LCE4A and ADAMTSL4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		LCE4A	ADAMTSL4
Gene Name		late cornified envelope 4A	ADAMTS-like 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Cellular_component Interstitial Matrix Endoplasmic Reticulum Lumen
	Molecular Function		Protease Binding Metalloendopeptidase Activity Protein Binding
	Biological Process	Keratinization	Protein O-linked Glycosylation Proteolysis Apoptotic Process Extracellular Matrix Organization Protein O-linked Fucosylation Positive Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation
Drugs
Diseases
GWAS			Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		23 interactors: ADAMTSL4 HOXA1 KRT31 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 MDFI MEOX2 OTX1 PLSCR1 RGS17 RGS20 RNF111 SMCP SPRY2	106 interactors: ADAMTSL5 AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 C19orf66 C6orf165 CATSPER1 CCDC26 CHCHD2 CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 DGCR6 DIP2A DLK2 DNPEP DSCR8 EIF4E2 FAH FAM124B FARS2 FBLN1 FBXW5 FHL3 FKBP1B FLNA FRS3 GATA2 GIP GLRX3 GMCL1P1 GNE GNMT GOLGA8EP HGF HOXA1 KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LCE4A LGALS14 LINC00671 LMO1 LMO2 LONRF1 LRRC29 MAPKBP1 MID2 MORN3 MVP NATD1 NMUR2 NTF4 NTN4 OLFM3 PID1 PIN1 PLSCR1 PRKAB2 PTGER3 RAB2B RCHY1 RHOJ SALL2 SLC23A1 SLC6A20 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIP6 TSSK3 TUBGCP4 ZNF417 ZNF587
Entrez ID		199834	54507
HPRD ID		17264	18237
Ensembl ID		ENSG00000187170	ENSG00000143382
Uniprot IDs		Q5TA78	F8WAD0 Q6UY14 Q9UFG7
PDB IDs
Enriched GO Terms of Interacting Partners?		Pattern Specification Process Positive Regulation Of Metabolic Process Embryonic Organ Morphogenesis Inner Ear Morphogenesis Ear Morphogenesis Positive Regulation Of Gene Expression Embryonic Organ Development Inner Ear Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Embryo Development Ear Development Embryonic Morphogenesis Anterior/posterior Pattern Specification Positive Regulation Of Transcription, DNA-templated Termination Of G-protein Coupled Receptor Signaling Pathway Optokinetic Behavior Abducens Nerve Formation Termination Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Catalytic Activity Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Facial Nucleus Development Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Organ Morphogenesis Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Rhombomere 4 Development Semicircular Canal Formation Regulation Of Signal Transduction Embryonic Skeletal System Morphogenesis Negative Regulation Of Signal Transduction Epithelium Development Rhombomere 3 Development Rhombomere 5 Development Metencephalon Development Negative Regulation Of Signaling Developmental Process Ubiquitin-dependent SMAD Protein Catabolic Process Somite Specification Phosphatidylserine Biosynthetic Process Sensory Perception Of Sound Regulation Of Signaling Embryonic Skeletal System Development Sensory Organ Development Diencephalon Morphogenesis Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Hindbrain Development Regulation Of G-protein Coupled Receptor Protein Signaling Pathway	Multicellular Organismal Development Keratinization Organ Development Developmental Process Keratinocyte Differentiation System Development Anatomical Structure Development Epidermis Development Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Epidermal Cell Differentiation Sensory Organ Development Response To Organic Substance Organic Anion Transport Positive Regulation Of Neuron Projection Regeneration Regulation Of Transcription From RNA Polymerase II Promoter Epithelium Development Cellular Response To Thyroid Hormone Stimulus MRNA Transcription From RNA Polymerase II Promoter Skin Development Positive Regulation Of Transcription, DNA-templated Transepithelial Transport Semicircular Canal Development Positive Regulation Of Gene Expression Regulation Of Branching Involved In Salivary Gland Morphogenesis MRNA Transcription Response To Thyroid Hormone Negative Regulation Of Hydrolase Activity Cell Differentiation Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?			abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Difference) ?			abl baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 rab21 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Intersection) ?