LNX1 and ABCB1

Number of citations: 0 (PubMedID 22889411)
Data Source: BioGRID (two hybrid)

		LNX1	ABCB1
Name		ligand of numb-protein X 1	ATP binding cassette subfamily B member 1
Structure
GO Annotations	Cellular Component	Cytoplasm Hippocampal Mossy Fiber To CA3 Synapse Postsynapse	Cytoplasm Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Apical Part Of Cell Extracellular Exosome External Side Of Apical Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity PDZ Domain Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity Ubiquitin Protein Ligase Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Phosphatidylethanolamine Flippase Activity Ceramide Floppase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Floppase Activity ABC-type Transporter Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Nervous System Development Protein Ubiquitination Synapse Maturation	G2/M Transition Of Mitotic Cell Cycle Response To Hypoxia Placenta Development Xenobiotic Metabolic Process Lipid Transport Female Pregnancy Lactation Circadian Rhythm Response To Xenobiotic Stimulus Hormone Transport Response To Mycotoxin Response To Nutrient Levels Response To Estradiol Response To Lipopolysaccharide Response To Progesterone Response To Vitamin A Response To Vitamin D Response To Glucagon Maintenance Of Blood-brain Barrier Cellular Response To Mycotoxin Daunorubicin Transport Phospholipid Translocation Response To Cadmium Ion Terpenoid Transport Intestinal Absorption Transmembrane Transport Establishment Of Blood-brain Barrier Transepithelial Transport Cellular Response To External Biotic Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Antibiotic Cellular Response To Alkaloid Cellular Response To Tumor Necrosis Factor Cellular Response To Estradiol Stimulus Cellular Hyperosmotic Salinity Response Response To Dexamethasone Cellular Response To Dexamethasone Stimulus Stem Cell Proliferation Response To Thyroxine Response To Alcohol Response To Antineoplastic Agent Ceramide Translocation Export Across Plasma Membrane Transport Across Blood-brain Barrier Response To L-glutamate Protein Localization To Bicellular Tight Junction Response To Glycoside Negative Regulation Of Sensory Perception Of Pain Cellular Response To Nonylphenol Positive Regulation Of Establishment Of Sertoli Cell Barrier Regulation Of Intestinal Absorption Carboxylic Acid Transmembrane Transport Cellular Response To Borneol Cellular Response To L-glutamate Response To Codeine Response To Quercetin Response To Cyclosporin A Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Xenobiotic Transport Across Blood-brain Barrier Establishment Of Blood-retinal Barrier Positive Regulation Of Response To Drug Regulation Of Chloride Transport
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Abacavir transmembrane transport ABC-family proteins mediated transport Atorvastatin ADME Prednisone ADME
Drugs		None	ATP Medroxyprogesterone acetate Verapamil Roxithromycin Fentanyl Voacamine Elacridar Tesmilifene FM-VP4 Zosuquidar Tariquidar Miltefosine Tocofersolan Hycanthone Concanamycin A Dexverapamil Emopamil Lomerizine Tetrandrine Dofequidar Dexniguldipine ONT-093 HM-30181 Desmethylsertraline Reversin 121 Azvudine
GWAS		Beard thickness ( 26926045 ) Cervical artery dissection ( 25420145 ) DNA methylation (variation) ( 23725790 ) Heel bone mineral density ( 30598549 ) Height ( 28552196 ) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912 ) Uterine fibroids ( 30194396 31649266 )	Appendicular lean mass ( 33097823 ) Bone mineral density (spine) and age at menarche ( 26312577 ) Cerebral microbleeds ( 32913026 ) Gallbladder cancer ( 28274756 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Neurological blood protein biomarker levels ( 31320639 ) Persistent chemotherapy-induced alopecia in breast cancer ( 32756886 )
Interacting Genes		476 interacting genes: ABCA1 ABCB1 ABI2 ABR ACAT2 ACTN1 ACTN3 ACTN4 ACY3 ADAMTSL4 ADRA1D AGTRAP AIDA AIMP2 AKIRIN2 ALDOC ALKBH3 AMMECR1L ANKS1A AP1M1 APIP APOL4 APP ARF3 ARFIP2 ARHGAP6 ARHGEF16 ARVCF ATPAF2 ATRIP AURKB AURKC AXIN2 BCR BEND7 BICD2 BIRC2 BLVRA BLZF1 BORCS6 BPIFA1 BTBD1 C10orf88 C1QTNF1 CA8 CABP5 CADPS CALCOCO2 CAMK2N2 CARD9 CASP6 CATSPERD CBX1 CBY1 CBY2 CCBE1 CCDC102B CCDC33 CCDC85B CCDC88B CCDC91 CCNDBP1 CDA CDC42EP4 CDIPT CDKN2D CEP70 CEP72 CEP76 CEP85 CGN CIB3 CIRBP CITED1 CLDN1 CLDN17 CLDN2 CLK1 CLK2 CLK3 CMTM5 COIL CPNE2 CPSF7 CRACR2B CRX CTBP1 CTNND2 CTSO CUTC CXADR CYSLTR2 CYSRT1 DAB1 DAPK1 DCTD DCTPP1 DCUN1D5 DDIT3 DDX17 DENND1B DEPTOR DERL1 DEUP1 DHPS DMC1 DNPEP DOCK9 DPF2 DRAP1 DRG1 DSCAM DTX2 DUSP29 DVL3 DYDC1 DYNLT1 EBF4 EDC3 EEF2KMT EFEMP2 EFHC2 EGLN3 EHMT2 EIF1AD EIF4A3 EIF4H ENOX1 ENOX2 EPHB3 EPM2AIP1 EVI5L EXOC8 EXOSC1 EXOSC4 EXOSC8 FAM118A FAM124A FAM90A1 FAM9B FASN FBP1 FBXL12 FHL3 FOXP2 FSD2 FXR1 GAS2L2 GDI1 GIPR GJD2 GJD4 GLRX3 GMCL1 GMNN GOLPH3L GPKOW GPR142 GRAP2 GRB2 GRIN1 GRIPAP1 GUCD1 HDX HEXIM2 HIP1 HMBOX1 HMG20A HNRNPF HNRNPH1 HOMER3 HOMEZ HOOK2 HOXA1 HSBP1 HSF2BP HTR2B HUNK IGSF5 IHO1 IKZF3 IL16 IL3RA ILF3 INKA2 INO80E INSC IP6K3 ISCU JAK3 JOSD1 KALRN KATNAL2 KCNA4 KCTD1 KCTD13 KCTD17 KCTD6 KCTD7 KCTD9 KHDRBS2 KHDRBS3 KIAA1328 KIF24 KIFC3 KLHL12 KPRP KRT15 KRT16 KRT40 KRTAP1-1 KRTAP10-8 KRTAP12-3 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 KXD1 LCLAT1 LCP2 LDB2 LDOC1 LEPROTL1 LGALS14 LGR6 LHX2 LNX2 LONRF1 LRRC3B LRRC73 LSM2 LUZP4 LZTS1 MAD1L1 MAGEA11 MAGEB18 MAPK9 MAPRE2 MEMO1 MEOX2 METTL21A MID2 MLX MRFAP1L1 MRPS24 MRPS6 MSANTD4 MSC MTMR9 MTUS2 MUSTN1 MVB12B MYEF2 NAB2 NADK NAGK NBPF19 NCK2 NDC80 NDOR1 NDUFAB1 NECAB1 NECAB2 NEK6 NKD2 NME1 NME7 NOTCH2NLA NRCAM NUDT14 NUMB NUP37 NUP62 NXT2 ODAD1 ORMDL1 ORMDL3 OSBP2 OSBPL3 OSGIN1 PAFAH1B3 PAICS PAK5 PBK PBLD PCBD1 PDE3B PDZRN3 PDZRN4 PFDN5 PKDREJ PKM PKP4 PLEKHA2 PNMA1 PNMA3 PNMA5 PNMT POMGNT1 POU6F2 PPIA PPID PPIH PPP1R13B PQBP1 PRDM14 PRKAR1B PRKRA PRMT5 PRPH PRR13 PRTFDC1 PSMC1 PSME2 PSME3 PSMF1 PTGIR PTGR3 PTPN11 PTS PURB QARS1 RAB33A RABAC1 RABIF RAD51D RAD54B RALY RASL11B RBAK RBCK1 RBM20 RBMX RBMY1A1 RBMY1F RBMY1J REEP6 RFPL3 RGS20 RIOX2 ROBO3 ROPN1 RPIA RPS6KA1 RUFY4 RUNDC3A RUVBL2 S100A3 S100B SAPCD1 SAT1 SCLT1 SCML1 SCML2 SCNM1 SDK1 SEPTIN1 SGF29 SH2D2A SHFL SHTN1 SLC6A15 SLC6A5 SNCB SNRNP25 SNRPA SNRPF SOCS6 SP4 SPG21 SPHKAP SRSF1 SRSF3 SSNA1 SSTR3 STAC2 STRN STX5 SUV39H1 SUV39H2 SYCE1L SYTL2 TACO1 TAX1BP1 TBC1D1 TBCEL TCF12 TCL1A TDO2 TEKT4 TFIP11 TGM7 THAP1 THAP7 THG1L TIFA TMEM132D TMEM14C TMEM239 TNFAIP1 TNFAIP3 TNFRSF18 TPM4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM10 TRIM14 TRIM21 TRIM23 TRIM27 TRIM3 TRIM39 TRIM42 TRIM50 TRIM54 TRIM60 TRIM68 TRIM8 TRIP13 TRIP6 TSC2 TSC22D4 TSG101 TSN TSPYL2 TSSK3 TYRO3 TYW2 UBASH3A UBE2D2 UBE2D4 UBP1 ULK2 UPP2 USP54 VASN VCP VMAC VPS37B VPS52 VRK2 WAC WDR25 WNT8A WWP1 YWHAZ ZBED1 ZBTB2 ZBTB24 ZBTB26 ZBTB43 ZBTB8A ZCCHC10 ZFP64 ZGPAT ZNF148 ZNF213 ZNF263 ZNF346 ZNF426 ZNF446 ZNF552 ZNF581 ZNF593 ZNF655 ZRANB1	14 interacting genes: BCCIP CAV1 CD4 CD44 FBXO21 HAX1 LNX1 MAPKAP1 MAPRE1 NEDD4 PIM1 PSMB8 RNF2 USP7
Entrez ID		84708	5243
HPRD ID		17287	01370
Ensembl ID		ENSG00000072201	ENSG00000085563
Uniprot IDs		Q8TBB1	A4D1D2 P08183
PDB IDs		3B76 5H7R 5H7S	6C0V 6FN1 6FN4 6QEX 7A65 7A69 7A6C 7A6E 7A6F 7O9W 8Y6H 8Y6I 9CR8 9CTC 9CTF 9CTG
GO Terms Enriched among Interactors		Identical Protein Binding Protein Binding Cytosol Cytoplasm Nucleus Spliceosomal Complex Regulation Of RNA Splicing Signaling Adaptor Activity Keratin Filament Intermediate Filament Protein Complex Oligomerization Negative Regulation Of Viral Transcription Thioesterase Binding Cellular Component Assembly CD40 Receptor Complex Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Viral Transcription MRNA Splicing, Via Spliceosome Type III Intermediate Filament Positive Regulation Of RNA Splicing Ubiquitin Protein Ligase Activity RNA Splicing, Via Transesterification Reactions Regulation Of Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Interleukin-17-mediated Signaling Pathway Protein Homooligomerization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Tumor Necrosis Factor Receptor Binding RNA Splicing Protein K63-linked Ubiquitination Negative Regulation Of Viral Process MRNA Processing Zinc Ion Binding Ubiquitin-protein Transferase Activity Cytoskeletal Anchor Activity Regulation Of Signal Transduction Nucleoplasm Regulation Of MRNA Processing	Cytokine-mediated Signaling Pathway Response To Nutrient Levels Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Intracellular Signal Transduction Cellular Response To Nutrient Levels Regulation Of Intracellular Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin Ligase Complex Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Signal Transduction Negative Regulation Of Potassium Ion Transmembrane Transport Proteolysis Involved In Protein Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Proteolysis Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Potassium Ion Transport Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cortex Regulation Of DNA-binding Transcription Factor Activity Mitotic Spindle Pole Establishment Of Mitotic Spindle Orientation Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Regulation Of Cellular Localization Inward Rectifier Potassium Channel Inhibitor Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Metabolic Process Formation Of Structure Involved In A Symbiotic Process Positive Regulation Of Cardioblast Proliferation Protein Localization To Astral Microtubule Regulation Of Protein Kinase Activity Protein Stabilization Maintenance Of Protein Location In Cell Establishment Of Spindle Localization Macromolecule Metabolic Process Regulation Of Signal Transduction