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SMAD2 and RASD2
Number of citations of the paper that reports this interaction (PMID
15761153
)
154
Data Source:
HPRD
(in vivo)
SMAD2
RASD2
Gene Name
SMAD family member 2
RASD family, member 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Activin Responsive Factor Complex
SMAD Protein Complex
SMAD2-SMAD3 Protein Complex
Plasma Membrane
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Transcription Factor Binding
Phosphatase Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Ubiquitin Protein Ligase Binding
Activating Transcription Factor Binding
Type I Transforming Growth Factor Beta Receptor Binding
Enhancer Binding
SMAD Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
GTPase Activity
GTP Binding
Ubiquitin Conjugating Enzyme Binding
G-protein Beta-subunit Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Ureteric Bud Development
In Utero Embryonic Development
Endoderm Formation
Mesoderm Formation
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
SMAD Protein Complex Assembly
Zygotic Specification Of Dorsal/ventral Axis
Gastrulation
Negative Regulation Of Cell Proliferation
Response To Glucose
Post-embryonic Development
Anterior/posterior Pattern Specification
Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Signal Transduction Involved In Regulation Of Gene Expression
Insulin Secretion
Lung Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Pancreas Development
Primary MiRNA Processing
Activin Receptor Signaling Pathway
Somatic Stem Cell Maintenance
Organ Growth
Intracellular Signal Transduction
Nodal Signaling Pathway
Cell Fate Commitment
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Paraxial Mesoderm Morphogenesis
Developmental Growth
Embryonic Foregut Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Regulation Of Binding
Palate Development
Pericardium Development
SMAD Protein Signal Transduction
Response To Cholesterol
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Synaptic Transmission, Dopaminergic
Small GTPase Mediated Signal Transduction
Locomotory Behavior
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Sumoylation
Regulation Of CAMP-mediated Signaling
Positive Regulation Of Protein Kinase B Signaling
Pathways
Loss of Function of TGFBR2 in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Generic Transcription Pathway
Signaling by NODAL
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
Signaling by Activin
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
207 interactors:
ABTB1
ACVR1B
AKT1
ANAPC10
ANAPC2
ANK3
ANP32B
ANP32E
ANTXR2
AP1B1
ARFGAP3
ARHGEF6
ARL4D
ATP5I
AXIN1
BAZ1A
BPTF
BRCA1
BTBD2
C22orf46
CAMK2A
CAMK2G
CDC16
CDC27
CDC40
CDK2
CDK4
CDK8
CDK9
CISH
COPS5
CREBBP
CSH1
CSH2
CSNK1D
CTNNB1
CUL5
CYP11A1
DAB2
DCAF6
DCUN1D1
DNAJC7
DOCK8
DVL1
DYNC1H1
E2F4
EEF1A1
EID2
EIF3L
ELAC2
EP300
ERBB2IP
ESR1
ESR2
FAM161B
FBN2
FHL2
FHL3
FOXG1
FOXH1
FOXO3
GATAD2B
GFER
GLI3
GRIPAP1
GSC
GTF2I
HDAC1
HDAC2
HGS
HIPK2
HNF4A
HOXA13
HOXA9
HOXD13
HUWE1
INSR
IRAK2
ITCH
JUN
KAT2B
KHDRBS1
KIAA1033
KPNB1
LAMA5
LCK
LEF1
LEMD3
LHX9
LITAF
LMO2
MAPK1
MAPK3
MAPK8
MAPK9
MECOM
MED15
MED6
MEF2A
MEF2C
MLLT4
MYC
MYOCD
NAGK
NCOA6
NEDD4L
NEDD9
NEFM
NF1
NFYC
NOTCH4
NUAK2
NUP153
NUP214
OS9
OTUB1
PAK1
PAPOLA
PAPPA
PARD3
PARD3B
PAXIP1
PEX19
PIAS3
PIAS4
PIK3CA
PLIN3
POU2AF1
PPM1A
PPP2R1A
PRKAR1A
PSAP
PSG9
PSMD11
PSMD8
PTMS
RAB34
RAB38
RAN
RANBP6
RANBP9
RARB
RASD2
RASL12
RBL1
RHEBL1
RHOA
RHOD
RHOJ
RIT1
RNF123
RNPC3
ROCK1
RPS14
RPS27A
RUNX2
RXRA
SKI
SKIL
SKOR2
SMAD1
SMAD3
SMAD4
SMAD7
SMAD9
SMURF1
SMURF2
SNAPIN
SNIP1
SNRNP70
SNW1
SOD1
SP1
SQSTM1
SRI
ST13
ST5
STAG1
STAMBP
STAMBPL1
STRAP
STUB1
SYT1
TBC1D1
TGFBR1
TGFBRAP1
TGIF1
TGM2
TNNT1
TOB1
TP53
TP73
TRIM62
TSC2
TUBA1B
UBA52
UBR5
UCHL5
USP9X
YY1
ZEB1
ZEB2
ZFYVE9
ZMYND11
ZNF41
ZNF8
ZNHIT6
15 interactors:
ACVR1
BMPR1B
GNB1
GNB2
GNB3
PIK3CA
RABAC1
RAF1
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SMURF2
TGFBR1
Entrez ID
4087
23551
HPRD ID
03221
15210
Ensembl ID
ENSG00000175387
ENSG00000100302
Uniprot IDs
B7Z5N5
Q15796
Q53XR6
Q96D21
PDB IDs
1DEV
1KHX
1U7V
2LB3
Enriched GO Terms of Interacting Partners
?
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Organic Substance
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Gene Expression
Response To Organic Substance
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Regulation Of Signal Transduction
Positive Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
RNA Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Signal Transduction
Regulation Of Nitrogen Compound Metabolic Process
Transcription, DNA-templated
Cell Communication
Regulation Of Gene Expression
Negative Regulation Of Cellular Metabolic Process
Signaling
Cellular Response To Stimulus
Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
DNA-templated Transcription, Initiation
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Cellular Response To Growth Factor Stimulus
Transcription From RNA Polymerase II Promoter
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
RNA Metabolic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Signal Transduction
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Cellular Response To Growth Factor Stimulus
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Organic Substance
Response To Growth Factor
Cell Surface Receptor Signaling Pathway
BMP Signaling Pathway
Response To Organic Substance
SMAD Protein Complex Assembly
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Signal Transduction
Activin Receptor Signaling Pathway
Signaling
Primary MiRNA Processing
Cell Communication
Pattern Specification Process
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Heart Development
Intracellular Signal Transduction
Cardiovascular System Development
Mesoderm Development
Regulation Of Epithelial To Mesenchymal Transition
Cellular Response To Stimulus
Urogenital System Development
Negative Regulation Of Cell Proliferation
Gastrulation
Regulation Of Ossification
Mesenchyme Development
Tissue Development
Mesoderm Formation
Embryonic Pattern Specification
Mesoderm Morphogenesis
Regulation Of Cartilage Development
Positive Regulation Of Signal Transduction
Positive Regulation Of Ossification
Stem Cell Development
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Regulation Of Signal Transduction
Signal Transduction By Phosphorylation
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Response To Stimulus
Cell Fate Commitment
Tagcloud
?
adenoviral
cbp
coactivators
e1a
enhancement
fashion
interacted
interacting
intrinsic
lux
mapped
mediating
minimal
oncoprotein
p300
p3tp
possess
possibility
raise
regulators
rest
signalling
smad3
smads
superfamily
tgf
transactivation
transforming
Tagcloud (Difference)
?
adenoviral
cbp
coactivators
e1a
enhancement
fashion
interacted
interacting
intrinsic
lux
mapped
mediating
minimal
oncoprotein
p300
p3tp
possess
possibility
raise
regulators
rest
signalling
smad3
smads
superfamily
tgf
transactivation
transforming
Tagcloud (Intersection)
?