SMAD2 and SLC6A4

		SMAD2	SLC6A4
Description		SMAD family member 2	solute carrier family 6 member 4
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Activin Responsive Factor Complex Protein-containing Complex SMAD Protein Complex Homomeric SMAD Protein Complex Heteromeric SMAD Protein Complex	Endosome Plasma Membrane Focal Adhesion Endosome Membrane Endomembrane System Membrane Presynaptic Membrane Cell Projection Neuron Projection Membrane Raft Synapse Postsynaptic Membrane Anchoring Junction Serotonergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding SMAD Binding Metal Ion Binding Tau Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Disordered Domain Specific Binding DNA-binding Transcription Factor Binding	Integrin Binding Monoatomic Cation Channel Activity Neurotransmitter Transmembrane Transporter Activity Serotonin:sodium:chloride Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Antiporter Activity Syntaxin-1 Binding Cocaine Binding Sodium Ion Binding Identical Protein Binding Metal Ion Binding Nitric-oxide Synthase Binding Actin Filament Binding Serotonin Binding
	Biological Process	Ureteric Bud Development In Utero Embryonic Development Endoderm Formation Mesoderm Formation Regionalization Determination Of Left/right Asymmetry In Lateral Mesoderm Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis DNA-templated Transcription Regulation Of DNA-templated Transcription Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Gastrulation Pattern Specification Process Endoderm Development Mesoderm Development Heart Development Cell Population Proliferation Anatomical Structure Morphogenesis Response To Glucose Post-embryonic Development Embryonic Pattern Specification Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Secretion Cell Differentiation Negative Regulation Of Ossification Lung Development Positive Regulation Of BMP Signaling Pathway Pancreas Development Primary MiRNA Processing Activin Receptor Signaling Pathway Organ Growth Intracellular Signal Transduction Nodal Signaling Pathway Cell Fate Commitment Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Morphogenesis Developmental Growth Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Multicellular Organismal Process Pericardium Development SMAD Protein Signal Transduction Mesenchyme Development Trophoblast Cell Migration Secondary Palate Development Response To Cholesterol Response To Transforming Growth Factor Beta Odontoblast Differentiation	Response To Hypoxia Neurotransmitter Transport Serotonin Transport Amino Acid Transport Response To Nutrient Memory Circadian Rhythm Response To Xenobiotic Stimulus Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Serotonin Secretion Monoamine Transport Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Sodium Ion Transmembrane Transport Vasoconstriction Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Organ Growth Behavioral Response To Cocaine Enteric Nervous System Development Brain Morphogenesis Serotonin Uptake Membrane Depolarization Male Mating Behavior Platelet Aggregation Cellular Response To Retinoic Acid Cellular Response To CGMP Regulation Of Thalamus Size Neurotransmitter Reuptake Conditioned Place Preference
Pathways		Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Germ layer formation at gastrulation Formation of axial mesoderm Formation of definitive endoderm Formation of definitive endoderm	Serotonin clearance from the synaptic cleft SLC-mediated transport of neurotransmitters
Drugs		Dexfosfoserine	Fluvoxamine Amphetamine Phentermine Tramadol Citalopram Benzatropine Venlafaxine Atomoxetine Amitriptyline Protriptyline Loxapine Meperidine Imipramine Fluoxetine Duloxetine Dextromethorphan Nortriptyline Amoxapine Fenfluramine Mazindol Trazodone Verapamil Paroxetine Trimipramine Minaprine Pseudoephedrine Cocaine Cyclobenzaprine Dopamine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Escitalopram Dexfenfluramine Aripiprazole Clomipramine Ephedra sinica root MMDA Midomafetamine 4-Methoxyamphetamine Metamfetamine Nomifensine Zimelidine Amineptine Bicifadine Milnacipran OPC-14523 CRx-119 Amitifadine Lumateperone Mianserin Tesofensine Tapentadol Vilazodone Desvenlafaxine Dexmethylphenidate Serotonin Levomilnacipran Butriptyline Vortioxetine Dosulepin Nisoxetine Lorpiprazole Zotepine Dasotraline
Diseases		Colorectal cancer
GWAS		Coronary artery disease in type 1 diabetes ( 29695241) Daytime nap ( 33568662) Lung cancer in ever smokers ( 28604730) Menarche (age at onset) ( 27182965)	Brain morphology (MOSTest) ( 32665545) Height ( 28552196)
Interacting Genes		220 interacting genes: ABTB1 ACVR1B AFDN AKT1 ANAPC10 ANAPC2 ANK3 ANP32B ANP32E ANTXR2 AP1B1 ARFGAP3 ARHGEF6 ARL4D ATP5ME AXIN1 BAZ1A BECN1 BPTF BRCA1 BTBD2 C22orf46P CAMK2A CAMK2G CDC16 CDC27 CDC40 CDK2 CDK4 CDK8 CDK9 CISH COPS5 CORO2A CREBBP CSH1 CSH2 CSNK1D CTNNB1 CUL5 CYLC2 CYP11A1 DAB2 DCAF6 DCUN1D1 DENND2B DNAJB5 DNAJC7 DOCK8 DVL1 DYNC1H1 DYRK1A E2F4 EEF1A1 EID2 EIF3L ELAC2 EP300 ERBIN ESR1 ESR2 FAM161B FBN2 FBP2 FHL2 FHL3 FOXG1 FOXH1 FOXO3 GATAD2B GFER GLI3 GRIPAP1 GSC GTF2I HDAC1 HDAC2 HGS HIPK2 HNF4A HOXA13 HOXA9 HOXD13 HSD17B3 HUWE1 HYAL2 INSR IRAK2 ITCH JUN KAT2B KHDRBS1 KPNB1 LAMA5 LATS2 LCK LEF1 LEMD3 LHX9 LITAF LMO2 MAP2K1 MAPK1 MAPK3 MAPK8 MAPK9 MECOM MED15 MED6 MEF2A MEF2C MYC MYOCD NAGK NCOA6 NEDD4L NEDD9 NEFM NFIA NFYC NOTCH4 NUAK2 NUP153 NUP214 OS9 OTUB1 PAK1 PAPOLA PAPPA PARD3 PAXIP1 PEX19 PIAS3 PIAS4 PIK3CA PLIN3 POU2AF1 PPM1A PPP2R1A PRKAR1A PSAP PSG9 PSMD11 PSMD8 PTMS RAB34 RAB38 RAN RANBP6 RANBP9 RARB RASA1 RASD2 RASL12 RBL1 RHEBL1 RHOA RHOD RHOJ RIT1 RNF123 RNPC3 ROCK1 RPS14 RPS27A RUNX2 RXRA SKI SKIL SKOR2 SMAD1 SMAD3 SMAD4 SMAD7 SMAD9 SMURF1 SMURF2 SNAPIN SNIP1 SNRNP70 SNW1 SOD1 SP1 SQSTM1 SRI ST13 STAG1 STAMBP STAMBPL1 STRAP STUB1 SYT1 TBC1D1 TGFBR1 TGFBRAP1 TGIF1 TGM2 TNNT1 TOB1 TP53 TP73 TRIM62 TRMO TSC2 TUBA1B UBA52 UBR5 UCHL5 USP9X WASHC4 XPA YY1 ZEB1 ZEB2 ZFYVE9 ZMYND11 ZNF41 ZNF510 ZNF8 ZNHIT6	7 interacting genes: A2M CALR CANX GPM6B STX1A VAMP2 YBX1
Entrez ID		4087	6532
HPRD ID		03221	01640
Ensembl ID		ENSG00000175387	ENSG00000108576
Uniprot IDs		B7Z5N5 Q15796 Q53XR6	B2R7Y7 P31645
PDB IDs		1DEV 1KHX 1U7V 2LB3 5XOD 5ZOJ 6H3R 6M64 6YIA 6ZVQ 7CO1	5I6X 5I6Z 5I71 5I73 5I74 5I75 6AWN 6AWO 6AWP 6AWQ 6DZV 6DZW 6DZY 6DZZ 6VRH 6VRK 6VRL 6W2B 6W2C 7LI6 7LI7 7LI8 7LI9 7LIA 7LWD 7MGW 7TXT
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Nucleoplasm SMAD Binding Regulation Of Signal Transduction Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signaling Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Transcription Regulator Complex Regulation Of Primary Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Communication Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Signaling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Developmental Process Positive Regulation Of Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Intracellular Signal Transduction Chromatin Negative Regulation Of Signaling Negative Regulation Of Cell Communication Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process	Intracellular Protein Localization Synaptic Vesicle Endocytosis Presynaptic Endocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Protein Transport Establishment Of Protein Localization Calcium-dependent Protein Binding Vesicle-mediated Transport In Synapse Protein Folding In Endoplasmic Reticulum SNARE Complex Assembly Protein Localization To Extracellular Region Protein Secretion Secretion By Cell Establishment Of Protein Localization To Extracellular Region Signal Release Endoplasmic Reticulum Quality Control Compartment Secretion Lumenal Side Of Endoplasmic Reticulum Membrane Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis SNAP Receptor Activity SNARE Complex Insulin Secretion SNARE Binding Peptide Hormone Secretion Myosin Head/neck Binding Peptide Secretion Voltage-gated Potassium Channel Complex Negative Regulation Of Complement Activation, Lectin Pathway ERAD Pathway Endocytosis Hormone Secretion Hormone Transport Homomeric SMAD Protein Complex Peptide Transport Organelle Membrane Fusion Regulated Exocytosis Vesicle Fusion Secretory Granule Interleukin-8 Binding Unfolded Protein Binding Response To Biphenyl Regulation Of Ossification Negative Regulation Of Serotonin Uptake Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis MiRNA Transport
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