coffee (
33287642
)
Chronotype (
30696823
)
Cognitive ability (
29186694
)
Cognitive ability (MTAG) (
29186694
)
Depression (
29700475
)
Femoral neck bone mineral density (
32239398
29499414
22504420
)
Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass (
32239398
)
General cognitive ability (
29844566
)
Glomerular filtration rate in chronic kidney disease (
26420894
)
Height (
20881960
25282103
25429064
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Household income (MTAG) (
31844048
)
Intelligence (
28530673
)
Intelligence (MTAG) (
29326435
)
Lamb consumption (
32066663
)
Lymphocyte percentage of white cells (
32888494
)
Major depressive disorder (
27479909
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean platelet volume (
27863252
22139419
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Morning person (
30696823
)
Multiple sclerosis (
31604244
)
Number of sexual partners (
30643258
)
Photic sneeze reflex (
27182965
)
Platelet count (
32888494
27863252
22139419
)
Platelet distribution width (
27863252
32888494
)
Plateletcrit (
27863252
32888494
)
Red blood cell count (
27863252
32888494
)
Refractive error (
32231278
)
Regular attendance at a religious group (
29970889
)
Retinal arteriolar caliber (
23776548
)
Retinal vascular caliber (
21060863
)
Rosacea symptom severity (
29771307
)
Schizophrenia (
25056061
30285260
)
Serum alkaline phosphatase levels (
33547301
)
Smoking status (ever vs never smokers) (
30643258
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Tonometry (
17903302
)
Vascular endothelial growth factor levels (
26910538
)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) (
28448500
)
Waist circumference adjusted for BMI in active individuals (
28448500
)
Waist circumference adjusted for body mass index (
28448500
)
Interacting Genes
220 interacting genes:
ABTB1
ACVR1B
AFDN
AKT1
ANAPC10
ANAPC2
ANK3
ANP32B
ANP32E
ANTXR2
AP1B1
ARFGAP3
ARHGEF6
ARL4D
ATP5ME
AXIN1
BAZ1A
BECN1
BPTF
BRCA1
BTBD2
C22orf46P
CAMK2A
CAMK2G
CDC16
CDC27
CDC40
CDK2
CDK4
CDK8
CDK9
CISH
COPS5
CORO2A
CREBBP
CSH1
CSH2
CSNK1D
CTNNB1
CUL5
CYLC2
CYP11A1
DAB2
DCAF6
DCUN1D1
DENND2B
DNAJB5
DNAJC7
DOCK8
DVL1
DYNC1H1
DYRK1A
E2F4
EEF1A1
EID2
EIF3L
ELAC2
EP300
ERBIN
ESR1
ESR2
FAM161B
FBN2
FBP2
FHL2
FHL3
FOXG1
FOXH1
FOXO3
GATAD2B
GFER
GLI3
GRIPAP1
GSC
GTF2I
HDAC1
HDAC2
HGS
HIPK2
HNF4A
HOXA13
HOXA9
HOXD13
HSD17B3
HUWE1
HYAL2
INSR
IRAK2
ITCH
JUN
KAT2B
KHDRBS1
KPNB1
LAMA5
LATS2
LCK
LEF1
LEMD3
LHX9
LITAF
LMO2
MAP2K1
MAPK1
MAPK3
MAPK8
MAPK9
MECOM
MED15
MED6
MEF2A
MEF2C
MYC
MYOCD
NAGK
NCOA6
NEDD4L
NEDD9
NEFM
NFIA
NFYC
NOTCH4
NUAK2
NUP153
NUP214
OS9
OTUB1
PAK1
PAPOLA
PAPPA
PARD3
PAXIP1
PEX19
PIAS3
PIAS4
PIK3CA
PLIN3
POU2AF1
PPM1A
PPP2R1A
PRKAR1A
PSAP
PSG9
PSMD11
PSMD8
PTMS
RAB34
RAB38
RAN
RANBP6
RANBP9
RARB
RASA1
RASD2
RASL12
RBL1
RHEBL1
RHOA
RHOD
RHOJ
RIT1
RNF123
RNPC3
ROCK1
RPS14
RPS27A
RUNX2
RXRA
SKI
SKIL
SKOR2
SMAD1
SMAD3
SMAD4
SMAD7
SMAD9
SMURF1
SMURF2
SNAPIN
SNIP1
SNRNP70
SNW1
SOD1
SP1
SQSTM1
SRI
ST13
STAG1
STAMBP
STAMBPL1
STRAP
STUB1
SYT1
TBC1D1
TGFBR1
TGFBRAP1
TGIF1
TGM2
TNNT1
TOB1
TP53
TP73
TRIM62
TRMO
TSC2
TUBA1B
UBA52
UBR5
UCHL5
USP9X
WASHC4
XPA
YY1
ZEB1
ZEB2
ZFYVE9
ZMYND11
ZNF41
ZNF510
ZNF8
ZNHIT6
31 interacting genes:
ASCL1
CCNB1
CDK1
COPS5
CSNK2A1
EP300
EPAS1
GATA4
HDAC4
HDAC5
HDAC7
HDAC9
KPNA4
MAPK14
MAPK7
MEF2D
MYOD1
MYOG
NCOA2
NOTCH1
PLA2G12A
SMAD2
SOX18
SP1
SPTBN1
TEAD1
TWIST2
UBE2I
VGLL2
VGLL4
YWHAZ
Entrez ID
4087
4208
HPRD ID
03221
02809
Ensembl ID
ENSG00000175387
ENSG00000081189
Uniprot IDs
B7Z5N5
Q15796
Q53XR6
A0A0D9SFD0
A0A0D9SGI5
A0A0R4J2G5
A0A9L9PYA3
D8L7E9
Q06413
PDB IDs
1DEV
1KHX
1U7V
2LB3
5XOD
5ZOJ
6H3R
6M64
6YIA
6ZVQ
7CO1
Enriched GO Terms of Interacting Partners
?
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleoplasm
SMAD Binding
Regulation Of Signal Transduction
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Transcription Regulator Complex
Regulation Of Primary Metabolic Process
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Communication
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Signaling
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Developmental Process
Positive Regulation Of Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Intracellular Signal Transduction
Chromatin
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Enzyme-linked Receptor Protein Signaling Pathway
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Myotube Differentiation
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Factor Binding
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Striated Muscle Cell Differentiation
Negative Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Nucleoplasm
DNA-binding Transcription Activator Activity
Transcription Regulator Complex
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cell Fate Commitment
Histone Deacetylase Activity, Hydrolytic Mechanism
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Nucleus
Regulation Of Developmental Process
Striated Muscle Tissue Development
Protein Lysine Deacetylase Activity
Negative Regulation Of Metabolic Process
Chromatin
Regulation Of Cardiac Muscle Cell Proliferation
Muscle Tissue Development
Regulation Of Muscle Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Cell Differentiation
Histone Deacetylase Activity
Heart Development
DNA-binding Transcription Factor Activity
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Tagcloud (Difference)
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Tagcloud (Intersection)
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