LNX2 and CBX4

Number of citations of the paper that reports this interaction (PMID 22889411)
1

Data Source:
BioGRID (two hybrid)

		LNX2	CBX4
Gene Name		ligand of numb-protein X 2	chromobox homolog 4
Image
Gene Ontology Annotations	Cellular Component		Nucleus Nucleoplasm Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Zinc Ion Binding PDZ Domain Binding	Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding Ligase Activity Enzyme Binding SUMO Binding Methylated Histone Binding Transcription Regulatory Region DNA Binding Phosphoprotein Binding
	Biological Process	Protein Homooligomerization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Chromatin Modification Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Large B-cell lymphoma ( 21471979)
Protein-Protein Interactions		17 interactors: CBX4 CXADR HOXA1 IGSF5 LNX1 MDGA1 NUMB PDZRN3 PDZRN4 PKDREJ RLIM RNF138 SHISA2 UBE2I UBE2T UBE2Z USP2	18 interactors: CBS CSNK2B CTBP1 CTBP2 FHL1 HIST3H3 KMT2A LNX2 MBD1 MED9 RB1 RING1 RNF2 SATB1 SKIL SUV39H1 UBE2I ZEB2
Entrez ID		222484	8535
HPRD ID		10042	04357
Ensembl ID		ENSG00000139517	ENSG00000141582
Uniprot IDs		Q8N448	O00257
PDB IDs		2VWR	2K28 3I8Z
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Sumoylation Cellular Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Optokinetic Behavior Abducens Nerve Formation Random Inactivation Of X Chromosome Positive Regulation Of SUMO Transferase Activity Protein Catabolic Process Facial Nucleus Development Positive Regulation Of Polarized Epithelial Cell Differentiation Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Rhombomere 4 Development Semicircular Canal Formation Cellular Macromolecule Catabolic Process Rhombomere 3 Development Rhombomere 5 Development Neuroblast Division In Subventricular Zone Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination AV Node Cell To Bundle Of His Cell Communication	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Chromatin Modification Histone Modification RNA Metabolic Process Chromosome Organization Cellular Nitrogen Compound Metabolic Process Chromatin Organization Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Histone H2A Monoubiquitination Anterior/posterior Pattern Specification Histone H2A Ubiquitination Cellular Metabolic Process Regulation Of Metabolic Process White Fat Cell Differentiation Developmental Process Histone Methylation Histone Monoubiquitination Negative Regulation Of Cell Proliferation Viral Genome Replication Organelle Organization Peptidyl-lysine Trimethylation Protein Methylation Histone Ubiquitination Cell Cycle Cell Differentiation Pattern Specification Process
Tagcloud ?		amplicons aneuploidy behind candidates colorectal copy crc dis3 downregulated drivers gains gpr180 imbalances klf5 landscape mapping notch nupl1 offering oncogene polr1d pomp profiling rnai silencing slc7a1 tcf7l2 unfinished wnt	3p accordingly bodies brachyury cbx7 chemicals ectodermal embryoid endodermal fgf5 foxa2 ideal markers meanwhile mebs mesodermal nanog nestin oct4 pcg perfluorooctane pfos pluripotency polycomb poses sma sox17 sox2 sulfonate
Tagcloud (Difference) ?		amplicons aneuploidy behind candidates colorectal copy crc dis3 downregulated drivers gains gpr180 imbalances klf5 landscape mapping notch nupl1 offering oncogene polr1d pomp profiling rnai silencing slc7a1 tcf7l2 unfinished wnt	3p accordingly bodies brachyury cbx7 chemicals ectodermal embryoid endodermal fgf5 foxa2 ideal markers meanwhile mebs mesodermal nanog nestin oct4 pcg perfluorooctane pfos pluripotency polycomb poses sma sox17 sox2 sulfonate
Tagcloud (Intersection) ?