LNX1 and CAMK2N2

Number of citations of the paper that reports this interaction (PMID 22087225)
2

Data Source:
BioGRID (pull down, affinity chromatography technology)

		LNX1	CAMK2N2
Gene Name		ligand of numb-protein X 1, E3 ubiquitin protein ligase	calcium/calmodulin-dependent protein kinase II inhibitor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Centrosome Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity PDZ Domain Binding	Calcium-dependent Protein Kinase Inhibitor Activity Protein Kinase Binding
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Homooligomerization	Negative Regulation Of Protein Kinase Activity
Pathways
Drugs
Diseases
GWAS		DNA methylation (variation) ( 23725790)	Major depressive disorder ( 22472876)
Protein-Protein Interactions		218 interactors: ABCA1 ABCB1 ABR ACAT2 ACY3 ADRA1D AGTRAP AIDA AIMP2 AKIRIN2 ALDOC ALKBH3 AMMECR1L APIP APOL4 APP ARHGAP6 ARHGEF16 ARVCF ATPAF2 ATRIP AURKC BCR BLVRA BPIFA1 C1QTNF1 CA8 CALCOCO2 CAMK2N2 CATSPERD CCDC101 CCDC102B CCDC114 CCDC85B CDA CDC42EP4 CEP72 CGN CIB3 CIRBP CITED1 CLDN1 CLDN17 CLDN2 CLK2 COIL CPNE2 CTBP1 CTNND2 CTSO CUTC CXADR DAB1 DAPK1 DCTD DCUN1D5 DDX17 DEPTOR DNPEP DOCK9 DPF2 DVL3 EBF4 EHMT2 EIF4H ENOX1 EPHB3 EXOC8 FAM118A FAM124A FAM212B FAM9B FBP1 FBXL12 FHL3 GAS2L2 GDI1 GIPR GJD4 GOLPH3L GPR142 GRB2 GRIN1 HMBOX1 HOMEZ HSBP1 HTR2B HUNK IGSF5 IL3RA ILF3 INSC ISCU JOSD1 KALRN KCNA4 KCTD1 KCTD13 KCTD17 KCTD6 KHDRBS3 KIAA1598 KLHL12 KRT15 KRTAP4-12 KRTAP4-2 KRTAP9-2 KXD1 LCLAT1 LDOC1 LGALS14 LGR6 LNX2 LRRC3B LSM2 MAGEA11 MAGEB18 MAPK9 MEMO1 METTL21A MRFAP1L1 MRPS24 MTMR9 MTUS2 MUSTN1 MVB12B NADK NAGK NCK2 NECAB2 NEK6 NKD2 NME7 NOTCH2NL NRCAM NUDT14 NUMB NUP37 NXT2 ORMDL3 OSBP2 OSGIN1 PAFAH1B3 PAICS PBK PBLD PCBD1 PDZRN3 PDZRN4 PKDREJ PKM PKP4 POMGNT1 PPIA PPID PQBP1 PRR13 PTGIR PTS RABAC1 RAD51D RAD54B RBMX RBMY1A1 RFPL3 ROBO3 ROPN1 RPIA RUFY4 RUVBL2 SAPCD1 SAT1 SCLT1 SDK1 SLC6A15 SLC6A5 SNCB SNRNP25 SNRPF SPHKAP SRSF1 SSNA1 SSTR3 STAC2 STRN STX5 SUV39H1 SUV39H2 TBCEL THAP7 TIFA TMEM14C TNFRSF18 TPM4 TRAF2 TRIM23 TRIM39 TRIM54 TRIP13 TRMT12 TSC2 TSC22D4 TSSK3 TYRO3 UBE2D2 ULK2 VCP VRK2 WAC WNT8A WWP1 ZADH2 ZBTB43 ZBTB8A ZCCHC10 ZFP64 ZNF581 ZNF593	4 interactors: ARHGAP32 CAMK2A CAMK2B LNX1
Entrez ID		84708	94032
HPRD ID		17287	16377
Ensembl ID		ENSG00000072201	ENSG00000163888
Uniprot IDs		Q8TBB1	Q96S95
PDB IDs		3B76
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Protein Homooligomerization Protein Oligomerization Protein Complex Assembly Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Regulation Of Cellular Component Organization Cellular Aromatic Compound Metabolic Process Regulation Of Rho Protein Signal Transduction Response To Stimulus Developmental Process Cellular Metabolic Process Peptidyl-lysine Dimethylation Heterocycle Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Neutrophil Degranulation Cellular Response To Stimulus Viral Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process Protein Tetramerization Cell Death Apoptotic Process Death Neuron Recognition Cell Communication Signaling Regulation Of Neutrophil Degranulation Negative Regulation Of Neutrophil Activation Viral Release From Host Cell Regulation Of Rho GTPase Activity Cell-cell Junction Organization Protein Autophosphorylation Response To Abiotic Stimulus Organelle Organization Regulation Of Cell Morphogenesis Nitrogen Compound Metabolic Process Axon Midline Choice Point Recognition Positive Regulation Of Rho GTPase Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Homodimerization Activity Regulation Of Ras Protein Signal Transduction Protein Heterooligomerization Biosynthetic Process	Regulation Of Cellular Response To Heat Regulation Of Neuronal Synaptic Plasticity Cellular Response To Heat Response To Heat Peptidyl-serine Phosphorylation Interferon-gamma-mediated Signaling Pathway Inhibitory G-protein Coupled Receptor Phosphorylation Cellular Response To Interferon-gamma G1/S Transition Of Mitotic Cell Cycle Regulation Of Synaptic Plasticity Response To Interferon-gamma Activation Of Meiosis Involved In Egg Activation Response To Temperature Stimulus Regulation Of Calcium Ion Transport Protein Autophosphorylation Activation Of Meiosis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Synaptic Transmission Calcium Ion Transport Regulation Of Synaptic Transmission, Cholinergic Regulation Of Skeletal Muscle Adaptation Regulation Of Synapse Structural Plasticity Cytokine-mediated Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Meiotic Nuclear Division Egg Activation Regulation Of Synapse Maturation Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Cytokine Stimulus Synaptic Transmission Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Ion Transport Positive Regulation Of Dendritic Spine Development Mitotic Cell Cycle Process Response To Cytokine Regulation Of Long-term Neuronal Synaptic Plasticity Response To Ischemia Regulation Of Mitochondrial Membrane Permeability Regulation Of Dendritic Spine Morphogenesis Mitotic Cell Cycle Regulation Of Membrane Permeability Positive Regulation Of Dendrite Morphogenesis Innate Immune Response Metal Ion Transport
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