LNX2 and MDGA1

Number of citations of the paper that reports this interaction (PubMedID 22889411)
0

Data Source:
BioGRID (two hybrid)

		LNX2	MDGA1
Description		ligand of numb-protein X 2	MAM domain containing glycosylphosphatidylinositol anchor 1
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GO Annotations	Cellular Component	Plasma Membrane	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Cell Surface Membrane Axon Dendrite Side Of Membrane GABA-ergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Nervous System Development Neuron Differentiation Neural Precursor Cell Proliferation	Neuron Migration Nervous System Development Brain Development Spinal Cord Association Neuron Differentiation Cerebral Cortex Radially Oriented Cell Migration Cell Differentiation Dopamine Metabolic Process Serotonin Metabolic Process Prepulse Inhibition Presynapse Assembly Regulation Of Synaptic Membrane Adhesion Inhibitory Synapse Assembly Regulation Of Presynapse Assembly
Pathways			Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 27863252 32888494) Night sleep phenotypes ( 27126917) Platelet distribution width ( 27863252 32888494) Response to cytadine analogues (cytosine arabinoside) ( 24483146)	Acne (severe) ( 24927181) Chronotype ( 30696823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Daytime nap ( 33568662) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Lamb consumption ( 32066663) Neurological blood protein biomarker levels ( 31320639) Restless legs syndrome ( 29029846)
Interacting Genes		90 interacting genes: ATP5F1B C10orf88 CABP4 CBX4 CCT3 CDK2 CDK4 CDKN2C CRK CXADR DDA1 DRAP1 EAF2 FANCG FHL3 GADD45A GJD2 GLRX3 GRAP2 GRB2 IGSF5 IL16 INMT IP6K2 L3MBTL2 LGALS14 LNX1 LRRC8E MAP2K5 MAPK9 MCM7 MDGA1 MECOM MLX MRFAP1L1 MSRB3 MYLIP NAGK NMD3 NOTCH1 NTAQ1 NUDT14 NUMB OPTN PARVG PDZRN3 PDZRN4 PEG10 PHYKPL PIK3R1 PIK3R3 PKDREJ POLR1C PPIH PPIL1 PSMD5 PSMF1 PTCD3 RAB6B RBM17 RLIM RNF138 ROPN1 RPA2 SCLY SCNM1 SFN SH3GLB2 SHISA2 SHTN1 SMARCB1 SRSF11 TAB1 TBC1D7 TCL1A TIFA TRAF1 TRAF2 TUBB UBE2D2 UBE2H UBE2I UBE2T UBE2Z USP2 VTN YJU2 ZNF148 ZNF410 ZNF581	2 interacting genes: LNX2 NLGN2
Entrez ID		222484	266727
HPRD ID		10042	14374
Ensembl ID		ENSG00000139517	ENSG00000112139
Uniprot IDs		Q8N448	A0A7P0TB62 Q8NFP4
PDB IDs		2VWR 5DIN 5E11 5E1Y 5E21 5E22 7QCT	5V5V 5V5W 5XEQ
Enriched GO Terms of Interacting Partners?		Nucleoplasm Phosphotyrosine Residue Binding Post-translational Protein Modification Nucleus Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Cytosol Ubiquitin-protein Transferase Activity Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Nuclear Speck Protein Ubiquitination Identical Protein Binding Response To Nitric Oxide Transferase Activity Cytoplasm	Positive Regulation Of T-SNARE Clustering Jump Response Glycinergic Synapse Ribbon Synapse Postsynaptic Membrane Assembly Terminal Button Organization Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Vesicle Clustering Modulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Inhibitory Postsynaptic Potential Symmetric, GABA-ergic, Inhibitory Synapse Positive Regulation Of Protein Localization To Synapse Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Synaptic Vesicle Clustering Thigmotaxis Neuron To Neuron Synapse Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neurexin Family Protein Binding Regulation Of Respiratory Gaseous Exchange By Nervous System Process Dopaminergic Synapse Locomotory Exploration Behavior Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Inhibitory Synapse Neurotransmitter-gated Ion Channel Clustering Presynapse Assembly Presynaptic Membrane Organization Postsynaptic Specialization Assembly Positive Regulation Of Synaptic Transmission, GABAergic Insulin Metabolic Process Presynapse Organization Cell-cell Junction Maintenance Regulation Of Respiratory Gaseous Exchange Inhibitory Synapse Assembly Postsynaptic Specialization Organization Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Regulation Of Protein Localization To Synapse Excitatory Synapse Protein Localization To Cell Surface Postsynaptic Specialization Membrane Positive Regulation Of Excitatory Postsynaptic Potential Synaptic Transmission, GABAergic Exploration Behavior Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Dendritic Spine Development Dendritic Shaft Sensory Perception Of Pain
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