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LCE4A and SPRY2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
LCE4A
SPRY2
Gene Name
late cornified envelope 4A
sprouty homolog 2 (Drosophila)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Microtubule
Plasma Membrane
Microtubule Cytoskeleton
Ruffle Membrane
Molecular Function
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Biological Process
Keratinization
Establishment Of Mitotic Spindle Orientation
Epidermal Growth Factor Receptor Signaling Pathway
Sensory Perception Of Sound
Negative Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Ras GTPase Activity
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Cell Fate Commitment
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Lung Growth
Bud Elongation Involved In Lung Branching
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Signaling by EGFR
EGFR downregulation
Signaling by FGFR in disease
Signaling by EGFR in Cancer
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Spry regulation of FGF signaling
Signaling by FGFR
Negative regulation of FGFR signaling
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Fasting insulin-related traits (interaction with BMI) (
22581228
)
Orofacial clefts (
20023658
22863734
)
Type 2 diabetes (
20862305
)
Protein-Protein Interactions
23 interactors:
ADAMTSL4
HOXA1
KRT31
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP3-2
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP9-2
KRTAP9-4
MDFI
MEOX2
OTX1
PLSCR1
RGS17
RGS20
RNF111
SMCP
SPRY2
90 interactors:
ADAMTSL4
AQP1
ATRIP
C19orf66
CATSPER1
CBL
CBLB
CBLC
CHRD
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
EIF4E2
FAIM
FAM219A
FBN1
FRS3
GNE
GP9
GPRIN2
GRAP2
GRB2
HEXIM2
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1B
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
OTX1
PACSIN3
PLSCR1
PRKAB2
PTGER3
PTPN11
RAF1
RTFDC1
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SIAH2
SPRY1
STK16
TCAF1
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
Entrez ID
199834
10253
HPRD ID
17264
03916
Ensembl ID
ENSG00000187170
ENSG00000136158
Uniprot IDs
Q5TA78
O43597
PDB IDs
3BUM
3OB1
Enriched GO Terms of Interacting Partners
?
Pattern Specification Process
Positive Regulation Of Metabolic Process
Embryonic Organ Morphogenesis
Inner Ear Morphogenesis
Ear Morphogenesis
Positive Regulation Of Gene Expression
Embryonic Organ Development
Inner Ear Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Embryo Development
Ear Development
Embryonic Morphogenesis
Anterior/posterior Pattern Specification
Positive Regulation Of Transcription, DNA-templated
Termination Of G-protein Coupled Receptor Signaling Pathway
Optokinetic Behavior
Abducens Nerve Formation
Termination Of Signal Transduction
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Catalytic Activity
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Facial Nucleus Development
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Organ Morphogenesis
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Rhombomere 4 Development
Semicircular Canal Formation
Regulation Of Signal Transduction
Embryonic Skeletal System Morphogenesis
Negative Regulation Of Signal Transduction
Epithelium Development
Rhombomere 3 Development
Rhombomere 5 Development
Metencephalon Development
Negative Regulation Of Signaling
Developmental Process
Ubiquitin-dependent SMAD Protein Catabolic Process
Somite Specification
Phosphatidylserine Biosynthetic Process
Sensory Perception Of Sound
Regulation Of Signaling
Embryonic Skeletal System Development
Sensory Organ Development
Diencephalon Morphogenesis
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Hindbrain Development
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Negative Regulation Of Signaling
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Keratinization
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Signaling
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cellular Process
Keratinocyte Differentiation
Regulation Of Cell Activation
Negative Regulation Of Protein Metabolic Process
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Death
System Development
Death
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cell-cell Adhesion
Developmental Process
Multicellular Organismal Development
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Regulation Of T Cell Activation
Cellular Response To Organic Substance
Cell Differentiation
Anatomical Structure Development
Organ Development
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Protein Ubiquitination
Cellular Response To Growth Factor Stimulus
Regulation Of Protein Kinase Activity
Epidermal Cell Differentiation
Response To Growth Factor
Protein Modification By Small Protein Conjugation
Epithelium Development
Regulation Of Apoptotic Process
Regulation Of Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Kinase Activity
Regulation Of Immune System Process
Negative Regulation Of Cellular Metabolic Process
Tagcloud
?
beyond
carcinogenesis
carcinogenic
cdh1
chfr
continue
detailed
endometrial
explained
familial
generations
germ
grow
hmlh1
hypermethylation
imbalance
inherited
involve
micrornas
mir
mismatch
mmr
oncogenes
pten
rassf1a
rsk4
unopposed
worldwide
younger
Tagcloud (Difference)
?
beyond
carcinogenesis
carcinogenic
cdh1
chfr
continue
detailed
endometrial
explained
familial
generations
germ
grow
hmlh1
hypermethylation
imbalance
inherited
involve
micrornas
mir
mismatch
mmr
oncogenes
pten
rassf1a
rsk4
unopposed
worldwide
younger
Tagcloud (Intersection)
?