LNX2 and UBE2T

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		LNX2	UBE2T
Description		ligand of numb-protein X 2	ubiquitin conjugating enzyme E2 T
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GO Annotations	Cellular Component	Plasma Membrane	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Nervous System Development Neuron Differentiation Neural Precursor Cell Proliferation	Protein Polyubiquitination DNA Repair Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways			Fanconi Anemia Pathway Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 27863252 32888494) Night sleep phenotypes ( 27126917) Platelet distribution width ( 27863252 32888494) Response to cytadine analogues (cytosine arabinoside) ( 24483146)	Breast cancer ( 23535733) Celiac disease ( 23936387)
Interacting Genes		90 interacting genes: ATP5F1B C10orf88 CABP4 CBX4 CCT3 CDK2 CDK4 CDKN2C CRK CXADR DDA1 DRAP1 EAF2 FANCG FHL3 GADD45A GJD2 GLRX3 GRAP2 GRB2 IGSF5 IL16 INMT IP6K2 L3MBTL2 LGALS14 LNX1 LRRC8E MAP2K5 MAPK9 MCM7 MDGA1 MECOM MLX MRFAP1L1 MSRB3 MYLIP NAGK NMD3 NOTCH1 NTAQ1 NUDT14 NUMB OPTN PARVG PDZRN3 PDZRN4 PEG10 PHYKPL PIK3R1 PIK3R3 PKDREJ POLR1C PPIH PPIL1 PSMD5 PSMF1 PTCD3 RAB6B RBM17 RLIM RNF138 ROPN1 RPA2 SCLY SCNM1 SFN SH3GLB2 SHISA2 SHTN1 SMARCB1 SRSF11 TAB1 TBC1D7 TCL1A TIFA TRAF1 TRAF2 TUBB UBE2D2 UBE2H UBE2I UBE2T UBE2Z USP2 VTN YJU2 ZNF148 ZNF410 ZNF581	25 interacting genes: AMFR ARIH2 BRCA1 CDK2 CHEK1 FANCD2 FANCL LNX2 MARCHF5 MGRN1 PCGF2 PRKCG PRKN RNF128 RNF144B RNF167 RNF31 RNF4 ROCK1 RPS6KA1 TRIM27 UBA1 UBA6 UBC ZNRF2
Entrez ID		222484	29089
HPRD ID		10042	13704
Ensembl ID		ENSG00000139517	ENSG00000077152
Uniprot IDs		Q8N448	Q9NPD8
PDB IDs		2VWR 5DIN 5E11 5E1Y 5E21 5E22 7QCT	1YH2 4CCG 5NGZ 5OJJ 6R75 7KZR 7KZS 7KZT 7KZV 8JUC 8JVD 8JVE 8JVL
Enriched GO Terms of Interacting Partners?		Nucleoplasm Phosphotyrosine Residue Binding Post-translational Protein Modification Nucleus Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Cytosol Ubiquitin-protein Transferase Activity Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Nuclear Speck Protein Ubiquitination Identical Protein Binding Response To Nitric Oxide Transferase Activity Cytoplasm	Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Transferase Activity Protein Polyubiquitination Protein Metabolic Process Zinc Ion Binding Metal Ion Binding Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Autoubiquitination Protein K6-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Response To Stress Cellular Response To Stress Protein K27-linked Ubiquitination Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Cytosol Ubiquitin Activating Enzyme Activity DNA Damage Response DNA Damage Checkpoint Signaling Ubiquitin Conjugating Enzyme Binding Condensed Chromosome Negative Regulation Of Programmed Cell Death Regulation Of Organelle Organization Catabolic Process Regulation Of Protein Targeting To Mitochondrion Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Protein Monoubiquitination Cytoplasm Ubiquitin-like Modifier Activating Enzyme Activity Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Autophagy Negative Regulation Of Cell Cycle Protein Serine Kinase Activity Protein K29-linked Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling
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