LNX1 and TYRO3

Number of citations of the paper that reports this interaction (PMID 22889411)
1

Data Source:
BioGRID (two hybrid)

		LNX1	TYRO3
Gene Name		ligand of numb-protein X 1, E3 ubiquitin protein ligase	TYRO3 protein tyrosine kinase
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Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity PDZ Domain Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Homooligomerization	Natural Killer Cell Differentiation Cell Adhesion Signal Transduction Spermatogenesis Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Signal Transduction By Phosphorylation Platelet Activation Secretion By Cell Negative Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Innate Immune Response Protein Autophosphorylation Negative Regulation Of Inflammatory Response Negative Regulation Of Lymphocyte Activation Vagina Development Neuron Cellular Homeostasis Platelet Aggregation
Pathways
Drugs
Diseases
GWAS		DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		218 interactors: ABCA1 ABCB1 ABR ACAT2 ACY3 ADRA1D AGTRAP AIDA AIMP2 AKIRIN2 ALDOC ALKBH3 AMMECR1L APIP APOL4 APP ARHGAP6 ARHGEF16 ARVCF ATPAF2 ATRIP AURKC BCR BLVRA BPIFA1 C1QTNF1 CA8 CALCOCO2 CAMK2N2 CATSPERD CCDC101 CCDC102B CCDC114 CCDC85B CDA CDC42EP4 CEP72 CGN CIB3 CIRBP CITED1 CLDN1 CLDN17 CLDN2 CLK2 COIL CPNE2 CTBP1 CTNND2 CTSO CUTC CXADR DAB1 DAPK1 DCTD DCUN1D5 DDX17 DEPTOR DNPEP DOCK9 DPF2 DVL3 EBF4 EHMT2 EIF4H ENOX1 EPHB3 EXOC8 FAM118A FAM124A FAM212B FAM9B FBP1 FBXL12 FHL3 GAS2L2 GDI1 GIPR GJD4 GOLPH3L GPR142 GRB2 GRIN1 HMBOX1 HOMEZ HSBP1 HTR2B HUNK IGSF5 IL3RA ILF3 INSC ISCU JOSD1 KALRN KCNA4 KCTD1 KCTD13 KCTD17 KCTD6 KHDRBS3 KIAA1598 KLHL12 KRT15 KRTAP4-12 KRTAP4-2 KRTAP9-2 KXD1 LCLAT1 LDOC1 LGALS14 LGR6 LNX2 LRRC3B LSM2 MAGEA11 MAGEB18 MAPK9 MEMO1 METTL21A MRFAP1L1 MRPS24 MTMR9 MTUS2 MUSTN1 MVB12B NADK NAGK NCK2 NECAB2 NEK6 NKD2 NME7 NOTCH2NL NRCAM NUDT14 NUMB NUP37 NXT2 ORMDL3 OSBP2 OSGIN1 PAFAH1B3 PAICS PBK PBLD PCBD1 PDZRN3 PDZRN4 PKDREJ PKM PKP4 POMGNT1 PPIA PPID PQBP1 PRR13 PTGIR PTS RABAC1 RAD51D RAD54B RBMX RBMY1A1 RFPL3 ROBO3 ROPN1 RPIA RUFY4 RUVBL2 SAPCD1 SAT1 SCLT1 SDK1 SLC6A15 SLC6A5 SNCB SNRNP25 SNRPF SPHKAP SRSF1 SSNA1 SSTR3 STAC2 STRN STX5 SUV39H1 SUV39H2 TBCEL THAP7 TIFA TMEM14C TNFRSF18 TPM4 TRAF2 TRIM23 TRIM39 TRIM54 TRIP13 TRMT12 TSC2 TSC22D4 TSSK3 TYRO3 UBE2D2 ULK2 VCP VRK2 WAC WNT8A WWP1 ZADH2 ZBTB43 ZBTB8A ZCCHC10 ZFP64 ZNF581 ZNF593	20 interactors: A2M APOE AXL FYN GAS6 IKBKG KLK4 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 LNX1 MDFI PIK3R1 PROS1 SRC YES1
Entrez ID		84708	7301
HPRD ID		17287	02641
Ensembl ID		ENSG00000072201	ENSG00000092445
Uniprot IDs		Q8TBB1	Q06418
PDB IDs		3B76	1RHF
Enriched GO Terms of Interacting Partners?		Cellular Component Assembly Protein Homooligomerization Protein Oligomerization Protein Complex Assembly Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Regulation Of Cellular Component Organization Cellular Aromatic Compound Metabolic Process Regulation Of Rho Protein Signal Transduction Response To Stimulus Developmental Process Cellular Metabolic Process Peptidyl-lysine Dimethylation Heterocycle Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Neutrophil Degranulation Cellular Response To Stimulus Viral Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process Protein Tetramerization Cell Death Apoptotic Process Death Neuron Recognition Cell Communication Signaling Regulation Of Neutrophil Degranulation Negative Regulation Of Neutrophil Activation Viral Release From Host Cell Regulation Of Rho GTPase Activity Cell-cell Junction Organization Protein Autophosphorylation Response To Abiotic Stimulus Organelle Organization Regulation Of Cell Morphogenesis Nitrogen Compound Metabolic Process Axon Midline Choice Point Recognition Positive Regulation Of Rho GTPase Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Homodimerization Activity Regulation Of Ras Protein Signal Transduction Protein Heterooligomerization Biosynthetic Process	Platelet Activation Blood Coagulation Response To Wounding Hemostasis Regulation Of Body Fluid Levels Wound Healing Leukocyte Migration Regulation Of Cell Activation Phagocytosis Regulation Of Immune System Process Positive Regulation Of Cell Activation Vesicle-mediated Transport Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Endocytosis Cell Activation Regulation Of Lymphocyte Activation T Cell Costimulation Innate Immune Response Response To Stress Intracellular Signal Transduction Cell Migration Immune Response Regulation Of Immune Response Cell Motility Negative Regulation Of Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune System Process Negative Regulation Of Programmed Cell Death Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Response To Growth Factor Negative Regulation Of Dendritic Cell Apoptotic Process Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Locomotion Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization To Nucleus Response To Peptide Hormone Defense Response Negative Regulation Of Neuron Death
Tagcloud ?			anticoagulant ark axl brt called chinese composed ectopically eyk fc fused g1 gas6 hamster immunoglobulin ligand maximal member mer native ovary rse sky specifically stimulates structurally subfamily tyrosine ufo
Tagcloud (Difference) ?			anticoagulant ark axl brt called chinese composed ectopically eyk fc fused g1 gas6 hamster immunoglobulin ligand maximal member mer native ovary rse sky specifically stimulates structurally subfamily tyrosine ufo
Tagcloud (Intersection) ?