LNX1 and EHMT2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LNX1	EHMT2
Gene Name		ligand of numb-protein X 1, E3 ubiquitin protein ligase	euchromatic histone-lysine N-methyltransferase 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity PDZ Domain Binding	P53 Binding Protein Binding Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Homooligomerization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Replication DNA Methylation Chromatin Organization Histone Methylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Histone H3-K9 Methylation Histone H3-K27 Methylation
Pathways			Chromatin modifying enzymes Chromatin organization RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation PKMTs methylate histone lysines RNA Polymerase I Promoter Clearance Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS		DNA methylation (variation) ( 23725790)	Chronic hepatitis B infection ( 23760081) Economic and political preferences (environmentalism) ( 22566634) Epstein-Barr virus immune response (EBNA-1) ( 23326239)
Protein-Protein Interactions		218 interactors: ABCA1 ABCB1 ABR ACAT2 ACY3 ADRA1D AGTRAP AIDA AIMP2 AKIRIN2 ALDOC ALKBH3 AMMECR1L APIP APOL4 APP ARHGAP6 ARHGEF16 ARVCF ATPAF2 ATRIP AURKC BCR BLVRA BPIFA1 C1QTNF1 CA8 CALCOCO2 CAMK2N2 CATSPERD CCDC101 CCDC102B CCDC114 CCDC85B CDA CDC42EP4 CEP72 CGN CIB3 CIRBP CITED1 CLDN1 CLDN17 CLDN2 CLK2 COIL CPNE2 CTBP1 CTNND2 CTSO CUTC CXADR DAB1 DAPK1 DCTD DCUN1D5 DDX17 DEPTOR DNPEP DOCK9 DPF2 DVL3 EBF4 EHMT2 EIF4H ENOX1 EPHB3 EXOC8 FAM118A FAM124A FAM212B FAM9B FBP1 FBXL12 FHL3 GAS2L2 GDI1 GIPR GJD4 GOLPH3L GPR142 GRB2 GRIN1 HMBOX1 HOMEZ HSBP1 HTR2B HUNK IGSF5 IL3RA ILF3 INSC ISCU JOSD1 KALRN KCNA4 KCTD1 KCTD13 KCTD17 KCTD6 KHDRBS3 KIAA1598 KLHL12 KRT15 KRTAP4-12 KRTAP4-2 KRTAP9-2 KXD1 LCLAT1 LDOC1 LGALS14 LGR6 LNX2 LRRC3B LSM2 MAGEA11 MAGEB18 MAPK9 MEMO1 METTL21A MRFAP1L1 MRPS24 MTMR9 MTUS2 MUSTN1 MVB12B NADK NAGK NCK2 NECAB2 NEK6 NKD2 NME7 NOTCH2NL NRCAM NUDT14 NUMB NUP37 NXT2 ORMDL3 OSBP2 OSGIN1 PAFAH1B3 PAICS PBK PBLD PCBD1 PDZRN3 PDZRN4 PKDREJ PKM PKP4 POMGNT1 PPIA PPID PQBP1 PRR13 PTGIR PTS RABAC1 RAD51D RAD54B RBMX RBMY1A1 RFPL3 ROBO3 ROPN1 RPIA RUFY4 RUVBL2 SAPCD1 SAT1 SCLT1 SDK1 SLC6A15 SLC6A5 SNCB SNRNP25 SNRPF SPHKAP SRSF1 SSNA1 SSTR3 STAC2 STRN STX5 SUV39H1 SUV39H2 TBCEL THAP7 TIFA TMEM14C TNFRSF18 TPM4 TRAF2 TRIM23 TRIM39 TRIM54 TRIP13 TRMT12 TSC2 TSC22D4 TSSK3 TYRO3 UBE2D2 ULK2 VCP VRK2 WAC WNT8A WWP1 ZADH2 ZBTB43 ZBTB8A ZCCHC10 ZFP64 ZNF581 ZNF593	42 interactors: C10orf12 CACNA1A CBX1 CCDC33 CHCHD2 CUX1 DNMT3A E4F1 ESR1 FAM161A H3F3B HGS HIST1H1A HIST1H1B HIST1H3A HIST2H3A HIST2H3C HIST3H3 ITGB5 KLF12 KLF3 KLF6 LIMS1 LMO2 LNX1 MX2 NAA10 NAPRT PLOD3 PRRC2B PSMA1 RD3 RELB RERE RUVBL2 THAP7 TP53 WIZ XAGE2 ZBTB38 ZNF512B ZNF785
Entrez ID		84708	10919
HPRD ID		17287	06854
Ensembl ID		ENSG00000072201	ENSG00000204371
Uniprot IDs		Q8TBB1	A2ABF8 A2ABF9 Q96KQ7
PDB IDs		3B76	2O8J 3DM1 3K5K 3RJW
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Protein Homooligomerization Protein Oligomerization Protein Complex Assembly Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Regulation Of Cellular Component Organization Cellular Aromatic Compound Metabolic Process Regulation Of Rho Protein Signal Transduction Response To Stimulus Developmental Process Cellular Metabolic Process Peptidyl-lysine Dimethylation Heterocycle Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Neutrophil Degranulation Cellular Response To Stimulus Viral Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process Protein Tetramerization Cell Death Apoptotic Process Death Neuron Recognition Cell Communication Signaling Regulation Of Neutrophil Degranulation Negative Regulation Of Neutrophil Activation Viral Release From Host Cell Regulation Of Rho GTPase Activity Cell-cell Junction Organization Protein Autophosphorylation Response To Abiotic Stimulus Organelle Organization Regulation Of Cell Morphogenesis Nitrogen Compound Metabolic Process Axon Midline Choice Point Recognition Positive Regulation Of Rho GTPase Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Homodimerization Activity Regulation Of Ras Protein Signal Transduction Protein Heterooligomerization Biosynthetic Process	DNA Methylation On Cytosine Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Silencing Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Silencing At RDNA DNA Methylation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Conformation Change Regulation Of Metabolic Process Chromosome Organization DNA Modification DNA Packaging Transcription, DNA-templated Gene Silencing RNA Biosynthetic Process Chromatin Organization Chromatin Assembly Chromatin Assembly Or Disassembly Positive Regulation Of Gene Expression Cellular Component Assembly Regulation Of Gene Expression, Epigenetic DNA Metabolic Process Establishment Of Protein Localization To Chromatin RNA Metabolic Process Nucleosome Assembly Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleosome Organization Cellular Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Protein-DNA Complex Assembly Organelle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated
Tagcloud ?			availability biosensor bix01294 chaetocin codc enables expedite fluc2 g4s h3 h4 imaging k9 live lysine mark methylation methylations methyltransferase monitor nude pace preclinical replacement reveals sensor suv39h1 treating utility
Tagcloud (Difference) ?			availability biosensor bix01294 chaetocin codc enables expedite fluc2 g4s h3 h4 imaging k9 live lysine mark methylation methylations methyltransferase monitor nude pace preclinical replacement reveals sensor suv39h1 treating utility
Tagcloud (Intersection) ?