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LNX2 and LNX1
Number of citations of the paper that reports this interaction (PMID
11922143
)
8
Data Source:
BioGRID
(two hybrid)
HPRD
(in vitro)
LNX2
LNX1
Gene Name
ligand of numb-protein X 2
ligand of numb-protein X 1, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations
Cellular Component
Cytoplasm
Molecular Function
Protein Binding
Zinc Ion Binding
PDZ Domain Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
PDZ Domain Binding
Biological Process
Protein Homooligomerization
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS
Large B-cell lymphoma (
21471979
)
DNA methylation (variation) (
23725790
)
Protein-Protein Interactions
17 interactors:
CBX4
CXADR
HOXA1
IGSF5
LNX1
MDGA1
NUMB
PDZRN3
PDZRN4
PKDREJ
RLIM
RNF138
SHISA2
UBE2I
UBE2T
UBE2Z
USP2
218 interactors:
ABCA1
ABCB1
ABR
ACAT2
ACY3
ADRA1D
AGTRAP
AIDA
AIMP2
AKIRIN2
ALDOC
ALKBH3
AMMECR1L
APIP
APOL4
APP
ARHGAP6
ARHGEF16
ARVCF
ATPAF2
ATRIP
AURKC
BCR
BLVRA
BPIFA1
C1QTNF1
CA8
CALCOCO2
CAMK2N2
CATSPERD
CCDC101
CCDC102B
CCDC114
CCDC85B
CDA
CDC42EP4
CEP72
CGN
CIB3
CIRBP
CITED1
CLDN1
CLDN17
CLDN2
CLK2
COIL
CPNE2
CTBP1
CTNND2
CTSO
CUTC
CXADR
DAB1
DAPK1
DCTD
DCUN1D5
DDX17
DEPTOR
DNPEP
DOCK9
DPF2
DVL3
EBF4
EHMT2
EIF4H
ENOX1
EPHB3
EXOC8
FAM118A
FAM124A
FAM212B
FAM9B
FBP1
FBXL12
FHL3
GAS2L2
GDI1
GIPR
GJD4
GOLPH3L
GPR142
GRB2
GRIN1
HMBOX1
HOMEZ
HSBP1
HTR2B
HUNK
IGSF5
IL3RA
ILF3
INSC
ISCU
JOSD1
KALRN
KCNA4
KCTD1
KCTD13
KCTD17
KCTD6
KHDRBS3
KIAA1598
KLHL12
KRT15
KRTAP4-12
KRTAP4-2
KRTAP9-2
KXD1
LCLAT1
LDOC1
LGALS14
LGR6
LNX2
LRRC3B
LSM2
MAGEA11
MAGEB18
MAPK9
MEMO1
METTL21A
MRFAP1L1
MRPS24
MTMR9
MTUS2
MUSTN1
MVB12B
NADK
NAGK
NCK2
NECAB2
NEK6
NKD2
NME7
NOTCH2NL
NRCAM
NUDT14
NUMB
NUP37
NXT2
ORMDL3
OSBP2
OSGIN1
PAFAH1B3
PAICS
PBK
PBLD
PCBD1
PDZRN3
PDZRN4
PKDREJ
PKM
PKP4
POMGNT1
PPIA
PPID
PQBP1
PRR13
PTGIR
PTS
RABAC1
RAD51D
RAD54B
RBMX
RBMY1A1
RFPL3
ROBO3
ROPN1
RPIA
RUFY4
RUVBL2
SAPCD1
SAT1
SCLT1
SDK1
SLC6A15
SLC6A5
SNCB
SNRNP25
SNRPF
SPHKAP
SRSF1
SSNA1
SSTR3
STAC2
STRN
STX5
SUV39H1
SUV39H2
TBCEL
THAP7
TIFA
TMEM14C
TNFRSF18
TPM4
TRAF2
TRIM23
TRIM39
TRIM54
TRIP13
TRMT12
TSC2
TSC22D4
TSSK3
TYRO3
UBE2D2
ULK2
VCP
VRK2
WAC
WNT8A
WWP1
ZADH2
ZBTB43
ZBTB8A
ZCCHC10
ZFP64
ZNF581
ZNF593
Entrez ID
222484
84708
HPRD ID
10042
17287
Ensembl ID
ENSG00000139517
ENSG00000072201
Uniprot IDs
Q8N448
Q8TBB1
PDB IDs
2VWR
3B76
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Cellular Protein Modification Process
Protein Sumoylation
Cellular Protein Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Optokinetic Behavior
Abducens Nerve Formation
Random Inactivation Of X Chromosome
Positive Regulation Of SUMO Transferase Activity
Protein Catabolic Process
Facial Nucleus Development
Positive Regulation Of Polarized Epithelial Cell Differentiation
Protein Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Rhombomere 4 Development
Semicircular Canal Formation
Cellular Macromolecule Catabolic Process
Rhombomere 3 Development
Rhombomere 5 Development
Neuroblast Division In Subventricular Zone
Protein K27-linked Ubiquitination
Protein K29-linked Ubiquitination
AV Node Cell To Bundle Of His Cell Communication
Cellular Component Assembly
Protein Homooligomerization
Protein Oligomerization
Protein Complex Assembly
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cellular Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Cellular Process
Regulation Of Cellular Component Organization
Cellular Aromatic Compound Metabolic Process
Regulation Of Rho Protein Signal Transduction
Response To Stimulus
Developmental Process
Cellular Metabolic Process
Peptidyl-lysine Dimethylation
Heterocycle Metabolic Process
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Neutrophil Degranulation
Cellular Response To Stimulus
Viral Process
Programmed Cell Death
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Splicing
Cellular Nitrogen Compound Metabolic Process
Protein Tetramerization
Cell Death
Apoptotic Process
Death
Neuron Recognition
Cell Communication
Signaling
Regulation Of Neutrophil Degranulation
Negative Regulation Of Neutrophil Activation
Viral Release From Host Cell
Regulation Of Rho GTPase Activity
Cell-cell Junction Organization
Protein Autophosphorylation
Response To Abiotic Stimulus
Organelle Organization
Regulation Of Cell Morphogenesis
Nitrogen Compound Metabolic Process
Axon Midline Choice Point Recognition
Positive Regulation Of Rho GTPase Activity
Cell Morphogenesis Involved In Differentiation
Regulation Of Protein Homodimerization Activity
Regulation Of Ras Protein Signal Transduction
Protein Heterooligomerization
Biosynthetic Process
Tagcloud
?
amplicons
aneuploidy
behind
candidates
colorectal
copy
crc
dis3
downregulated
drivers
gains
gpr180
imbalances
klf5
landscape
mapping
notch
nupl1
offering
oncogene
polr1d
pomp
profiling
rnai
silencing
slc7a1
tcf7l2
unfinished
wnt
Tagcloud (Difference)
?
amplicons
aneuploidy
behind
candidates
colorectal
copy
crc
dis3
downregulated
drivers
gains
gpr180
imbalances
klf5
landscape
mapping
notch
nupl1
offering
oncogene
polr1d
pomp
profiling
rnai
silencing
slc7a1
tcf7l2
unfinished
wnt
Tagcloud (Intersection)
?