LNX1 and PDE3B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LNX1	PDE3B
Description		ligand of numb-protein X 1	phosphodiesterase 3B
Image
GO Annotations	Cellular Component	Cytoplasm Hippocampal Mossy Fiber To CA3 Synapse Postsynapse	Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity PDZ Domain Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase B Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Nervous System Development Protein Ubiquitination Synapse Maturation	Angiogenesis Negative Regulation Of Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Angiogenesis Negative Regulation Of Lipid Catabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	PDE3B signalling PDE3B signalling G alpha (s) signalling events
Drugs			Caffeine Caffeine Papaverine Amrinone 6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Beard thickness ( 26926045) Cervical artery dissection ( 25420145) DNA methylation (variation) ( 23725790) Heel bone mineral density ( 30598549) Height ( 28552196) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Uterine fibroids ( 30194396 31649266)	Adiponectin levels ( 31178129) Bipolar disorder ( 31043756) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol ( 30275531) High density lipoprotein cholesterol levels ( 29083408) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum 25-Hydroxyvitamin D levels ( 31841498) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		476 interacting genes: ABCA1 ABCB1 ABI2 ABR ACAT2 ACTN1 ACTN3 ACTN4 ACY3 ADAMTSL4 ADRA1D AGTRAP AIDA AIMP2 AKIRIN2 ALDOC ALKBH3 AMMECR1L ANKS1A AP1M1 APIP APOL4 APP ARF3 ARFIP2 ARHGAP6 ARHGEF16 ARVCF ATPAF2 ATRIP AURKB AURKC AXIN2 BCR BEND7 BICD2 BIRC2 BLVRA BLZF1 BORCS6 BPIFA1 BTBD1 C10orf88 C1QTNF1 CA8 CABP5 CADPS CALCOCO2 CAMK2N2 CARD9 CASP6 CATSPERD CBX1 CBY1 CBY2 CCBE1 CCDC102B CCDC33 CCDC85B CCDC88B CCDC91 CCNDBP1 CDA CDC42EP4 CDIPT CDKN2D CEP70 CEP72 CEP76 CEP85 CGN CIB3 CIRBP CITED1 CLDN1 CLDN17 CLDN2 CLK1 CLK2 CLK3 CMTM5 COIL CPNE2 CPSF7 CRACR2B CRX CTBP1 CTNND2 CTSO CUTC CXADR CYSLTR2 CYSRT1 DAB1 DAPK1 DCTD DCTPP1 DCUN1D5 DDIT3 DDX17 DENND1B DEPTOR DERL1 DEUP1 DHPS DMC1 DNPEP DOCK9 DPF2 DRAP1 DRG1 DSCAM DTX2 DUSP29 DVL3 DYDC1 DYNLT1 EBF4 EDC3 EEF2KMT EFEMP2 EFHC2 EGLN3 EHMT2 EIF1AD EIF4A3 EIF4H ENOX1 ENOX2 EPHB3 EPM2AIP1 EVI5L EXOC8 EXOSC1 EXOSC4 EXOSC8 FAM118A FAM124A FAM90A1 FAM9B FASN FBP1 FBXL12 FHL3 FOXP2 FSD2 FXR1 GAS2L2 GDI1 GIPR GJD2 GJD4 GLRX3 GMCL1 GMNN GOLPH3L GPKOW GPR142 GRAP2 GRB2 GRIN1 GRIPAP1 GUCD1 HDX HEXIM2 HIP1 HMBOX1 HMG20A HNRNPF HNRNPH1 HOMER3 HOMEZ HOOK2 HOXA1 HSBP1 HSF2BP HTR2B HUNK IGSF5 IHO1 IKZF3 IL16 IL3RA ILF3 INKA2 INO80E INSC IP6K3 ISCU JAK3 JOSD1 KALRN KATNAL2 KCNA4 KCTD1 KCTD13 KCTD17 KCTD6 KCTD7 KCTD9 KHDRBS2 KHDRBS3 KIAA1328 KIF24 KIFC3 KLHL12 KPRP KRT15 KRT16 KRT40 KRTAP1-1 KRTAP10-8 KRTAP12-3 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 KXD1 LCLAT1 LCP2 LDB2 LDOC1 LEPROTL1 LGALS14 LGR6 LHX2 LNX2 LONRF1 LRRC3B LRRC73 LSM2 LUZP4 LZTS1 MAD1L1 MAGEA11 MAGEB18 MAPK9 MAPRE2 MEMO1 MEOX2 METTL21A MID2 MLX MRFAP1L1 MRPS24 MRPS6 MSANTD4 MSC MTMR9 MTUS2 MUSTN1 MVB12B MYEF2 NAB2 NADK NAGK NBPF19 NCK2 NDC80 NDOR1 NDUFAB1 NECAB1 NECAB2 NEK6 NKD2 NME1 NME7 NOTCH2NLA NRCAM NUDT14 NUMB NUP37 NUP62 NXT2 ODAD1 ORMDL1 ORMDL3 OSBP2 OSBPL3 OSGIN1 PAFAH1B3 PAICS PAK5 PBK PBLD PCBD1 PDE3B PDZRN3 PDZRN4 PFDN5 PKDREJ PKM PKP4 PLEKHA2 PNMA1 PNMA3 PNMA5 PNMT POMGNT1 POU6F2 PPIA PPID PPIH PPP1R13B PQBP1 PRDM14 PRKAR1B PRKRA PRMT5 PRPH PRR13 PRTFDC1 PSMC1 PSME2 PSME3 PSMF1 PTGIR PTGR3 PTPN11 PTS PURB QARS1 RAB33A RABAC1 RABIF RAD51D RAD54B RALY RASL11B RBAK RBCK1 RBM20 RBMX RBMY1A1 RBMY1F RBMY1J REEP6 RFPL3 RGS20 RIOX2 ROBO3 ROPN1 RPIA RPS6KA1 RUFY4 RUNDC3A RUVBL2 S100A3 S100B SAPCD1 SAT1 SCLT1 SCML1 SCML2 SCNM1 SDK1 SEPTIN1 SGF29 SH2D2A SHFL SHTN1 SLC6A15 SLC6A5 SNCB SNRNP25 SNRPA SNRPF SOCS6 SP4 SPG21 SPHKAP SRSF1 SRSF3 SSNA1 SSTR3 STAC2 STRN STX5 SUV39H1 SUV39H2 SYCE1L SYTL2 TACO1 TAX1BP1 TBC1D1 TBCEL TCF12 TCL1A TDO2 TEKT4 TFIP11 TGM7 THAP1 THAP7 THG1L TIFA TMEM132D TMEM14C TMEM239 TNFAIP1 TNFAIP3 TNFRSF18 TPM4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM10 TRIM14 TRIM21 TRIM23 TRIM27 TRIM3 TRIM39 TRIM42 TRIM50 TRIM54 TRIM60 TRIM68 TRIM8 TRIP13 TRIP6 TSC2 TSC22D4 TSG101 TSN TSPYL2 TSSK3 TYRO3 TYW2 UBASH3A UBE2D2 UBE2D4 UBP1 ULK2 UPP2 USP54 VASN VCP VMAC VPS37B VPS52 VRK2 WAC WDR25 WNT8A WWP1 YWHAZ ZBED1 ZBTB2 ZBTB24 ZBTB26 ZBTB43 ZBTB8A ZCCHC10 ZFP64 ZGPAT ZNF148 ZNF213 ZNF263 ZNF346 ZNF426 ZNF446 ZNF552 ZNF581 ZNF593 ZNF655 ZRANB1	7 interacting genes: AKT1 ANKRA2 HPGDS LNX1 PRKACA YWHAB YWHAQ
Entrez ID		84708	5140
HPRD ID		17287	03626
Ensembl ID		ENSG00000072201	ENSG00000152270
Uniprot IDs		Q8TBB1	A7E2E5 Q13370
PDB IDs		3B76 5H7R 5H7S	1SO2 1SOJ 8SYC
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Cytosol Cytoplasm Nucleus Spliceosomal Complex Regulation Of RNA Splicing Signaling Adaptor Activity Keratin Filament Intermediate Filament Protein Complex Oligomerization Negative Regulation Of Viral Transcription Thioesterase Binding Cellular Component Assembly CD40 Receptor Complex Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Viral Transcription MRNA Splicing, Via Spliceosome Type III Intermediate Filament Positive Regulation Of RNA Splicing Ubiquitin Protein Ligase Activity RNA Splicing, Via Transesterification Reactions Regulation Of Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Interleukin-17-mediated Signaling Pathway Protein Homooligomerization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Tumor Necrosis Factor Receptor Binding RNA Splicing Protein K63-linked Ubiquitination Negative Regulation Of Viral Process MRNA Processing Zinc Ion Binding Ubiquitin-protein Transferase Activity Cytoskeletal Anchor Activity Regulation Of Signal Transduction Nucleoplasm Regulation Of MRNA Processing	Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Vascular Endothelial Cell Response To Fluid Shear Stress Response To Laminar Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Cholesterol Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Postsynapse Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Fluid Shear Stress 14-3-3 Protein Binding Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Protein Domain Specific Binding Peptidyl-serine Phosphorylation Protein-containing Complex Positive Regulation Of Steroid Metabolic Process Response To Fluid Shear Stress Positive Regulation Of Glucose Metabolic Process Regulation Of Cholesterol Metabolic Process Regulation Of Protein Maturation TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of TRNA Methylation Regulation Of Monoatomic Ion Transport Regulation Of Steroid Biosynthetic Process TOR Signaling Negative Regulation Of Transport Response To Heat Negative Regulation Of TOR Signaling Protein Kinase Binding Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Cellular Localization Establishment Of Protein Localization Response To Insulin-like Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mammalian Oogenesis Stage Negative Regulation Of Small Molecule Metabolic Process TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Transmembrane Transport Regulation Of Nucleocytoplasmic Transport
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