LNX1 and PAICS

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LNX1	PAICS
Gene Name		ligand of numb-protein X 1, E3 ubiquitin protein ligase	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
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Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity PDZ Domain Binding	Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Homooligomerization	Purine Nucleobase Metabolic Process 'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways			Purine ribonucleoside monophosphate biosynthesis Purine metabolism Metabolism of nucleotides
Drugs
Diseases
GWAS		DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		218 interactors: ABCA1 ABCB1 ABR ACAT2 ACY3 ADRA1D AGTRAP AIDA AIMP2 AKIRIN2 ALDOC ALKBH3 AMMECR1L APIP APOL4 APP ARHGAP6 ARHGEF16 ARVCF ATPAF2 ATRIP AURKC BCR BLVRA BPIFA1 C1QTNF1 CA8 CALCOCO2 CAMK2N2 CATSPERD CCDC101 CCDC102B CCDC114 CCDC85B CDA CDC42EP4 CEP72 CGN CIB3 CIRBP CITED1 CLDN1 CLDN17 CLDN2 CLK2 COIL CPNE2 CTBP1 CTNND2 CTSO CUTC CXADR DAB1 DAPK1 DCTD DCUN1D5 DDX17 DEPTOR DNPEP DOCK9 DPF2 DVL3 EBF4 EHMT2 EIF4H ENOX1 EPHB3 EXOC8 FAM118A FAM124A FAM212B FAM9B FBP1 FBXL12 FHL3 GAS2L2 GDI1 GIPR GJD4 GOLPH3L GPR142 GRB2 GRIN1 HMBOX1 HOMEZ HSBP1 HTR2B HUNK IGSF5 IL3RA ILF3 INSC ISCU JOSD1 KALRN KCNA4 KCTD1 KCTD13 KCTD17 KCTD6 KHDRBS3 KIAA1598 KLHL12 KRT15 KRTAP4-12 KRTAP4-2 KRTAP9-2 KXD1 LCLAT1 LDOC1 LGALS14 LGR6 LNX2 LRRC3B LSM2 MAGEA11 MAGEB18 MAPK9 MEMO1 METTL21A MRFAP1L1 MRPS24 MTMR9 MTUS2 MUSTN1 MVB12B NADK NAGK NCK2 NECAB2 NEK6 NKD2 NME7 NOTCH2NL NRCAM NUDT14 NUMB NUP37 NXT2 ORMDL3 OSBP2 OSGIN1 PAFAH1B3 PAICS PBK PBLD PCBD1 PDZRN3 PDZRN4 PKDREJ PKM PKP4 POMGNT1 PPIA PPID PQBP1 PRR13 PTGIR PTS RABAC1 RAD51D RAD54B RBMX RBMY1A1 RFPL3 ROBO3 ROPN1 RPIA RUFY4 RUVBL2 SAPCD1 SAT1 SCLT1 SDK1 SLC6A15 SLC6A5 SNCB SNRNP25 SNRPF SPHKAP SRSF1 SSNA1 SSTR3 STAC2 STRN STX5 SUV39H1 SUV39H2 TBCEL THAP7 TIFA TMEM14C TNFRSF18 TPM4 TRAF2 TRIM23 TRIM39 TRIM54 TRIP13 TRMT12 TSC2 TSC22D4 TSSK3 TYRO3 UBE2D2 ULK2 VCP VRK2 WAC WNT8A WWP1 ZADH2 ZBTB43 ZBTB8A ZCCHC10 ZFP64 ZNF581 ZNF593	11 interactors: CEP76 CHD3 FXR2 L3MBTL2 LNX1 MOB4 NIF3L1 NUDT18 PRKAG1 SMARCD1 TERF1
Entrez ID		84708	10606
HPRD ID		17287	01401
Ensembl ID		ENSG00000072201	ENSG00000128050
Uniprot IDs		Q8TBB1	P22234
PDB IDs		3B76	2H31
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Protein Homooligomerization Protein Oligomerization Protein Complex Assembly Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Regulation Of Cellular Component Organization Cellular Aromatic Compound Metabolic Process Regulation Of Rho Protein Signal Transduction Response To Stimulus Developmental Process Cellular Metabolic Process Peptidyl-lysine Dimethylation Heterocycle Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Neutrophil Degranulation Cellular Response To Stimulus Viral Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process Protein Tetramerization Cell Death Apoptotic Process Death Neuron Recognition Cell Communication Signaling Regulation Of Neutrophil Degranulation Negative Regulation Of Neutrophil Activation Viral Release From Host Cell Regulation Of Rho GTPase Activity Cell-cell Junction Organization Protein Autophosphorylation Response To Abiotic Stimulus Organelle Organization Regulation Of Cell Morphogenesis Nitrogen Compound Metabolic Process Axon Midline Choice Point Recognition Positive Regulation Of Rho GTPase Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Homodimerization Activity Regulation Of Ras Protein Signal Transduction Protein Heterooligomerization Biosynthetic Process	Chromatin Modification Chromatin Organization GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process Chromosome Organization Protein Oligomerization Cell Cycle Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization G2/M Transition Of Mitotic Cell Cycle Telomeric Loop Formation Age-dependent Telomere Shortening Dihydrobiopterin Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Microtubule Cytoskeleton Organization Chromatin Assembly Or Disassembly Cell Cycle Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Microtubule-based Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Chromatin-mediated Maintenance Of Transcription Deoxyribonucleoside Diphosphate Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Centriole Replication Purine Ribonucleoside Catabolic Process Protein Homooligomerization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Microtubule Polymerization Nucleosome Disassembly Regulation Of Telomerase Activity Regulation Of Cell Cycle Deoxyribose Phosphate Catabolic Process Positive Regulation Of Gene Expression, Epigenetic Regulation Of Telomere Maintenance Protein Complex Assembly RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Purine Ribonucleotide Catabolic Process Regulation Of Glycolytic Process
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