LNX2 and NUMB

Number of citations of the paper that reports this interaction (PMID 11782429)
19

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		LNX2	NUMB
Gene Name		ligand of numb-protein X 2	numb homolog (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Apical Part Of Cell
	Molecular Function	Protein Binding Zinc Ion Binding PDZ Domain Binding	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Protein Homooligomerization	Notch Signaling Pathway Axon Guidance Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Positive Regulation Of Polarized Epithelial Cell Differentiation Adherens Junction Organization Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Neurogenesis Lung Epithelial Cell Differentiation Negative Regulation Of Protein Localization To Plasma Membrane
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH L1CAM interactions Recycling pathway of L1 Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Degradation of GLI1 by the proteasome Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Large B-cell lymphoma ( 21471979)	Bipolar disorder (mood-incongruent) ( 23092984) Coronary artery calcification ( 17903303)
Protein-Protein Interactions		17 interactors: CBX4 CXADR HOXA1 IGSF5 LNX1 MDGA1 NUMB PDZRN3 PDZRN4 PKDREJ RLIM RNF138 SHISA2 UBE2I UBE2T UBE2Z USP2	24 interactors: AP2A1 AP2A2 APP DPYSL2 EGFR EPS15 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MDM2 NOTCH1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ RPL3 SIAH1
Entrez ID		222484	8650
HPRD ID		10042	04767
Ensembl ID		ENSG00000139517	ENSG00000133961
Uniprot IDs		Q8N448	P49757
PDB IDs		2VWR
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Sumoylation Cellular Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Optokinetic Behavior Abducens Nerve Formation Random Inactivation Of X Chromosome Positive Regulation Of SUMO Transferase Activity Protein Catabolic Process Facial Nucleus Development Positive Regulation Of Polarized Epithelial Cell Differentiation Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Rhombomere 4 Development Semicircular Canal Formation Cellular Macromolecule Catabolic Process Rhombomere 3 Development Rhombomere 5 Development Neuroblast Division In Subventricular Zone Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination AV Node Cell To Bundle Of His Cell Communication	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Blood Coagulation Hemostasis Response To Growth Factor Wound Healing Platelet Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Activation Response To Wounding Regulation Of Immune System Process Regulation Of Body Fluid Levels Immune System Process Cell Surface Receptor Signaling Pathway Response To External Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Locomotion Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Signaling Regulation Of Phospholipase Activity Chemotaxis Positive Regulation Of Lipase Activity Neuron Projection Morphogenesis Signal Transduction Cellular Response To Organic Substance Signaling Response To Organic Substance Axonogenesis Defense Response Activation Of Phospholipase C Activity Cell Communication Cellular Response To Stimulus Axon Development Neuron Projection Development Innate Immune Response Negative Regulation Of Signal Transduction Axon Guidance Positive Regulation Of Phospholipase C Activity Regulation Of Cellular Amino Acid Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Part Morphogenesis Negative Regulation Of Signaling Response To Stimulus
Tagcloud ?		amplicons aneuploidy behind candidates colorectal copy crc dis3 downregulated drivers gains gpr180 imbalances klf5 landscape mapping notch nupl1 offering oncogene polr1d pomp profiling rnai silencing slc7a1 tcf7l2 unfinished wnt	adapter affinities arise asymmetric bind bond contain diverse division domain gp gppy helical hydrogen ldnpay library lnx modes motif nak nmr npxy peptide phosphotyrosine ptb reveals sheet turn y
Tagcloud (Difference) ?		amplicons aneuploidy behind candidates colorectal copy crc dis3 downregulated drivers gains gpr180 imbalances klf5 landscape mapping notch nupl1 offering oncogene polr1d pomp profiling rnai silencing slc7a1 tcf7l2 unfinished wnt	adapter affinities arise asymmetric bind bond contain diverse division domain gp gppy helical hydrogen ldnpay library lnx modes motif nak nmr npxy peptide phosphotyrosine ptb reveals sheet turn y
Tagcloud (Intersection) ?