LNX2 and RLIM

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		LNX2	RLIM
Description		ligand of numb-protein X 2	ring finger protein, LIM domain interacting
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GO Annotations	Cellular Component	Plasma Membrane	Nucleus Nucleoplasm Cytosol Transcription Repressor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nervous System Development Neuron Differentiation Neural Precursor Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of DNA-templated Transcription Random Inactivation Of X Chromosome
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 27863252 32888494) Night sleep phenotypes ( 27126917) Platelet distribution width ( 27863252 32888494) Response to cytadine analogues (cytosine arabinoside) ( 24483146)	Brain asymmetrical skew (horizontal) ( 33836062)
Interacting Genes		90 interacting genes: ATP5F1B C10orf88 CABP4 CBX4 CCT3 CDK2 CDK4 CDKN2C CRK CXADR DDA1 DRAP1 EAF2 FANCG FHL3 GADD45A GJD2 GLRX3 GRAP2 GRB2 IGSF5 IL16 INMT IP6K2 L3MBTL2 LGALS14 LNX1 LRRC8E MAP2K5 MAPK9 MCM7 MDGA1 MECOM MLX MRFAP1L1 MSRB3 MYLIP NAGK NMD3 NOTCH1 NTAQ1 NUDT14 NUMB OPTN PARVG PDZRN3 PDZRN4 PEG10 PHYKPL PIK3R1 PIK3R3 PKDREJ POLR1C PPIH PPIL1 PSMD5 PSMF1 PTCD3 RAB6B RBM17 RLIM RNF138 ROPN1 RPA2 SCLY SCNM1 SFN SH3GLB2 SHISA2 SHTN1 SMARCB1 SRSF11 TAB1 TBC1D7 TCL1A TIFA TRAF1 TRAF2 TUBB UBE2D2 UBE2H UBE2I UBE2T UBE2Z USP2 VTN YJU2 ZNF148 ZNF410 ZNF581	31 interacting genes: BRF1 CDK2 CFLAR ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LMO4 LNX2 MDM2 PDLIM1 REXO1 SIN3A SMURF2 SNX17 SS18L1 STAT6 TERF1 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2K
Entrez ID		222484	51132
HPRD ID		10042	02304
Ensembl ID		ENSG00000139517	ENSG00000131263
Uniprot IDs		Q8N448	Q9NVW2
PDB IDs		2VWR 5DIN 5E11 5E1Y 5E21 5E22 7QCT	6W7Z 6W9A 6W9D
Enriched GO Terms of Interacting Partners?		Nucleoplasm Phosphotyrosine Residue Binding Post-translational Protein Modification Nucleus Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Cytosol Ubiquitin-protein Transferase Activity Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Nuclear Speck Protein Ubiquitination Identical Protein Binding Response To Nitric Oxide Transferase Activity Cytoplasm	Transcription Regulator Complex Ubiquitin-protein Transferase Activity Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process LIM Domain Binding Spinal Cord Motor Neuron Cell Fate Specification Central Nervous System Neuron Differentiation Neuron Differentiation Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Cell Differentiation In Spinal Cord Spinal Cord Association Neuron Differentiation Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Motor Neuron Axon Guidance Regulation Of Gene Expression Neuron Fate Specification
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