POLDIP2 and MAD2L2

Number of citations of the paper that reports this interaction (PubMedID 20554254)
0

Data Source:
BioGRID (two hybrid)

		POLDIP2	MAD2L2
Description		DNA polymerase delta interacting protein 2	mitotic arrest deficient 2 like 2
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Cell-cell Junction Midbody Mitochondrial Nucleoid Mitotic Spindle	Chromatin Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Spindle Cytoskeleton Zeta DNA Polymerase Complex Site Of Double-strand Break
	Molecular Function	DNA Binding Protein Binding	Transcription Corepressor Activity Protein Binding JUN Kinase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	DNA Repair DNA Damage Response Mitochondrion Organization Negative Regulation Of Macroautophagy Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Focal Adhesion Assembly Error-free Translesion Synthesis Mitotic Spindle Assembly Positive Regulation Of Mitotic Cytokinesis Vascular Associated Smooth Muscle Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair Double-strand Break Repair DNA Damage Response Actin Filament Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Positive Regulation Of DNA-templated Transcription Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
Drugs
Diseases
GWAS		Osteoprotegerin levels ( 25080503)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		19 interacting genes: AGTRAP ALAS1 APP ASCC2 CPE DNAAF6 DSCAM FBXO7 HDAC6 MAD2L2 MTUS2 PCNA PDPK1 POLD2 POLN PTEN REV1 SELENBP1 TAB1	47 interacting genes: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 CIMIP1 DEPDC5 ELK1 FAM217B FTO FZR1 GSC2 IKZF1 IKZF3 INCA1 KCTD9 KRT34 MAD2L1 MAD2L1BP MBD3L1 MYBPC2 PLAGL2 POLDIP2 PPM1B PRCC PRR5L PRRC2A RAB11FIP4 RBBP6 REL REV1 REV3L SFI1 SHLD1 TCF4 THAP6 TRIM27 TRIM54 TRIM7 YPEL3 YY1AP1 ZBED1 ZMYND12 ZNF511 ZNF558 ZNF655
Entrez ID		26073	10459
HPRD ID		17874	07246
Ensembl ID		ENSG00000004142	ENSG00000116670
Uniprot IDs		B4DEM9 Q9Y2S7	Q9UI95
PDB IDs		6Z9C 6ZLX	3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6K07 6K08 6KEA 6KTO 6M7A 6M7B 6NIF 6VE5 6WS0 6WS5 6WW9 6WWA 7L9P
Enriched GO Terms of Interacting Partners?		Translesion Synthesis Postreplication Repair DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Error-prone Translesion Synthesis DNA Replication Zeta DNA Polymerase Complex Neuron Projection Organization DNA Repair Response To Stress Regulation Of Growth DNA Strand Elongation Involved In DNA Replication DNA Metabolic Process Regulation Of Axon Extension Involved In Axon Guidance Collateral Sprouting Neuron Projection Morphogenesis DNA Strand Elongation DNA Damage Response Cellular Response To Stress Dendritic Spine Morphogenesis Ubiquitin Binding Cell Projection Morphogenesis DNA-directed DNA Polymerase Activity Positive Regulation Of Mitophagy Regulation Of Developmental Growth Positive Regulation Of Autophagy Of Mitochondrion Macromolecule Metabolic Process Central Nervous System Development Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Regulation Of Axonogenesis Regulation Of Peptidyl-serine Phosphorylation Dendritic Spine Organization Macromolecule Biosynthetic Process Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Cell Projection Organization Enzyme Binding Regulation Of Response To Calcium Ion Regulation Of Locomotion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Growth PCNA Complex Replisome Response To Dexamethasone 3-phosphoinositide-dependent Protein Kinase Activity Negative Regulation Of Synaptic Vesicle Clustering	Mitotic Checkpoint Complex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Metal Ion Binding Translesion Synthesis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Protein Binding Positive Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle DNA Binding DNA Biosynthetic Process Postreplication Repair Error-free Translesion Synthesis Positive Regulation Of Synapse Maturation DNA Synthesis Involved In DNA Repair Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Negative Regulation Of Type I Interferon Production Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Regulation Of Mitotic Cell Cycle Ubiquitin Ligase Activator Activity Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle DNA-binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Zinc Ion Binding Regulation Of Mitotic Sister Chromatid Separation Regulation Of Nuclear Division Negative Regulation Of Interferon-beta Production Positive Regulation Of Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition SUMO Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Metabolic Process Sequence-specific DNA Binding
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