LNX2 and PDZRN3

Number of citations of the paper that reports this interaction (PubMedID 22889411)
0

Data Source:
BioGRID (two hybrid)

		LNX2	PDZRN3
Description		ligand of numb-protein X 2	PDZ domain containing ring finger 3
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GO Annotations	Cellular Component	Plasma Membrane	Cytoplasm Neuromuscular Junction Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nervous System Development Neuron Differentiation Neural Precursor Cell Proliferation	Neuromuscular Junction Development Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 27863252 32888494) Night sleep phenotypes ( 27126917) Platelet distribution width ( 27863252 32888494) Response to cytadine analogues (cytosine arabinoside) ( 24483146)	Dialysis-related mortality ( 21546767) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Mercury levels ( 26025379) Mitochondrial DNA copy number (white blood cells) ( 30704525) PR interval ( 30046033 30679814 32439900)
Interacting Genes		90 interacting genes: ATP5F1B C10orf88 CABP4 CBX4 CCT3 CDK2 CDK4 CDKN2C CRK CXADR DDA1 DRAP1 EAF2 FANCG FHL3 GADD45A GJD2 GLRX3 GRAP2 GRB2 IGSF5 IL16 INMT IP6K2 L3MBTL2 LGALS14 LNX1 LRRC8E MAP2K5 MAPK9 MCM7 MDGA1 MECOM MLX MRFAP1L1 MSRB3 MYLIP NAGK NMD3 NOTCH1 NTAQ1 NUDT14 NUMB OPTN PARVG PDZRN3 PDZRN4 PEG10 PHYKPL PIK3R1 PIK3R3 PKDREJ POLR1C PPIH PPIL1 PSMD5 PSMF1 PTCD3 RAB6B RBM17 RLIM RNF138 ROPN1 RPA2 SCLY SCNM1 SFN SH3GLB2 SHISA2 SHTN1 SMARCB1 SRSF11 TAB1 TBC1D7 TCL1A TIFA TRAF1 TRAF2 TUBB UBE2D2 UBE2H UBE2I UBE2T UBE2Z USP2 VTN YJU2 ZNF148 ZNF410 ZNF581	8 interacting genes: BMPR2 EFNB2 LNX1 LNX2 RPS6KA1 SLC5A8 UBE2D2 VANGL2
Entrez ID		222484	23024
HPRD ID		10042	15115
Ensembl ID		ENSG00000139517	ENSG00000121440
Uniprot IDs		Q8N448	B7Z2I8 B7Z5Q3 B7Z5X9 B7ZAG0 E7ENB6 Q9UPQ7
PDB IDs		2VWR 5DIN 5E11 5E1Y 5E21 5E22 7QCT	1UHP 1WH1
Enriched GO Terms of Interacting Partners?		Nucleoplasm Phosphotyrosine Residue Binding Post-translational Protein Modification Nucleus Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Cytosol Ubiquitin-protein Transferase Activity Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Nuclear Speck Protein Ubiquitination Identical Protein Binding Response To Nitric Oxide Transferase Activity Cytoplasm	Epithelial Cell Proliferation Tube Morphogenesis Blood Vessel Morphogenesis Apical Plasma Membrane Animal Organ Morphogenesis Proteoglycan Metabolic Process System Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Activin Receptor Activity, Type II Cell Population Proliferation Proteoglycan Biosynthetic Process Epithelial Tube Morphogenesis Postsynaptic Density Membrane Positive Regulation Of Aorta Morphogenesis Ubiquitin-protein Transferase Activity Serotonergic Neuron Axon Guidance Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis PDZ Domain Binding Acetate Transport Monocarboxylate:sodium Symporter Activity Short-chain Fatty Acid Transmembrane Transport Organic Acid:sodium Symporter Activity Nitrate Transmembrane Transport Propanoate Transmembrane Transport Short-chain Fatty Acid Transport Propionate Transmembrane Transporter Activity Short-chain Fatty Acid Transmembrane Transporter Activity Nicotinate Transport Iodide Channel Activity Regulation Of Lung Blood Pressure Pulmonary Valve Development Tricuspid Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Aorta Morphogenesis Nervous System Development Apical Cytoplasm Establishment Of Body Hair Planar Orientation Anterior/posterior Pattern Specification Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Chondrocyte Proliferation
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