LNX2 and PHYKPL

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid)

		LNX2	PHYKPL
Description		ligand of numb-protein X 2	5-phosphohydroxy-L-lysine phospho-lyase
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding	Protein Binding Transaminase Activity Lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Nervous System Development Neuron Differentiation Neural Precursor Cell Proliferation
Pathways			Collagen degradation Lysine catabolism
Drugs			Pyridoxal phosphate Alanine
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 27863252 32888494) Night sleep phenotypes ( 27126917) Platelet distribution width ( 27863252 32888494) Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		90 interacting genes: ATP5F1B C10orf88 CABP4 CBX4 CCT3 CDK2 CDK4 CDKN2C CRK CXADR DDA1 DRAP1 EAF2 FANCG FHL3 GADD45A GJD2 GLRX3 GRAP2 GRB2 IGSF5 IL16 INMT IP6K2 L3MBTL2 LGALS14 LNX1 LRRC8E MAP2K5 MAPK9 MCM7 MDGA1 MECOM MLX MRFAP1L1 MSRB3 MYLIP NAGK NMD3 NOTCH1 NTAQ1 NUDT14 NUMB OPTN PARVG PDZRN3 PDZRN4 PEG10 PHYKPL PIK3R1 PIK3R3 PKDREJ POLR1C PPIH PPIL1 PSMD5 PSMF1 PTCD3 RAB6B RBM17 RLIM RNF138 ROPN1 RPA2 SCLY SCNM1 SFN SH3GLB2 SHISA2 SHTN1 SMARCB1 SRSF11 TAB1 TBC1D7 TCL1A TIFA TRAF1 TRAF2 TUBB UBE2D2 UBE2H UBE2I UBE2T UBE2Z USP2 VTN YJU2 ZNF148 ZNF410 ZNF581	4 interacting genes: LNX2 POT1 USO1 VAC14
Entrez ID		222484	85007
HPRD ID		10042	18482
Ensembl ID		ENSG00000139517	ENSG00000175309
Uniprot IDs		Q8N448	Q8IUZ5
PDB IDs		2VWR 5DIN 5E11 5E1Y 5E21 5E22 7QCT
Enriched GO Terms of Interacting Partners?		Nucleoplasm Phosphotyrosine Residue Binding Post-translational Protein Modification Nucleus Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Cytosol Ubiquitin-protein Transferase Activity Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Nuclear Speck Protein Ubiquitination Identical Protein Binding Response To Nitric Oxide Transferase Activity Cytoplasm	Golgi Vesicle Docking Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding PAS Complex Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding Vesicle Fusion With Golgi Apparatus Telomerase Inhibitor Activity Shelterin Complex Establishment Of Protein Localization To Telomere DEAD/H-box RNA Helicase Binding Presynaptic Endosome Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Regulation Of DNA Strand Elongation Transcytosis Secretory Granule Localization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Golgi Membrane Golgi Stack Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process
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